The role of cadmium in obesity and diabetes

Tinkov, Alexey A.; Filippini, Tommaso; Ajsuvakova, Olga P.; Aaseth, Jan; Gluhcheva, Yordanka; Ivanova, Juliana; Bjørklund, Geir; Skalnaya, Margarita G.; Gatiatulina, Eugenia R.; Popova, Elizaveta V.; Немерешина, О. Н.; Vinceti, Marco; Skalny, Anatoly V.

doi:10.1016/j.scitotenv.2017.05.224

Cited by 223 publications

(98 citation statements)

References 139 publications

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“…It has a biological half-life in the kidneys between 10 and 30 years. The kidneys, liver, bones, respiratory, and reproductive systems are the main targets of cadmium intoxication [3][4][5]. The Itai-itai disease caused by cadmium pollution in 1960s in Japan is well known worldwide [6].…”

Section: Introductionmentioning

confidence: 99%

Concentration and Distribution of Cadmium in Coals of China

et al. 2018

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Abstract:Cadmium is considered an important toxicant of major environmental and occupational concern. It can contaminate water, soil, and the atmosphere through coal mining, beneficiation, combustion, etc. This paper is based on the published literature, especially those data reported during the recent 10 years, including 2999 individual samples from 116 coalfields or mines in 26 provinces in China. The arithmetic mean of cadmium in Chinese coals is 0.43 µg/g. Taking the coal reserves into consideration, the average value of cadmium in coal is estimated as 0.28 µg/g. Cadmium is mostly enriched in the Southern coal-distribution area during the Late Permian. Furthermore, cadmium is highly enriched in Hunan and Chongqing. The modes of occurrence of cadmium in Chinese coals are quite complex. Cadmium in Chinese coals has been found in sulfides, organic matter, silicate minerals, and other minerals. A marine environment may be the most significant factor that influences the cadmium accumulation in coal from the Southern coal-distribution area during the Late Permian. In addition, hydrothermal fluids, source rocks, and volcanic ash have also influenced the content of cadmium in some coalfields in China.

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Section: Introductionmentioning

confidence: 99%

Concentration and Distribution of Cadmium in Coals of China

et al. 2018

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“…Metals are ubiquitous environmental pollutants, with the primary sources of human exposure being the inhalation of dust or direct ingestion of contaminated food and water. Metal exposure has been related to obesity, diabetes, and metabolic syndrome [134][135][136][137].…”

Section: Metalsmentioning

confidence: 99%

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

et al. 2020

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Endocrine disruptors (EDCs) have been associated with the increased incidence of metabolic disorders. In this work, we conducted a systematic review of the literature in order to identify the current knowledge of the interactions between EDCs in food, the gut microbiota, and metabolic disorders in order to shed light on this complex triad. Exposure to EDCs induces a series of changes including microbial dysbiosis and the induction of xenobiotic pathways and associated genes, enzymes, and metabolites involved in EDC metabolism. The products and by-products released following the microbial metabolism of EDCs can be taken up by the host; therefore, changes in the composition of the microbiota and in the production of microbial metabolites could have a major impact on host metabolism and the development of diseases. The remediation of EDC-induced changes in the gut microbiota might represent an alternative course for the treatment and prevention of metabolic diseases.

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“…The U.S. Department of Health and Human Services and the International Agency for Research on Cancer have categorized cadmium as a human carcinogen, due to its potential to induce pulmonary tumors (ATSDR, 2011;Waalkes, 2003). The mechanisms that underlie Cd toxicity include induction of oxidative and endoplasmic reticulum stress, inflammation, genotoxicity, and interference with the biochemical functions of essential metals (e.g., zinc) (Klaassen et al, 2008;Tinkov et al, 2017).…”

Section: Cadmium As a Model Toxicantmentioning

confidence: 99%

Plasticity of Antioxidant Defense Pathways in Response to Aging and Cadmium in Glutathione-Deficient Mice

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Botta

et al. 2017

Free Radical Biology and Medicine

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The ability to maintain cellular homeostasis during aging is an important determinant of organismal health throughout the lifespan. Understanding key pathways that govern homeostatic responses to endogenous and exogenous stressors is an important goal in aging research. The Nrf2 (nuclear factor erythroid 2-related factor 2; NFE2L2)/Keap1 (Kelch-like erythroid cell-derived protein with CNC homology [ECH]associated protein 1) signaling pathway is one of the most important cellular defense and survival pathways, and has been shown to interact with a myriad of other signaling pathways, including those controlling xenobiotic metabolism, cellular growth, proliferation and nutrient sensing (Chartoumpekis and Kensler, 2013). Nrf2 can modulate the expression of genes involved in gluconeogenesis, fatty acid β-oxidation and lipogenesis, and can enhance (and be enhanced by) the effects of caloric restriction, a regimen that is known to promote longevity in many species (Fontana and Partridge,

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The role of cadmium in obesity and diabetes

Cited by 223 publications

References 139 publications

Concentration and Distribution of Cadmium in Coals of China

Concentration and Distribution of Cadmium in Coals of China

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

Plasticity of Antioxidant Defense Pathways in Response to Aging and Cadmium in Glutathione-Deficient Mice

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