The Role of Cadherin 12 (CDH12) in the Peritoneal Fluid among Patients with Endometriosis and Endometriosis-Related Infertility

Goławski, Ksawery; Soczewica, Robert; Kacperczyk‐Bartnik, Joanna; Mańka, Grzegorz; Kiecka, Mariusz; Lipa, Michał; Warzecha, Damian; Spaczyński, Robert; Piekarski, Piotr; Banaszewska, Beata; Jakimiuk, Artur; Issat, Tadeusz; Rokitaⴕ, Wojciech; Młodawski, Jakub; Szubert, Maria; Sieroszewski, Piotr; Raba, Grzegorz; Szczupak, Kamil; Kluz, Tomasz; Kluza, Marek; Wielgoś, Mirosław; Koc-Żórawska, Ewa; Żórawski, Marcin; Laudański, Piotr

doi:10.3390/ijerph191811586

Cited by 11 publications

(13 citation statements)

References 51 publications

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“…The cycle phase was calculated based on the last menstrual period and the average length of the menstrual cycle. Moreover, the phases of the menstrual cycle in women with and without endometriosis were determined by the histological dating of the eutopic endometrial samples collected simultaneously with pathological lesions [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis

Skarżyńska

Wróbel

Zborowska

et al. 2023

IJMS

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The aim of this study was to investigate the relationship between lactoferrin and iron and its binding proteins in women with endometriosis by simultaneously measuring these parameters in plasma and peritoneal fluid. Ninety women were evaluated, of whom 57 were confirmed as having endometriosis. Lactoferrin was measured by ELISA, transferrin, ferritin and iron on a Cobas 8000 analyser. Lactoferrin and transferrin in peritoneal fluid were lower compared to plasma, in contrast to ferritin and iron. In plasma, lactoferrin showeds associations with iron and transferrin in endometriosis and with ferritin in the group without endometriosis. Lactoferrin in peritoneal fluid correlated with lactoferrin, iron and transferrin of plasma in patients without endometriosis. The ratio of lactoferrin concentration in peritoneal fluid to plasma differentiated stage I versus IV of endometriosis and was negatively correlated with the iron ratio in patients without endometriosis. The ferritin ratio differentiated women with and without endometriosis. The very high ferritin ratios, especially in advanced stages of endometriosis, suggest the protective involvement of this protein in peritoneal fluid and the loss of this role by lactoferrin. The results demonstrate the validity of assessing iron metabolism in women with endometriosis, which may be useful as a marker of the disease and its progression.

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Section: Methodsmentioning

confidence: 99%

The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis

Skarżyńska

Wróbel

Zborowska

et al. 2023

IJMS

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“…A number of studies focused on the role of metalloproteinases, growth factors, cytokines, chemokines, miRNAs, and adhesion molecules. [47][48][49][50] Sundqvist et al investigated the expression of proteins involved in adhesion, attachment and invasion in samples collected from the eutopic and ectopic endometrium of 19 patients with endometriosis and 25 healthy controls: apolipoprotein E (ApoE), integrin β-2 (ITGB2), integrin β-7 (ITGB7), Laminin γ-1 (LAMC1), CD24 molecule (CD24), and junctional adhesion molecule-1 (JAM-1). The authors observed alterations in the expression of ApoE, JAM-1, LAMC1, CD24, and ITGB2 in different analyzed subgroups.…”

Section: Other Potential Indicators Of Dysregulation At the Molecular...mentioning

confidence: 99%

The Holy Grail of endometriosis biomarkers in the diagnostic process – How much would it be worth and what does it look like?

Kacperczyk-Bartnik,

Żeber-Lubecka,

Feduniw

et al. 2023

Journal of Endometriosis and Pelvic Pain Disorders

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Previously, the gold standard for the diagnosis of endometriosis involved the performance of laparoscopic surgery, which allows the visualization and histological examination of the endometrial tissue. According to the latest guidelines published by the European Society of Human Reproduction and Embryology (ESHRE) in 2022, surgery is recommended only in patients with diagnostic difficulties associated with the use of non-invasive methods or in case of inappropriate or unsuccessful empirical treatment. At the same time, it is not recommended to use the measurement of biomarkers in the endometrial tissue, blood, menstrual or uterine fluids to diagnose endometriosis as the ESHRE guideline development group indicated the need of larger, multi-center prospective studies on this matter. The aim of this narrative review is to present advances in knowledge on non-invasive endometriosis diagnostic opportunities with emphasis on proteomics, the use of endometrial aspiration biopsy, iron metabolism, vitamin D-binding protein, extracellular matrix signaling pathways, epithelial−mesenchymal transformation, and other molecular pathways, together with a critical analysis of studies cited in the recent ESHRE guidelines.

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“…Non-specific symptoms of endometriosis often result in a disregard of the problem by patients and clinicians, which in turn is associated with a diagnostic delay of 7–9 years [ 7 , 8 ]. Therefore, many researchers are looking for reliable and non-invasive biomarkers for the disease [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis

Warzecha

Załęcka

Mańka³

et al. 2022

IJMS

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Laparoscopy as a diagnostic tool for patients with suspected endometriosis is associated with several potentially life-threatening complications. Therefore, it is imperative to identify reliable, non-invasive biomarkers of the disease. The aim of this study was to analyse the concentrations of fibronectin and type IV collagen in peritoneal fluid and plasma to assess their role as potential biomarkers in the diagnosis of endometriosis. Fibronectin and collagen IV protein levels were assessed by surface plasmon resonance imaging (SPRi) biosensors with the usage of monoclonal antibodies. All patients enrolled in the study were referred for laparoscopy for the diagnosis of infertility or chronic pelvic pain (n = 84). The study group included patients with endometriosis confirmed during surgery (n = 49). The concentration of fibronectin in the plasma (329.3 ± 98.5 mg/L) and peritoneal fluid (26.8 ± 11.1 μg/L) in women with endometriosis was significantly higher than in the control group (251.2 ± 84.0 mg/L, 7.0 ± 5.9 μg/L). Fibronectin levels were independent of endometriosis stage (p = 0.874, p = 0.469). No significant differences were observed in collagen IV levels (p = 0.385, p = 0.465). The presence of elevated levels of fibronectin may indicate abnormalities in cell–ECM signalling during the course of endometriosis, and may be a potential biomarker for early detection.

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The Role of Cadherin 12 (CDH12) in the Peritoneal Fluid among Patients with Endometriosis and Endometriosis-Related Infertility

Cited by 11 publications

References 51 publications

The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis

The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis

The Holy Grail of endometriosis biomarkers in the diagnostic process – How much would it be worth and what does it look like?

Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis

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