The role of biomarkers (p16<sup>INK4a</sup> and Ki-67) in cervical cancer screening: An appraisal

Ahmed, S. A.; Obaseki, Darlington Ewaen; Mayun, AA; Mohammed, Aliyu; Rafindadi, Abdulmumini Hassan; Abdul, Muhammad

doi:10.4103/atp.atp_3_17

Cited by 9 publications

(10 citation statements)

References 2 publications

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“…p16 and Ki-67 double immunostaining is used to detect high-grade squamous intraepithelial lesions (SIL). [ 18 ] The p16 and Ki-67 staining intensities gradually increase as lesions progress from low-grade to high-grade SIL. [ 19 ] Diffuse staining for p16 is a marker of high-grade SIL and is not associated with HPV infections.…”

Section: Discussionmentioning

confidence: 99%

Condyloma acuminatum mimicking cervical cancer in a pregnant woman and treatment with cryotherapy: A case report

2022

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Rationale: Condyloma acuminata and anogenital warts are protruding papillomatous lesions caused by human papillomavirus. In pregnant women, condyloma acuminata over the cervical region may grow rapidly, mimicking cervical cancer. Patient concerns: A pregnant woman at 14 weeks of gestation with condyloma acuminatum mimicking cervical cancer was referred to our hospital for further management. Diagnosis: Condyloma acuminata. Interventions: Tumor biopsy was performed twice, and the pathology confirmed condyloma acuminatum. Immunohistochemistry revealed focal positivity for p16 and Ki-67. Cryotherapy was performed and regular follow-up was performed at 2-week intervals. A small residual condyloma acuminata was found and treated with cryotherapy. Outcome: During the follow-up period, no recurrence of condyloma acuminata was noted. She delivered a baby at 37 weeks of gestation via cesarean section, without complications. Lessons: Condyloma acuminata of the cervix may grow faster during pregnancy, mimicking cervical cancer. Multiple factors must be considered when treating condyloma acuminata during pregnancy. Cryotherapy is proposed as a 1st-line treatment in all trimesters because of its safety, convenience, and cost-effectiveness. Serial follow-up at 2-week intervals to observe post-cryotherapy conditions is recommended.

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Section: Discussionmentioning

confidence: 99%

Condyloma acuminatum mimicking cervical cancer in a pregnant woman and treatment with cryotherapy: A case report

2022

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“…Several immunohistochemical markers determine the proliferating nature of a lesion. Several studies state that P16 INK4a and Ki-67 may have a potential role in predicting the nature of CIN in progression to cervical cancer (Yu et al, 2016;Sharon et al,2016, Ahmed SA et al,2017, Hebbar et al, 2017. Cell cycle-dependent protein kinase inhibitor P16 INK4a is a protein that can negatively regulate the cell cycle.…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Marker of Proliferation Ki-67 and Cell Cycle Dependent Protein kinase Inhibitor P16INK4a in Cervical Biopsy to Determine Its Biological Behaviour

Śarmā

Das

Sarmah

2021

Asian Pac J Cancer Prev

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Objective: The aim of the study is to analyse the Immuno-histochemical expression of Ki-67 and P16 INK4a in CIN and cervical cancer cases and their utility to determine the accuracy of histological diagnosis and prediction of biological behavior of cervical lesion. Methodology: A retrospective cross-sectional study was carried in 110 numbers of cervical biopsy that included 25 CIN1, 21 CIN2, 12 CIN3, 26 SCC and 01 adenocarcinoma and 25 non neoplastic lesion. The tissue sections were stained with Ki-67 and P16 INK4a . Results: Ki-67 expression was seen in 55.5% (61/110) cases of cervical lesion., out of which 3.6% (4/110; cervicitis -2/110 and metaplasia-2/110) cases were non dysplaia, 51.8% (57/110) cases were dysplasia /CIN of varying grade including invasive cancer. P16 INK4a expression was noted 51.8% (57/110). There was an increasing trend of the intensity of Ki-67 and P16 INK4a from focal positivity in low grade lesion to diffuse intensity in higher grade lesion and is statistically significant. There was strong association between the two variables Ki-67 and P16 INK4a positive cases with their histologic grade. Conclusion: Though histopathology remains the ''gold standard'' for the diagnosis of CIN, both low and high-grade, biomarkers like Ki-67 and P16 INK4a have emerged as helpful adjuncts. Their combined use may assist in the histopathologic classification of preinvasive lesions and facilitate the distinction from nondysplasia.

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“…Histologically, squamous cell carcinoma is common, and classified as non-keratinizing or keratinizing variants 1 . Histomorphological diagnosis of cervical biopsy can result in under-or over-treatment and low diagnostic agreement rates 5 . Use of P16 as an adjuvant biomarker has improved diagnostic agreement 6 .…”

Section: Introductionmentioning

confidence: 99%

Expression of P16 biomarker in squamous cell carcinoma of uterine cervix and its association with clinico-pathological parameters: A cross-sectional study

2020

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Introduction: Cervical cancer is the most common cancer among females. P16 is the surrogate marker for cervical carcinoma. This study aimed to evaluate the association of P16 marker with clinic-pathological parameters in squamous cell carcinoma of uterine cervix. Methods: This was a cross-sectional study. Histological confirmed cases of squamous cell carcinoma (SCC) of cervix were considered. All cases were evaluated for IHC P16 expression as per lower anogenital squamous terminology (LAST) criteria and correlated with clinico-pathological parameters. The data was analyzed by SPSS software version 22. Results: Out of 75 cases, P16 biomarker expression was block positive, ambiguous and negative in 67 (89.3%), 5 (6.6%), and 3 (4%) cases, respectively. There was a significant association between P16 expression and age (p = 0.005). All cases between 30-59 years of age showed block positivity. There was no significant association between P16 expression and age at marriage (p = 0.951), age at menopause (p = 0.311), parity (p = 0.554), clinical symptoms/signs, stage of disease (p = 0.28), or histopathological grade (p = 0.877). Maximum expression was seen between 40-44 years. Moreover, all cases having 1 & 2 parity showed block positivity and all stage I cases showed block positivity. Conclusion: P16 biomarker was significantly expressed in cervical cancers of the relatively younger age group and those with early stage of disease.

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The role of biomarkers (p16^INK4a and Ki-67) in cervical cancer screening: An appraisal

Cited by 9 publications

References 2 publications

Condyloma acuminatum mimicking cervical cancer in a pregnant woman and treatment with cryotherapy: A case report

Condyloma acuminatum mimicking cervical cancer in a pregnant woman and treatment with cryotherapy: A case report

Predictive Value of Marker of Proliferation Ki-67 and Cell Cycle Dependent Protein kinase Inhibitor P16INK4a in Cervical Biopsy to Determine Its Biological Behaviour

Expression of P16 biomarker in squamous cell carcinoma of uterine cervix and its association with clinico-pathological parameters: A cross-sectional study

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The role of biomarkers (p16INK4a and Ki-67) in cervical cancer screening: An appraisal

Cited by 9 publications

References 2 publications

Condyloma acuminatum mimicking cervical cancer in a pregnant woman and treatment with cryotherapy: A case report

Condyloma acuminatum mimicking cervical cancer in a pregnant woman and treatment with cryotherapy: A case report

Predictive Value of Marker of Proliferation Ki-67 and Cell Cycle Dependent Protein kinase Inhibitor P16INK4a in Cervical Biopsy to Determine Its Biological Behaviour

Expression of P16 biomarker in squamous cell carcinoma of uterine cervix and its association with clinico-pathological parameters: A cross-sectional study

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The role of biomarkers (p16^INK4a and Ki-67) in cervical cancer screening: An appraisal