The role of biologic in foot and ankle trauma—a review of the literature

Zhao, Emily; Carney, Dwayne; Chambers, Monique C.; Ewalefo, Samuel O.; Hogan, MaCalus V.

doi:10.1007/s12178-018-9512-1

Cited by 8 publications

(5 citation statements)

References 60 publications

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“…Newer techniques have surfaced to further reduce the likelihood of delayed union or nonunion. Biologics such as BMAC, which is rich in mesenchymal cells, have shown good results with the management of nonunion [15][16][17] ; its use has been proposed in the setting of primary fixations where delayed union or nonunion is highly expected. 17 In our series, BMAC was applied to the fracture site in 2 patients at the time of primary surgery.…”

Section: Possible Concerns Future Of the Techniquementioning

confidence: 99%

“…Biologics such as BMAC, which is rich in mesenchymal cells, have shown good results with the management of nonunion [15][16][17] ; its use has been proposed in the setting of primary fixations where delayed union or nonunion is highly expected. 17 In our series, BMAC was applied to the fracture site in 2 patients at the time of primary surgery. As none of our patients had delayed or nonunion, it remains to be seen if BMAC was contributory to the success of fracture healing.…”

Section: Possible Concerns Future Of the Techniquementioning

confidence: 99%

See 1 more Smart Citation

The Use of Modified Ollier Approach and Structural Allograft for Fixation of Intra-articular Calcaneal Fractures

Tay

et al. 2021

Techniques in Foot &Amp; Ankle Surgery

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We describe the combination of an Ollier approach and use of a structural allograft, for displaced intra-articular calcaneal fractures, that minimizes soft issue complications known to plague such fractures. The soft tissue envelope around the fracture fragments is maintained, facilitating fracture reduction. The mini-open incision is positioned such that critical elements of the subtalar joint are adequately visualized throughout the reduction and fixation. We have used this procedure for all grades of Sanders intra-articular fractures with no significant shortterm complications thus far.Level of Evidence: Diagnostic Level V-Expert opinion. See Instructions for Authors for a complete description of levels of evidence.

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Section: Possible Concerns Future Of the Techniquementioning

confidence: 99%

Section: Possible Concerns Future Of the Techniquementioning

confidence: 99%

The Use of Modified Ollier Approach and Structural Allograft for Fixation of Intra-articular Calcaneal Fractures

Tay

et al. 2021

Techniques in Foot &Amp; Ankle Surgery

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“…Запропоновано декілька різновидів центрифуг, спеціально призначених для отримання ЗТП. Найбільш відома система -SmartPRP, американської компанії Harvest [21]. Отримання ЗТП в цьому випадку проводиться в два етапи.…”

Section: матеріали і методи дослідженняunclassified

Potential of Platelet-Rich Plasma Application for Patients With Pelvic Fractures in Combination With Other Segmental Bone Injuries in Polytrauma

Ивченко¹,

Trufanov²

2018

Act. Probl. of the Modern Med.

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The relevance of issues on polytrauma is determined by the constant increase in the number of road accidents, armed conflicts, terrorist acts, accompanied by the appearance of a large number of casualties with severe and extremely serious injuries. The purpose of study was to analyze the recent reports of relevant scientific literature and the results of our own experimental research to summarize data on current trends and relevance of studying the main factors determining the development of disorders in victims with pelvic fractures in combination with multiple and combined injuries, to enhance the prognostic criteria based on a comprehensive assessment of the clinical course of the disease and to improve the treatment by promoting reparative regeneration of bone tissue with platelet-rich plasma. Materials and methods.Through the period from 2017 to 2018, 35 patients with polytrauma were operated on at the Traumatology Department of the Municipal Clinical Emergency and Medical Care Hospital of Zaporizhzhia. Among the patients there were 19 men (54.29%) and 16 women (45.71%) aged from 23 to 77 years, mean age was 39 years. 22 persons (62.86%) had road traffic injuries, 10 (28.57%) had domestic injuries, 2 (5.71%) had occupational injuries and 1 patient (2.86%) had other type of traumas. ISS scale injury less than 17 scores was found in 20 patients (57.14%), injuries varying from 17 to 25 scores – in 12 (34.29%), from 26 to 40 scores – in 2 (5.71%), and injury assessed as more than 40 scores was found in 1 (2.86%) patient. All patients (100%) were verified to have pelvic bone injuries varying degrees. The injuries of pelvic girdle were more often combined with fractures of the proximal femur against the background of traumatic brain injury and were diagnosed in 17 cases (48.57%); the same type of trauma with concomitant fractures of extremities of other localization was detected in 12 cases (34.29%). There were diagnosed 11 cases (31.43%) of above mentioned traumas complicated with intraperitoneal injury, 9 cases (25.71%) complicated with vertebral fractures, and 6 cases (17.14%) complicated with chest trauma). Results and discussion. In the main group of patients receiving the treatment with platelet-rich plasma, radiologically visible union of the injured area developed in 10 people (83.33%) in 8 weeks. 1 patient (8.3%) developed the synosteosis in 12 weeks and 1 patient (8.3%) developed synosteosis in 16 weeks following the surgery. In the control group fusion was detected in 14 patients (60.87%) in 8 weeks and in 8 patients (34.78%) in 16 weeks. Conclusion. Reliably substantiated data were obtained according to the results of the analysis of contingency tables 4*4 and the calculation of χ2 for the efficiency coefficient according to the Wald formula (Chi-square 6.87 with p=0.009) that indicates better clinical effectiveness of the technique due to the additional introduction of platelet-rich plasma into the treatment mode in order to assess the dynamics of fracture consolidation processes in victims with multiple and concomitant injuries. The results obtained allow us to predict a favourable outcome in these patients.

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“…However, most of these methods lack evidence regarding their therapeutic efficacy. [6][7][8][9][10][11] Human placenta hydrolysate (hPH) such as Laennec is used to improve liver function in patients with chronic liver disease, 12) however, it is being used in a variety of ways in clinical practice, from wound healing to immunoregulation. According to recent studies, [13][14][15][16] Laennec is rich in bioactive substances, such as peptides and amino acids.…”

Section: Introductionmentioning

confidence: 99%

Effects of Human Placenta Extract (Laennec) on Ligament Healing in a Rodent Model

Shin¹,

Kim

Hada

et al. 2019

Biological & Pharmaceutical Bulletin

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Rich in bioactive substances such as amino acids and peptides, Laennec (human placenta hydrolysate) has been widely used to control various types of musculoskeletal pain. However, the effects of Laennec on tendon and ligament injuries are not clearly understood. In the present study, Laennec was tested to identify its in vivo effects on ligament injury in an animal model and its in vitro effects on tendon-derived fibrocytes. A total of 99 Sprague Dawley rats were divided into the negative control (normal) group (n 11) and the ligament injury group (n 88). The ligament injury group was subdivided into normal saline-treated group, Laennec-treated group, polydeoxyribonucleotide-treated group, and 20% dextrose-treated group. Ligaments were collected at 1 week and 4 weeks after treatment. Histologic and biomechanical properties were analyzed. In vitro effects of Laennec and polydeoxyribonucleotide on fibrocytes were also analyzed. Although all other treatment groups showed increased inflammatory cells, the Laennec-treated group maintained cell counts and activated macrophage levels that were similar to the normal group. Unlike the saline-treated group and dextrose-treated group, the Laennec-treated group had low levels of degenerative changes at 4 weeks after treatment. Supportively, in vitro results showed that the Laennec-treated group had increased collagen type I, scleraxis (Scx) and tenomodulin (Tnmd) expression (p < 0.05). Our study demonstrates that Laennec treatment enhances wound healing of damaged ligament by suppressing immune responses and reducing degenerative changes of damaged ligament. In addition, we found that Laennec induces the gene expression of type I collagen, Scx and Tnmd in fibrocytes, suggesting that Laennec may facilitate regeneration of damaged ligaments. Therefore, we expect that Laennec can be a useful drug to treat injured ligament.

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The role of biologic in foot and ankle trauma—a review of the literature

Cited by 8 publications

References 60 publications

The Use of Modified Ollier Approach and Structural Allograft for Fixation of Intra-articular Calcaneal Fractures

The Use of Modified Ollier Approach and Structural Allograft for Fixation of Intra-articular Calcaneal Fractures

Potential of Platelet-Rich Plasma Application for Patients With Pelvic Fractures in Combination With Other Segmental Bone Injuries in Polytrauma

Effects of Human Placenta Extract (Laennec) on Ligament Healing in a Rodent Model

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