The role of brain perivascular space burden in early-stage Parkinson’s disease

Shen, Ting; Yue, Yumei; Zhao, Suisheng; Xie, Juan‐Juan; Chen, Yanxing; Tian, Jun; Lv, Wen; Lo, Chun-Yi Zac; Hsu, Yi‐Cheng; Kober, Tobias; Zhang, Baorong; Lai, Hsin-Yi

doi:10.1038/s41531-021-00155-0

Cited by 47 publications

(46 citation statements)

References 68 publications

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“…Their results suggested an association between EPVS and SN degeneration in PD ( Li et al, 2020 ). Another study also showed that patients with PD had a higher PVS burden in BG and midbrain than NCs, and the PVS number in BG significantly correlated with disease severity and L -dopa equivalent dosage ( Shen et al, 2021 ). We speculated that a reduced glymphatic activity results in the accumulation of the misfolding proteins such as α-syn, which is implicated in the development of PVS dilation on MRI.…”

Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease

et al. 2021

Front. Aging Neurosci.

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Background: The aim of this study was to evaluate the glymphatic system activity in patients with Parkinson’s disease (PD) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) methods.Methods: In total, 71 patients with idiopathic PD and 36 age- and sex-matched normal controls (NCs) were involved. Patients with PD were divided into early (n = 35) and late (n = 36) subgroups, based on Hoehn and Yahr (HY) stages. We calculated the diffusivity along the perivascular spaces (ALPS), as well as projection fibers and association fibers separately, to acquire the ALPS index. Enlarged perivascular spaces (EPVS) and periventricular white matter hyperintensities were also rated. Differences in ALPS index between the PD group and NCs and between two PD subgroups and NCs were compared. In addition, a multivariate logistic regression analysis was conducted to investigate the association between ALPS index and clinical variables.Results: Patients with PD revealed lower ALPS index than NCs (p = 0.010). The late PD group exhibited significantly lower ALPS index than NCs (p = 0.006). However, there were no marked differences noticed in ALPS index between NCs and early PD group and between the two PD subgroups. In the early PD group, there was a significantly positive correlation between ALPS index and Mini-Mental State Examination (MMSE) score (β = 0.021, p = 0.029) and a negative correlation between ALPS index and EPVS score (β = −0.050, p = 0.034), after controlling for multiple variables. In the late PD group, ALPS index was inversely associated with age (β = −0.012, p = 0.004).Conclusion: Impairment of the glymphatic system is involved in PD. DTI-ALPS index could be a promising biomarker of glymphatic system in PD.

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Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease

et al. 2021

Front. Aging Neurosci.

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“…P ARKINSON'S disease (PD) is a chronic neurodegenerative disorder without pathologic treatment, characterized by motor symptoms (resting tremor, bradykinesia, rigidity and abnormal gait) and non-motor symptoms (depression, anxiety, cognitive decline, etc.) [1]- [3]. Patients usually need to seek treatment after 50 to 80% of the Substantia Nigra pars compacta (SNc) has been destroyed [4].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Brain Functional Network Based on EEG Signals for Early-Stage Parkinson’s Disease Detection

et al. 2022

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The early diagnosis of Parkinson's disease (PD) has always been a difficult problem to be solved clinically. At present, there is no clinical auxiliary diagnostic index for reference. We attempted to extract potential biomarkers for early PD from the currently used scalp EEG detection methods in clinical practice. We calculated the phase synchronization index to quantify the synchrony of EEG channels in various frequency bands (delta, theta, alpha and beta bands) of early PD. The results showed that the synchronization of early PD in the delta band was significantly lower than the healthy level, and the brain region reflecting the lower synchronization was located in the temporal lobe, the posterior temporal lobe, the parietal lobe (the posterior center) and the occipital lobe. Moreover, this lower synchronicity is consistent with weaker brain functional connections. Besides, by constructing functional brain network, the graph theoretic topological features of each frequency band of early PD are presented. We have found that early PD has characteristics of small world network in the delta and beta bands, and the efficiency of brain functional networks in early PD has significantly increased in the delta, alpha and beta bands. These results indicate that early PD has significant pathological changes from the perspective of brain function network analysis, and its characteristics can be described by multiple features, which may provide auxiliary guidance for the clinical diagnosis of early PD, and also provide theoretical support for the brain function changes of early PD.

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“…NPVSs are typically invisible due to small size in the range of 0.13-0.96 mm [ 39 ]. Seven Tesla (7T) MRI, with increased spatial resolution and signal-to-noise ratio, increases the detection of nPVSs [ 40 , 41 ]. The 7T sequences have been optimized to provide detailed assessment of distributions of nPVSs in the white matter and subcortical nuclei [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Normal-sized basal ganglia perivascular space related to motor phenotype in Parkinson freezers

Yue

Shen

et al. 2021

Aging

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Changes in basal ganglia (BG) perivascular spaces (PVSs) are related to motor and cognitive behaviors in Parkinson’s disease (PD). However, the correlation between the initial motor phenotype and PVSs distribution/burden in PD freezing of gait (FOG) remains unclear. In addition, the normal-sized PVSs (nPVSs) have not been well-studied. With high-resolution 7T-MRI, we studied nPVSs burden in BG, thalamus, midbrain and centrum semiovale. The numbers and volume of nPVSs were assessed in 10 healthy controls, 10 PD patients without FOG, 20 with FOG [10 tremor dominant (TD), 10 non-TD subtype]. Correlation analyses were further performed in relation to clinical parameters. In this proof of concept study, we found that the nPVS burden of bilateral and right BG were significantly higher in freezers. A negative correlation existed between the tremor score and BG-nPVSs count. A positive correlation existed between the levodopa equivalent daily dose and BG-nPVSs count. The nPVS burden correlated with the progression to FOG in PD, but the distribution and burden of nPVS differ in TD vs. non-TD subtypes. High resolution 7T-MRI is a sensitive and reliable tool to evaluate BG-nPVS, and may be a useful imaging marker for predicting gait impairment that may evolve into FOG in PD.

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The role of brain perivascular space burden in early-stage Parkinson’s disease

Cited by 47 publications

References 68 publications

Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease

Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease

Analysis of Brain Functional Network Based on EEG Signals for Early-Stage Parkinson’s Disease Detection

Normal-sized basal ganglia perivascular space related to motor phenotype in Parkinson freezers

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