The role of cannabidiol in aging

Ni, Beibei; Schmithausen, Ricarda Maria; Dai, Meiling; Zhao, Junjiang; Yu, Liang; Yang, Xue; Han, Bing; Jiang, Man

doi:10.1016/j.biopha.2023.115074

Cited by 9 publications

(5 citation statements)

References 165 publications

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“…These findings are consistent with other studies that demonstrate that activation of SIRT1 alleviates oxidative damage and restores mitochondrial biogenesis [80,89,90]. The current findings point to the involvement of autophagy and mitochondrial biogenesis in the pathophysiology of DN triggered by Type 1 DM and provide a proof-of-concept rationale for the use of CBD and BC as pharmacological moderators of mitochondrial dysfunction through SIRT1 and AMPK [88]. The characteristics of STZ-induced DN in rats include lower nerve conduction and blood supply to the peripheral nerves, and increased pain hypersensitivity to hyperalgesia and allodynia.…”

Section: Discussionsupporting

confidence: 92%

“…These results also unambiguously imply that BC and CBD may protect against high glucose-induced neurotoxicity by limiting the cellular homeostasis and balancing oxidative stress and mitochondrial function [87]. The study by Hashish HM & Ni B et al [49] observed that BC and CBD treatment prevented HG-induced mitochondrial dysfunction and ROS production, respectively, by impacting, AMPK and SIRT1 induced mitochondrial biogenesis and Nrf2-mediated antioxidant signalling [40,88]. These observations demonstrate that mitochondrial biogenesis deficits play a critical role in the pathophysiology of DN, and activation of AMPK and SIRT1 function to restore this condition by promoting mitochondrial biogenesis.…”

Section: Discussionmentioning

confidence: 84%

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Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/SIRT3/Nrf2 Axis

Khan,

Kaur,

Rishi

et al. 2024

Preprint

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Background In this study we investigated in detail the role of cannabidiol (CBD), Beta-caryophyllene (BC), or their combinations in diabetic peripheral neuropathy (DN). The key factors that contribute to DN include mitochondrial dysfunction, inflammation, and oxidative stress. Methods Briefly, Streptozotocin (STZ) (55 mg/kg) was injected intraperitoneally to induce DN in Sprague Dawley rats and performed procedures including Randall Sellito Calipers, Von Frey Aesthesiometer, hot plate, and cold plate methods to determine mechanical and thermal hyperalgesia in vivo. The blood flow to the nerves was assessed by using the Laser Doppler device. Schwann cells were exposed to high glucose (HG) at a dose of 30 mM to induce hyperglycemia and DCFDA, JC1 & Mitosox staining were done to determine mitochondrial membrane potential, reactive oxygen species and mitochondrial superoxides in-vitro. The rats were administered i.p with BC (30mg/kg), CBD (15mg/kg), or combination while Schwann cells were treated with 3.65 µM CBD, 75 µM BC, or combination to assess their role in DN amelioration. Results Our results revealed that exposure to BC and CBD diminished HG-induced hyperglycemia in Schwann cells, in part, through reducing mitochondrial membrane potential, reactive oxygen species and mitochondrial superoxides. Further, BC and CBD combination treatment in-vivo could prevent the deterioration of mitochondrial quality control system by promoting autophagy and mitochondrial biogenesis while improving blood flow. CBD and BC treatments also reduced pain hypersensitivity to hyperalgesia and allodynia with increased antioxidant and anti-inflammatory action in diabetic rats. These in vivo effects were attributed to significant upregulation of AMPK, SIRT3, Nrf2, PINK1, PARKIN, LC3B, Beclin1 and TFAM functions while downregulation of NLRP3 inflammasome, NFκB, COX2 and p62 activity was noted as determined by western blotting. Conclusion the present studies demonstrated that STZ & HG induced oxidative and nitrosative stress play a crucial role in the pathogenesis of diabetic neuropathy. We find, for the first time, that CBD and BC combination ameliorate DN via modulating the mitochondrial quality control system.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 84%

Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/SIRT3/Nrf2 Axis

Khan,

Kaur,

Rishi

et al. 2024

Preprint

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“…CB1 and CB2 are widely distributed, with CB1 mainly distributed in the central nervous system, and CB2 in the immune system [ 17 , 18 ]. In addition, CB1 and CB2 expression in women under 50 years of age was relatively low, indicating that CB1 and CB2 expression is closely related to age and sex [ 19 , 20 ]. There are many important biological processes regulated by CB1 and CB2, including nitric oxide release, activation of the mitogen-activated protein kinase (MAPK) and COX-2 pathways and protein kinase A/C, and opening of the voltage-gated Ca 2+ and inward rectifier K + channels [ 21 , 22 ].…”

Section: Article Search Methodsmentioning

confidence: 99%

Research progress in the management of vascular disease with cannabidiol: a review

Guo,

Wei,

Deng

et al. 2024

J Cardiothorac Surg

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The morbidity and mortality rates associated with vascular disease (VD) have been gradually increasing. Currently, the most common treatment for VD is surgery, with the progress in drug therapy remaining slow. Cannabidiol (CBD) is a natural extract of Cannabis sativa L. with sedative, analgesic, and nonaddictive properties. CBD binds to 56 cardiovascular-related receptors and exerts extensive regulatory effects on the cardiovascular system, making it a potential pharmacological agent for the management of VD. However, most CBD studies have focused on neurological and cardiac diseases, and research on the management of VD with CBD is still rare. In this review, we summarize the currently available data on CBD in the management of VD, addressing four aspects: the major molecular targets of CBD in VD management, pharmacokinetic properties, therapeutic effects of CBD on common VDs, and side effects. The findings indicate that CBD has anti-anxiety, anti-oxidation, and anti-inflammatory properties and can inhibit abnormal proliferation and apoptosis of vascular smooth muscle and endothelial cells; these effects suggest CBD as a therapeutic agent for atherosclerosis, stress-induced hypertension, diabetes-related vasculopathy, ischemia-reperfusion injury, and vascular damage caused by smoking and alcohol abuse. This study provides a theoretical basis for further research on CBD in the management of VD.

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“…In this regard, CBD increases the activity of glutathione peroxidase (GPx) and reductase (GR) and, in human cardiomyocytes, was found to increase the mRNA level of superoxide dismutase (SOD) [57]. Another mechanism by which CBD exerts its antioxidative effects is by ameliorating dysfunctional mitochondria, a major endogenous source of ROS [58]. Liu et al showed that CBD could reduce caspase-1/interleukin-1β-mediated mitochondrial ROS generation in H 2 O 2 -treated human keratinocytes by binding to caspase-1 directly [59].…”

Section: Cannabinoids and Regulation Of The Redox Balancementioning

confidence: 99%

Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds

Rybarczyk,

Majchrzak-Celińska,

Krajka-Kuźniak

2023

Antioxidants

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The development and progression of cancer are associated with the dysregulation of multiple pathways involved in cell proliferation and survival, as well as dysfunction in redox balance, immune response, and inflammation. The master antioxidant pathway, known as the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, regulates the cellular defense against oxidative stress and inflammation, making it a promising cancer prevention and treatment target. Cannabinoids have demonstrated anti-tumor and anti-inflammatory properties, affecting signaling pathways, including Nrf2. Increased oxidative stress following exposure to anti-cancer therapy prompts cancer cells to activate antioxidant mechanisms. This indicates the dual effect of Nrf2 in cancer cells—influencing proliferation and apoptotic processes and protecting against the toxicity of anti-cancer therapy. Therefore, understanding the complex role of cannabinoids in modulating Nrf2 might shed light on its potential implementation as an anti-cancer support. In this review, we aim to highlight the impact of cannabinoids on Nrf2-related factors, with a focus on cancer prevention and treatment. Additionally, we have presented the results of several research studies that combined cannabidiol (CBD) with other compounds targeting Nrf2. Further studies should be directed toward exploring the anti-inflammatory effects of cannabinoids in the context of cancer prevention and therapy.

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The role of cannabidiol in aging

Cited by 9 publications

References 165 publications

Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/SIRT3/Nrf2 Axis

Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/SIRT3/Nrf2 Axis

Research progress in the management of vascular disease with cannabidiol: a review

Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds

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