The role of bioidentical hormone replacement therapy in anti‐aging medicine: a review of the literature

Rosenthal, Amanda; Jacoby, Ted; Israilevich, Rachel; Moy, Ronald L.

doi:10.1111/ijd.14684

Cited by 7 publications

(5 citation statements)

References 61 publications

(95 reference statements)

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“…55, 42 cBHRT are not recommended by menopausal and endocrine societies because they are not properly regulated and have not been adequately tested for efficacy and safety. 42,55,56 Regarding menopausal skin treatment, although some small studies have found that cBHRT can increase skin hydration and reduce skin atrophy, 57 no large appropriately designed studies have yet been conducted.…”

Section: Estrogen Deficient Skinmentioning

confidence: 99%

Treatment of menopausal skin – A narrative review of existing treatments, controversies, and future perspectives

Merzel Šabović,

Kocjan,

Zalaudek

2024

Post Reprod Health

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Menopause is a state of estrogen deficiency that affects numerous estrogen-dependent tissues in the female body. Skin is one of the most affected organs. Many consider menopausal skin changes to be merely an aesthetic problem; however, they can significantly affect women’s quality of life. Currently, there are no approved effective treatments to prevent or alleviate skin changes associated with estrogen deficiency. Standard systemic hormone replacement therapy used to treat menopausal symptoms may be effective to some degree for skin treatment. In addition, compounded bioidentical hormone replacement therapy, selective estrogen receptor modulators, and phytoestrogens could also be used for skin treatment, although this is only hypothetical due to lack of data. Many questions therefore remain unanswered. On the other hand, topical, low-dose estrogen that would act only on the skin without systemic effects could be a possible option, as could be skin-only acting topical phytoestrogens. Such topical products without systemic effects could play a role in the treatment of menopausal skin. However, they are not currently approved because there is insufficient data on their safety and efficacy. A healthy lifestyle could have a positive effect on the menopausal skin. In this review, we provide an overview of the characteristics of menopausal skin, an outlook on the future treatment of menopausal skin with estrogens and other approaches, and the associated controversies and speculations. Overall, the importance of menopausal skin changes should not be neglected, and high-quality research is needed to gain new insights into the treatment of menopausal skin.

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Section: Estrogen Deficient Skinmentioning

confidence: 99%

Treatment of menopausal skin – A narrative review of existing treatments, controversies, and future perspectives

Merzel Šabović,

Kocjan,

Zalaudek

2024

Post Reprod Health

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“…The use of carefully documented bioidentical hormone therapy has been recently reviewed and presented to be effective and safe in postmenopausal women for dermal care, especially for anti-aging of the skin [ 77 ], however, there is a lack of uniformity in the various formulations that can be compounded, and attention should be exercised under careful guidance by a licensed health professional.…”

Section: Bioidentical Hormonesmentioning

confidence: 99%

Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin

Lephart

Naftolin²

2020

Dermatol Ther (Heidelb)

123

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Estrogen is a pivotal signaling molecule; its production is regulated by the expression of the aromatase (CYP19A1) gene from ovarian and peripheral tissue sites, and it is transmitted via estrogen receptors to influence many important biological functions. However, the narrative for this overview focuses on the decline of 17bestradiol levels from ovarian sites after menopause. This estrogen-deficient condition is associated with a dramatic reduction in skin health and wellness by negatively impacting dermal cellular and homeostatic mechanisms, as well as other important biological functions. The changes include loss of collagen, elastin, fibroblast function, vascularity, and increased matrix metalloproteinase(s) enzymatic activities, resulting in cellular and extracellular degradation that leads to dryness, wrinkles, atrophy, impaired wound healing/barrier function, decreased antioxidant capacity [i.e.,

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“…Moreover, skin surface lipids have been shown to be increased in patients supplemented with both estrogen and progesterone, while estrogen alone has a sebum-suppressive action, hinting at the sebum secretion promoting effects of progesterone ( Sator et al, 2001 ). Safety concerns have led to the application of HRT with bioidentical hormones at individualized doses tailored to each patient ( Rosenthal et al, 2019 ). Apart from bioidentical hormones, newly discovered phytoestrogens from fermented soybean extracts have been found to improve skin hydration and viscoelasticity in rats without systemic toxicities ( Rungseevijitprapa et al, 2021 ).…”

Section: Management Of Sebaceous Gland Agingmentioning

confidence: 99%

Aging in the sebaceous gland

Hou

Wei

Zouboulis

et al. 2022

Front. Cell Dev. Biol.

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Sebaceous glands (SGs) originate from hair follicular stem cells and secrete lipids to lubricate the skin. The coordinated effects of intrinsic and extrinsic aging factors generate degradation of SGs at a late age. Senescence of SGs could be a mirror of the late aging of both the human body and skin. The procedure of SG aging goes over an initial SG hyperplasia at light-exposed skin areas to end with SG atrophy, decreased sebum secretion, and altered sebum composition, which is related to skin dryness, lack of brightness, xerosis, roughness, desquamation, and pruritus. During differentiation and aging of SGs, many signaling pathways, such as Wnt/β-catenin, c-Myc, aryl hydrocarbon receptor (AhR), and p53 pathways, are involved. Random processes lead to random cell and DNA damage due to the production of free radicals during the lifespan and neuroendocrine system alterations. Extrinsic factors include sunlight exposure (photoaging), environmental pollution, and cigarette smoking, which can directly activate signaling pathways, such as Wnt/β-catenin, Notch, AhR, and p53 pathways, and are probably associated with the de-differentiation and hyperplasia of SGs, or indirectly activate the abovementioned signaling pathways by elevating the inflammation level. The production of ROS during intrinsic SG aging is less, the signaling pathways are activated slowly and mildly, and sebocytes are still differentiated, yet terminal differentiation is not completed. With extrinsic factors, relevant signaling pathways are activated rapidly and fiercely, thus inhibiting the differentiation of progenitor sebocytes and even inducing the differentiation of progenitor sebocytes into keratinocytes. The management of SG aging is also mentioned.

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The role of bioidentical hormone replacement therapy in anti‐aging medicine: a review of the literature

Cited by 7 publications

References 61 publications

Treatment of menopausal skin – A narrative review of existing treatments, controversies, and future perspectives

Treatment of menopausal skin – A narrative review of existing treatments, controversies, and future perspectives

Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin

Aging in the sebaceous gland

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