The Role of Brain-Derived Neurotrophic Factor (BDNF) in Diagnosis and Treatment of Epilepsy, Depression, Schizophrenia, Anorexia Nervosa and Alzheimer’s Disease as Highly Drug-Resistant Diseases: A Narrative Review

Gliwińska, Aleksandra; Czubilińska-Łada, Justyna; Więckiewicz, Gniewko; Świętochowska, Elżbieta; Badeński, Andrzej; Dworak, Marta; Szczepańska, Maria

doi:10.3390/brainsci13020163

Cited by 30 publications

(12 citation statements)

References 120 publications

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“…However, unlike other transporter ligands, ibogaine inhibits these transporters non-competitively. It appears to bind to the extracellular surface of a conformation of the transporter that faces the cytoplasm[ 95 ] (Figure 2 ).…”

Section: Tcm Herbal Antidepressants: the Molecular Mechanism Of Their...mentioning

confidence: 99%

Exploring the transformative impact of traditional Chinese medicine on depression: Insights from animal models

Yang,

Chen,

Xie

2024

World J Psychiatry

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Depression, a prevalent and complex mental health condition, presents a significant global health burden. Depression is one of the most frequent mental disorders; deaths from it account for 14.3% of people worldwide. In recent years, the integration of complementary and alternative medicine, including traditional Chinese medicine (TCM), has gained attention as a potential avenue for addressing depression. This comprehensive review critically assesses the efficacy of TCM interventions in alleviating depressive symptoms. An in-depth look at different research studies, clinical trials, and meta-analyses is used in this review to look into how TCM practices like herbal formulations, acupuncture, and mind-body practices work. The review looks at the quality of the evidence, the rigor of the methods, and any possible flaws in the current studies. This gives us an idea of where TCM stands right now in terms of treating depression. This comprehensive review aims to assess the efficacy of TCM interventions in alleviating depressive symptoms. In order to learn more about their possible healing effects, the study also looks into how different types of TCM work, such as herbal formulas, acupuncture, and mind-body practices.

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Section: Tcm Herbal Antidepressants: the Molecular Mechanism Of Their...mentioning

confidence: 99%

Exploring the transformative impact of traditional Chinese medicine on depression: Insights from animal models

Yang,

Chen,

Xie

2024

World J Psychiatry

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“…In the past two decades, numerous studies show a link between neurotrophic factors and depression and mood disorders [ 101 ]. Ketamine’s mechanism of action in the rapid relief of depressive symptoms is involved in the activity of several neurotrophic factors [ 29 ].…”

Section: Reviewmentioning

confidence: 99%

“…BDNF plays a major role. Since its purification in 1982 [ 102 ], BDNF has been the focus of numerous studies investigating its role in physiologic neuroplasticity and its potential as a pharmacologic target to treat CNS disorders [ 101 ]. BDNF is the most highly expressed member of the neurotrophin family of growth factors.…”

Section: Reviewmentioning

confidence: 99%

Ketamine and the Disinhibition Hypothesis: Neurotrophic Factor-Mediated Treatment of Depression

Borsellino,

Krider,

Chea

et al. 2023

Pharmaceuticals

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Ketamine is a promising alternative to traditional pharmacotherapies for major depressive disorder, treatment-resistant depression, and other psychiatric conditions that heavily contribute to the global disease burden. In contrast to the current standard of care medications for these disorders, ketamine offers rapid onset, enduring clinical efficacy, and unique therapeutic potential for use in acute, psychiatric emergencies. This narrative presents an alternative framework for understanding depression, as mounting evidence supports a neuronal atrophy and synaptic disconnection theory, rather than the prevailing monoamine depletion hypothesis. In this context, we describe ketamine, its enantiomers, and various metabolites in a range of mechanistic actions through multiple converging pathways, including N-methyl-D-aspartate receptor (NMDAR) inhibition and the enhancement of glutamatergic signaling. We describe the disinhibition hypothesis, which posits that ketamine’s pharmacological action ultimately results in excitatory cortical disinhibition, causing the release of neurotrophic factors, the most important of which is brain-derived neurotrophic factor (BDNF). BDNF-mediated signaling along with vascular endothelial growth factor (VEGF) and insulin-like growth factor 1 (IGF-1) subsequently give rise to the repair of neuro-structural abnormalities in patients with depressive disorders. Ketamine’s efficacious amelioration of treatment-resistant depression is revolutionizing psychiatric treatment and opening up fresh vistas for understanding the underlying causes of mental illness.

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“…In contrast, m-BDNF has a high affinity for the tropomyosin kinase B (TrkB) receptor, promotes neuronal differentiation, and enhances neurite outgrowth, dendritic cell maturation, neuronal survival, synaptogenesis, synaptic plasticity, and connectivity [ 3 , 12 , 17 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar Disorder

Shkundin,

Halaris

2023

JPM

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Brain-Derived Neurotrophic Factor (BDNF) is crucial for various aspects of neuronal development and function, including synaptic plasticity, neurotransmitter release, and supporting neuronal differentiation, growth, and survival. It is involved in the formation and preservation of dopaminergic, serotonergic, GABAergic, and cholinergic neurons, facilitating efficient stimulus transmission within the synaptic system and contributing to learning, memory, and overall cognition. Furthermore, BDNF demonstrates involvement in neuroinflammation and showcases neuroprotective effects. In contrast, BDNF antisense RNA (BDNF-AS) is linked to the regulation and control of BDNF, facilitating its suppression and contributing to neurotoxicity, apoptosis, and decreased cell viability. This review article aims to comprehensively overview the significance of single nucleotide polymorphisms (SNPs) in BDNF/BDNF-AS genes within psychiatric conditions, with a specific focus on their associations with depression, schizophrenia, and bipolar disorder. The independent influence of each BDNF/BDNF-AS gene variation, as well as the interplay between SNPs and their linkage disequilibrium, environmental factors, including early-life experiences, and interactions with other genes, lead to alterations in brain architecture and function, shaping vulnerability to mental health disorders. The potential translational applications of BDNF/BDNF-AS polymorphism knowledge can revolutionize personalized medicine, predict disease susceptibility, treatment outcomes, and guide the selection of interventions tailored to individual patients.

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The Role of Brain-Derived Neurotrophic Factor (BDNF) in Diagnosis and Treatment of Epilepsy, Depression, Schizophrenia, Anorexia Nervosa and Alzheimer’s Disease as Highly Drug-Resistant Diseases: A Narrative Review

Cited by 30 publications

References 120 publications

Exploring the transformative impact of traditional Chinese medicine on depression: Insights from animal models

Exploring the transformative impact of traditional Chinese medicine on depression: Insights from animal models

Ketamine and the Disinhibition Hypothesis: Neurotrophic Factor-Mediated Treatment of Depression

Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar Disorder

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