The Role of Biomaterials on Cancer Stem Cell Enrichment and Behavior

Ordikhani, Faride; Kim, Yonghyun; Zustiak, Silviya Petrova

doi:10.1007/s11837-015-1626-y

Cited by 9 publications

(6 citation statements)

References 60 publications

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“…There are few specialized instruments to artificially generate mechanical force, like the commerciallyavailable FlexCell FX-5000 compression system [99]. Scientists have invested in biomaterials and parameters like differential drug-sensitivity to enrich and perpetually culture CSCs in vitro [100].…”

Section: Tools For Novel Therapeutic Discoverymentioning

confidence: 99%

Mechanobiology of Cancer Stem Cells and Their Niche

Choudhury

Gupta

Chaturvedi

et al. 2019

Cancer Microenvironment

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Though the existence of cancer stem cells remained enigmatic initially, over the time their participation in tumorigenesis and tumor progression has become highly evident. Today, they are also appreciated as the causal element for tumor heterogeneity and drug-resistance. Cancer stem cells activate a set of molecular pathways some of which are triggered by the unique mechanical properties of the tumor tissue stroma. A relatively new field called mechanobiology has emerged, which aims to critically evaluate the mechanical properties associated with biological events like tissue morphogenesis, cell-cell or cell-matrix interactions, cellular migration and also the development and progression of cancer. Development of more realistic model systems and biophysical instrumentation for observation and manipulation of cell-dynamics in real-time has invoked a hope for some novel therapeutic modalities against cancer in the future. This review discusses the fundamental concepts of cancer stem cells from an intriguing viewpoint of mechanobiology and some important breakthroughs to date.

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Section: Tools For Novel Therapeutic Discoverymentioning

confidence: 99%

Mechanobiology of Cancer Stem Cells and Their Niche

Choudhury

Gupta

Chaturvedi

et al. 2019

Cancer Microenvironment

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“…Generally, cells conventionally require attachment to the surfaces of cell culture vessels in the presence of a culture medium. However, the attachment is not always necessary for the survival and proliferation of CSCs forming spheres [48,49]. Accordingly, inert biological materials lacking cell attachment could provide a 3D environment.…”

Section: Requirement Of Biomaterials In Csc Culturementioning

confidence: 99%

Cancer Stem Cell Microenvironment Models with Biomaterial Scaffolds In Vitro

et al. 2020

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Defined by its potential for self-renewal, differentiation and tumorigenicity, cancer stem cells (CSCs) are considered responsible for drug resistance and relapse. To understand the behavior of CSC, the effects of the microenvironment in each tissue are a matter of great concerns for scientists in cancer biology. However, there are many complicated obstacles in the mimicking the microenvironment of CSCs even with current advanced technology. In this context, novel biomaterials have widely been assessed as in vitro platforms for their ability to mimic cancer microenvironment. These efforts should be successful to identify and characterize various CSCs specific in each type of cancer. Therefore, extracellular matrix scaffolds made of biomaterial will modulate the interactions and facilitate the investigation of CSC associated with biological phenomena simplifying the complexity of the microenvironment. In this review, we summarize latest advances in biomaterial scaffolds, which are exploited to mimic CSC microenvironment, and their chemical and biological requirements with discussion. The discussion includes the possible effects on both cells in tumors and microenvironment to propose what the critical factors are in controlling the CSC microenvironment focusing the future investigation. Our insights on their availability in drug screening will also follow the discussion.

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“…detin enamel, cementum, and pulp. Ordikhani, Yonghyun, & Zustiak [7] showed the dependency of bio-medical properties and growth of cancer stem cells. Also, they found that the characteristics of the cancer stem cells can be affected by the interfaces involved during the growth of biomaterials.…”

Section: Aplications Of Interfacial Science and Rheologymentioning

confidence: 99%

Study on Interfacial Science and Rheology

Rawate¹,

Goswami²

2019

IJRAT

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The study focuses on the interfacial science and the rheology of the fluids at the interface. The basics of interface and interfacial properties are discussed. The term rheology is explained and the measurement methods of rheology are elaborated to calculate the interfacial properties. The future application of this study in different fields is explained. Different types of literature are discussed in the field of chemical engineering and biology. The applications like Bio-Interface, Nano-medicine are studied by the literature.

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The Role of Biomaterials on Cancer Stem Cell Enrichment and Behavior

Cited by 9 publications

References 60 publications

Mechanobiology of Cancer Stem Cells and Their Niche

Mechanobiology of Cancer Stem Cells and Their Niche

Cancer Stem Cell Microenvironment Models with Biomaterial Scaffolds In Vitro

Study on Interfacial Science and Rheology

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