The role of bone marrow on the mechanical properties of trabecular bone: a systematic review

Wang, Fangxing; Metzner, Florian; Osterhoff, Georg; Zheng, Leyu; Schleifenbaum, Stefan

doi:10.1186/s12938-022-01051-1

Cited by 6 publications

(1 citation statement)

References 64 publications

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“…Numerical simulations published by Dalstra and Huiskes [10] and Linstrom et al [11] have demonstrated that material parameters can be site-dependent due to specific load-bearing areas relating to Wolff's law [12]. Comparative studies [13,14] have shown that variability in material parameters can be pronounced and is strongly dependent on the location and type of harvesting for both bony and soft tissue structures [6,[15][16][17][18]. A previous study addressed the relevance of standardization of preparation and storage of biomechanical specimens under the aspect of reproducibility [19].…”

Section: Introductionmentioning

confidence: 99%

Approach to standardized material characterization of the human lumbopelvic system – Testing and evaluation

Gebhardt,

Kurz,

Grundmann

et al. 2024

Preprint

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The osseo-ligamentous lumbopelvic complex is a crucial component of the human musculoskeletal system and has been increasingly the focus of medical research and treatment planning. Numerical simulations can play a key role in better understanding the load-carrying behavior of this system, but material data in this arena remain rare. In addition, the literature lacks standardized and reproducible methods for determining biomechanical material parameters.To address these shortcomings, we obtained bone and soft tissue samples from three female and two male cadavers (average age: 77.3 years) for testing and evaluation. The elastic modulus of cortical bone averaged at 1750 MPa with a mean ultimate strength of 28.2 MPa. Whereas for trabecular bone the evaluation yields to 32.7 MPa and 1.26 MPa. Furthermore, the soft tissue specimens exhibited a mean elastic modulus of 148 MPa and an ultimate strength of 14.3 MPa for fascial tissue, in contrast to ligamentous tissue with 103 MPa and 10.7 MPa.Knowledge of these material parameters of the human pelvis, which differ from those of long bones, could, in combination with the revealed dependence on harvesting location and density, lead to more precise mechanical simulations. Such simulations might in turn promote the development of better suited implants.Together with a previous publication dealing with sample preparation, this work is intended to contribute to the standardization of mechanical testing of human tissue. Easy-to-conduct bending tests as well as direct tension and compression tests are recommended, and the proposed mechanical boundary conditions are explained and documented. These technical recommendations allow for better comparability and reproducibility in future biomechanical studies. This protocol, developed for the human pelvis, could easily be transferred to other anatomical regions.

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Section: Introductionmentioning

confidence: 99%

Approach to standardized material characterization of the human lumbopelvic system – Testing and evaluation

Gebhardt,

Kurz,

Grundmann

et al. 2024

Preprint

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Bone Organoids: Recent Advances and Future Challenges

Zhao,

Saiding,

et al. 2023

Adv Healthcare Materials

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Bone defects stemming from tumorous growths, traumatic events, and diverse conditions present a profound conundrum in clinical practice and research. While bone has the inherent ability to regenerate, substantial bone anomalies require bone regeneration techniques. Bone organoids represent a new concept in this field, involving the 3D self‐assembly of bone‐associated stem cells guided in vitro with or without extracellular matrix material, resulting in a tissue that mimics the structural, functional, and genetic properties of native bone tissue. Within the scientific panorama, bone organoids ascend to an esteemed status, securing significant experimental endorsement. Through a synthesis of current literature and pioneering studies, this review offers a comprehensive survey of the bone organoid paradigm, delves into the quintessential architecture and ontogeny of bone, and highlights the latest progress in bone organoid fabrication. Further, existing challenges and prospective directions for future research are identified, advocating for interdisciplinary collaboration to fully harness the potential of this burgeoning domain. Conclusively, as bone organoid technology continues to mature, its implications for both clinical and research landscapes are poised to be profound.

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