The Role of Botulinum Toxin in Decompensated Strabismus

Abstract

Our results suggest almost half of those patients requiring treatment for decompensated squint benefit from botulinum toxin, without requiring surgical intervention. This approach is less invasive and allows potential for recovery of binocular function.

Botulinum Toxin Injection for the Treatment of Strabismus

“…4,7,23,24 In comparison, successful alignment rates were lower in adults with single rectus muscle injections. 15,25 Therefore, it is reasonable to conclude that bilateral injections of BTXA help to achieve the desired outcome. Both esotropic and exotropic patients are represented in the case series.…”

“…Each article was reviewed for disclosure of potential conflicts of interest of any of the authors because of a relationship with a commercial entity involved in the production or sale of the study drug. Only 4 of the articles provided disclosure statements (Bansal et al, 15 Tejedor and Rodriguez, 5 Tejedor and Rodriguez, 7 and Tejedor and Gutierrez-Carmona 16 ); in each of these studies, the authors had no potential conflicts to disclose. In the other 10 articles, no disclosure statement was provided, so assessment could not be made of a potential conflict.…”

“…Sener and Sanac 25 treated 70 patients, with a mean age of 26.1 years and with esotropia or exotropia, by injecting a single medial or lateral rectus muscle at 1 to 3 episodes and found successful motor outcome in only Ophthalmology Volume -, Number -, Month 2021 22% or 32% of patients at a mean follow-up of 24 or 36 months, respectively. Similarly, Bansal et al 15 treated 92 patients, with a mean age of 36 years who had a decompensated microtropia or phoria, with a single medial or lateral rectus injection at a single episode (86 patients) or at 2 episodes (6 patients) and found that only 44.5% had achieved successful alignment.…”

Heterophoria and Anomalies of Convergence and Accommodation

“…Some patients require repeat injection for the improvement to be maintained (Rowe et al 2010), but Bansal et al (2008) found 29% were asymptomatic following botulinum toxin injection. Some patients require repeat injection for the improvement to be maintained (Rowe et al 2010), but Bansal et al (2008) found 29% were asymptomatic following botulinum toxin injection.…”