The role of bisphosphonates in success and survival of dental implants - effects in osseointegration

Tsikouris, Theodoros P.

doi:10.22540/jrpms-04-125

Cited by 1 publication

(1 citation statement)

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“…Consequently, researchers have turned their attention to promote methods of delivering these drugs locally to the concerned site. (11)(12)(13) Sodium alendronate gel was manufactured and tested to accelerate osseointegration around dental implants with the concept of positive influence of bone remodeling adjacent to the dental implant, avoiding the undesirable systemic side effects. (1,14) Bone density is the amount of bone tissue defined in a certain volume of bone.…”

Section: Introductionmentioning

confidence: 99%

Impact of Alendronate Gel on Bone Density in Immediately Loaded Dental Implants: A Clinical Study

Yousef

Ateia

2021

Egyptian Dental Journal

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Purpose: Scientific researches have focused attention on accelerating osseointegration around dental implants to increase their success rate. Accordingly, many materials and techniques have been developed to optimize bone remodeling especially in immediately loaded implants. This clinical study aimed to investigate the impact of topical application of alendronate gel 1% on bone density around immediately loaded dental implants.Materials and Methods: Twenty dental implants were inserted in 16 patients. Cases were divided randomly into two equal groups; Group I (study group): 10 implants were placed after injection of alendronate gel 1% in the drilling sites. Group II (control group): 10 implants were placed immediately after drilling; no material was applied to their osteotomy sites. All implants were loaded immediately within 24-72 hours. In each implant recipient sit, bone density was determined pre-operatively using cone-beam computerized tomography (CBCT), then re-evaluated after six months of implant placement and loading. Results:The mean bone density pre-operatively for Group I and Group II were 557.30±132.06 HU and 567.62±110.72 HU respectively. After six months, the corresponding values were 852.03±176.43 HU and 670.11±117.71 HU respectively, indicating a statistically significant difference in bone density (P= 0.014) between both groups. Conclusion:Topical application of sodium alendronate gel increases bone density around dental implants, which can increase success rate of immediately loaded implants.

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