The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in children

Pieruzzi, Federico; Antolini, Laura; Salerno, Francesco; Giussani, Marco; Brambilla, Paolo; Galbiati, Susanna; Mastriani, Silvana; Rebora, Paola; Stella, Andréa; Valsecchi, Maria Grazia; Genovesi, Simonetta

doi:10.1097/hjh.0000000000000552

Cited by 56 publications

(68 citation statements)

References 61 publications

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“…This decrease depends mainly on the peripheral vascular resistance and will represent the efficiency of the vasodilator mechanisms. 8,21,22 Corroborating the studies of Franz et al 12 we observed that changes in lifestyle are closely related to improvements in the cardiovascular system.…”

Section: Discussionsupporting

confidence: 64%

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Interdisciplinary Therapy and Decrease of Cardiovascular Overload in Obese Patients

Cerrone

Poli

Sanches

et al. 2017

International Journal of Cardiovascular Sciences

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Section: Discussionsupporting

confidence: 64%

“…8,21,22 It is important to note that decreases in BP, HR and DP even in small magnitudes, promote large reductions in the rate of cardiovascular complications and general mortality. 23 The scientific literature shows that the physical exercise, present in the interdisciplinary therapy, promotes a decrease of the BP values in a chronic way.…”

Section: Discussionmentioning

confidence: 99%

Interdisciplinary Therapy and Decrease of Cardiovascular Overload in Obese Patients

Cerrone

Poli

Sanches

et al. 2017

International Journal of Cardiovascular Sciences

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“…Matteucci et al reported that in children with chronic renal insufficiency, the risk of LVH was four-fold greater in boys than in girls [27] and Meisinger et al found that men with CKD had higher concentrations of urinary albumin and greater cardiovascular risk than women [33]. Concentric LVH is believed to result primarily from hypertension and increased afterload [34]. In the present study, men had significantly higher values of BP and FPG, so it was quite possible for them to have greater aortic stiffness and lower total arterial compliance.…”

Section: Discussionmentioning

confidence: 99%

Gender-specific association of decreased estimated glomerular filtration rate and left vertical geometry in the general population from rural Northeast China

Dai

Chen

et al. 2017

BMC Cardiovasc Disord

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BackgroundLeft ventricular hypertrophy (LVH) is common and associated with cardiovascular outcomes among patients with known chronic kidney disease (CKD). However, the link between decreased estimated glomerular filtration rate (eGFR) and left ventricular (LV) geometry remains poorly explored in general population. In this study, we examined the gender-specific association between eGFR and LVH in the general population from rural Northeast China.MethodsThis survey was conducted from July 2012 to August 2013. A total of 10907 participants (5,013 men and 5,894 women) from the rural Northeast China were randomly selected and examined. LV mass index (LVMI) was used to define LVH (LVMI > 46.7 g/m2.7 in women; > 49.2 g/m2.7 in men). LV geometry was defined as normal, or with concentric remodeling, eccentric or concentric hypertrophy, according to relative wall thickness (RWT) and LVMI. Mildly decreased eGFR was defined as eGFR ≥ 60 and < 90 ml/min/1.73 m2, and moderate-severely decreased eGFR was defined as eGFR < 60 ml/min/1.73 m2.ResultsAs eGFR decreased, LVH showed a gradual increase in the entire study population. Multivariate analysis revealed a gender-specific relationship between eGFR and LV geometry. Only in men, mildly decreased eGFR was associated with concentric remodeling [odds ratio (OR): =1.58; 95% CI: 1.14–2.20; P < 0.01] and concentric LVH OR = 1.63; 95% CI: 1.15–2.31; P < 0.01). And only in men, moderate-severely decreased eGFR was a risk factor for concentric LVH (OR = 4.56; 95% CI: 2.14–9.73; P < 0.001) after adjusting for confounding factors.ConclusionsThese findings suggested that decreased eGFR was a risk factor for LV geometry in men, and a gender-specific difference should be taken into account in clinical practice.

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“…These reports describe a positive relationship of obesity with cardiac mass that appears to be independent of BP. 8,9 …”

Section: Introductionmentioning

confidence: 99%

Fibroblast growth factor-23 is independently associated with cardiac mass in African-American adolescent males

Falkner

Keith

Gidding

et al. 2017

Journal of the American Society of Hypertension

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Left ventricular hypertrophy (LVH) has been documented in hypertensive adolescents and among some with prehypertension. Obesity also appears to be associated with cardiac mass, independent of blood pressure (BP). Fibroblast growth factor-23(FGF23) is a novel biomarker positively associated with LVH in adults with and without kidney disease. The aim of this study was to determine if there was a significant and independent association of FGF23 with cardiac mass in a Black American adolescent cohort including both normotensive and prehypertensive (PH) participants with and without obesity. Measurements of BP, body mass index (BMI), plasma c-terminal FGF23, and echocardiographic measures of left ventricular mass index (LVMI) were obtained in 236 adolescents, aged 13–18 years, stratified by BMI as normal, overweight, or obese. LVMI differed significantly between normal, overweight, and obese groups (30.42±6.75 vs 33.49 ±8.65 vs 37.26±6.99 gm/m2.7; P<0.01). FGF23 was significantly higher in both overweight (53.03 RU/ml) and obese (54.40 RU/ml) compared to the normal weight (32.83 RU/ml) group; both P<0.01). In multiple linear regression analysis, variables significantly related to LVMI in males were BMI (P<0.0001), and FGF23 (P=0.005), but not BP, hsCRP or insulin. The only significant variable associated with LVMI in females was BMI (P<0.0001). In males, the contribution of FGF23 to predicting LVMI was independent of and in addition to obesity. These results suggest that FGF23 is an integral part of a complex pathway, associated with higher cardiac mass in African Americans males with excess adiposity.

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The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in children

Cited by 56 publications

References 61 publications

Interdisciplinary Therapy and Decrease of Cardiovascular Overload in Obese Patients

Interdisciplinary Therapy and Decrease of Cardiovascular Overload in Obese Patients

Gender-specific association of decreased estimated glomerular filtration rate and left vertical geometry in the general population from rural Northeast China

Fibroblast growth factor-23 is independently associated with cardiac mass in African-American adolescent males

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