The role of cancer-associated fibroblasts in the invasion and metastasis of colorectal cancer
Jinjin Yin,
Wenting Zhu,
Senling Feng
et al.
Abstract:Colorectal cancer (CRC) is the third most common cancer and has ranked the third leading cause in cancerassociated death globally. Metastasis is the leading cause of death in colorectal cancer patients. The role of tumor microenvironment (TME) in colorectal cancer metastasis has received increasing attention. As the most abundant cell type in the TME of solid tumors, cancer-associated fibroblasts (CAFs) have been demonstrated to have multiple functions in advancing tumor growth and metastasis. They can remodel… Show more
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