The role of blood S100B and lactate levels in minor head traumas in children and adults and correlation with brain computerized tomography

Sezer, Ahmet Ali; Akıncı, Emine; Öztürk, Miraç; Coşkun, Figen; Yılmaz, Gülşen; Karakaş, Alpaslan; Toksöz, Talip

doi:10.5505/tjtes.2012.76736

Cited by 5 publications

(4 citation statements)

References 16 publications

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Section: Discussionmentioning

confidence: 96%

“…This study shows that PCO2 and lactate After head trauma knowing the biomarkers affecting the prognosis in patients progressing TBI makes it easier to determine the treatment priority, to detect patients who may be at risk early, and to predict the clinical outcome [8]. In determining the prognosis in TBI; Studies have been conducted with some biomarkers such as glucose, S100B, lactate, and thiol [9][10][11].ABG analysis is an examination that provides an overview of the acid-base balance in patients with TBI and can show the oxygen demand and requirements in the brain [12].Studies on the prognostic effects of ABG analysis have mostly been done on cardiovascular and respiratory system diseases. Our aim in this study is to evaluate the changes in ABG parameters in pediatric age group patients with severe head trauma and to nd their effects to prognosis, if any.…”

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confidence: 96%

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The Relationship of Blood Gas Values With Prognosis in Pediatric Patients With Severe Head Trauma

Kayabas

Şahin

2021

Preprint

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Purpose:Severe head traumas in the childhood age group has an important place in terms of mortality and morbidity among all traumas. Our aim in this study is to consider the relationship between the severity of severe head trauma and arterial blood gas (ABG) parameter levels in children.Methods:In our study, patients with head trauma, intubation and Glascow Coma Score (GCS) ≤ 8 were retrospectively analyzed. Showing homogeneous distribution; Independent sample T test was used for pH, PCO2 and base extract (BE) parameters, and Mann Whitney U test was used for PO2 and lactate parameters not showing homogeneous distribution. ROC analysis was done.Results:Of the 48 patients included in the study, 17 died while lying in the intensive care unit. There was no statistical difference when looking at the relationship between age, gender, surgical methods and mortality of the patients (p> 0.05). The relationship of patients with acidosis, hypercapnia and hyperlactatemia in ABG with mortality was statistically significant (p˂0.05). No statistically significant difference was found between surviving and deceased in ABG of patients regarding BE and hypoxia (p= 0.075; 0.175). there was a statistically significant difference between the mean values of PCO2 and lactate which are among the quantitative values and those who survived and died (p <0.05).Conclusion: Acidosis, the presence hypercapnia and hyperlactatemia were found to be associated with mortality in children with severe head trauma in ABG analysis. This study shows that PCO2 and lactate levels in ABG can be a biomarker in determining the prognosis in pediatric patients with traumatic brain injury (TBI).

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 96%

The Relationship of Blood Gas Values With Prognosis in Pediatric Patients With Severe Head Trauma

Kayabas

Şahin

2021

Preprint

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“…[8] To determine the TBI level and prognosis after head trauma, studies with glucose, S100 calcium-binding protein B and thiol have shown that they can be biomarkers. [9][10][11] Arterial blood gas (ABG) is an examination that provides an overview of acid-base balance and can show the oxygen need and requirements of tissues. [12] Studies on the effects of parameters in ABG on prognosis have been mostly conducted on cardiovascular and respiratory system diseases.…”

Section: Introductionmentioning

confidence: 99%

How Important Are Arterial Blood Gas Parameters for Severe Head Trauma in Children?

Kayabaş

Şahin

2022

Journal of Contemporary Medicine

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Aim: Our aim in this study is to consider the relationship between arterial blood gas (ABG) parameters and prognosis in severe head trauma in children. Material and Method:Patients younger than 17 years of age with a Glasgow Coma Scale (GCS) of 8 and below with a history of head trauma were retrospectively analyzed. The relation of ABG parameters taken at the time of admission with mortality was examined. Independent sample T-test was used for pH, PCO2 and base extract (BE) parameters in ABG, and Mann Whitney U test was used for PO2 and lactate parameters.Results: 48 patients were included in the study. Gender, age, admission blood pressure arterial values, GCS and Abbreviated Injury Scale (AIS) scores, length of stay in intensive care, and the surgical application did not differ statistically between the patient groups who died and survived. Ph and PO2 values were lower, PCO2, lactate, and BE values were found to be higher in the deceased patient group compared to the living patient group. The presence of acidosis, hypercapnia, or hyperlactatemia according to ABG values in the patient group who died was statistically significantly higher. Conclusion:In our study, we found that the presence of acidosis, hypercapnia, and hyperlactatemia in patients according to ABG values increased mortality. We found that high PCO2 and lactate values are specific indicators of poor prognosis. We think that PCO2 and lactate measured in arterial blood may be biomarkers that can determine the prognosis.

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“…Olayın veya yaralanmanın gerçekleşme zamanı ile kan örneğinin alınması arasında geçen zaman S100b sonuçlarını etkileyebilmektedir. 4 Müller ve ark. araştırmalarında, iskemik olaydan 3 saat sonrası yapılan S100b ölçümlerinin güvenilmez olduğunu ve çalışma sonuçlarını etkilediğini göstermiştir.…”

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S100b Protein Levels in Children with Head Trauma: Letter to the Editor

Eyi¹,

Aksoy²,

Ardiç³

et al. 2014

Turkiye Klinikleri J Med Sci

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Sayın Editör, erginizin 2013-1. sayısındaki "Kafa Travmalı Çocuklarda S-100b Protein Düzeyi ile Prognoz Arasındaki İlişki" başlıklı Sayın Avcı ve ark. tarafından yazılan makaleyi ilgi ile okuduk.1 Deneyimlerini bizlerle paylaştıkları için teşekkür ederiz. Makalede araştırılan biyokimyasal parametre ile ilgili birkaç temel özellikten bahsederek çalışma kısıtlılık-larına katkıda bulunmak istiyoruz.Kafa travmaları, pediyatrik yaş grubunda önemli mortalite ve morbidite sebebi olan bir halk sağlığı problemidir.2 Hastaların yaşamsal ve nörolo-jik bulgularının erken dönemde tespiti ile stabilizasyonun erkenden sağ-lanması için, Glaskow koma skalası ile başlayan nörolojik muayene ve bilgisayarlı tomografi gibi görüntüleme yöntemlerinin yanında, birçok biyokimyasal belirteç de kullanılmaktadır. 3 S100b; santral sinir lezyonları, iskemi ve nekroz gibi durumlardan sonra kanda saptanabilen, böbreklerde metabolize edilerek idrarla atılan ve yarı ömrü ortalama 120 dakika olan bir proteindir. Olayın veya yaralanmanın gerçekleşme zamanı ile kan örneğinin alınması arasında geçen zaman S100b sonuçlarını etkileyebilmektedir. 4 Müller ve ark. araştırmalarında, iskemik olaydan 3 saat sonrası yapılan S100b ölçümlerinin güvenilmez olduğunu ve çalışma sonuçlarını etkilediğini göstermiştir. 5Yazarlar çalışmalarında, son 6 saat içinde kafa travması öyküsü bulunan hastaların araştırmaya dahil edildiğini bildirmişlerdir. S100b proteinin yarılanma ömrü ve kanda yüksek saptanabildiği zamanlar göz önüne alındı-ğında, 3-6 saatlik zaman diliminde başvuran kafa travmalı hastaların serum S100b protein düzeyleri, S100b proteininin yarı ömrünün kısa olması nedeni ile beklenenden düşük seviyelerde olacak ve çalışma istatistiklerini etkileyecektir. Son 3-6 saat aralığında acil servise başvuran kafa travmalı hastaların çalışmaya dahil edilmesindense, kafa travması ile başvuran ve başvuru süresi 3 saati aşmayan olguların irdelenmesinin çalışmanın objektivitesini arttıracağı düşünmekteyiz.Değerli sunumları için Avcı ve arkadaşlarını kutlar, saygılarımızı sunarız.

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The role of blood S100B and lactate levels in minor head traumas in children and adults and correlation with brain computerized tomography

Cited by 5 publications

References 16 publications

The Relationship of Blood Gas Values With Prognosis in Pediatric Patients With Severe Head Trauma

The Relationship of Blood Gas Values With Prognosis in Pediatric Patients With Severe Head Trauma

How Important Are Arterial Blood Gas Parameters for Severe Head Trauma in Children?

S100b Protein Levels in Children with Head Trauma: Letter to the Editor

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