The Role of Capsule Endoscopy in Crohn's Disease: A Review

Odeyinka, Oladipo; Alhashimi, Rasha; Thoota, Sankeerth; Ashok, Tejaswini; Palyam, Vishnu; Azam, Ahmad T; Sange, Ibrahim

doi:10.7759/cureus.27242

Cited by 4 publications

(4 citation statements)

References 67 publications

(97 reference statements)

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“…Based on the stated facts, CE proved to be a good complementary method for diagnosing SB Crohn's disease. More recently, Sange et al state that CE innovation reduced reading time, improved diagnostic accuracy, and enhanced image quality [73]. Figure 3 presents findings of active Chron's disease detected via intestinal CE.…”

Section: Crohn's Diseasementioning

confidence: 99%

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Endoscope Capsules: The Present Situation and Future Outlooks

Gounella,

Granado,

Hideo Ando Junior

et al. 2023

Bioengineering

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This paper presents new perspectives on photonic technologies for capsule endoscopy. It first presents a review of conventional endoscopy (upper endoscopy and colonoscopy), followed by capsule endoscopy (CE), as well as their techniques, advantages, and drawbacks. The technologies for CEs presented in this paper include integration with the existing endoscopic systems that are commercially available. Such technologies include narrow-band imaging (NBI), photodynamic therapy (PDT), confocal laser endomicroscopy (CLE), optical coherence tomography (OCT), and spectroscopy in order to improve the performance of the gastrointestinal (GI) tract examination. In the context of NBI, two optical filters were designed and fabricated for integration into endoscopic capsules, allowing for the visualization of light centered at the 415 nm and 540 nm wavelengths. These optical filters are based on the principle of Fabry-Perot and were made of thin films of titanium dioxide (TiO2) and silicon dioxide (SiO2). Moreover, strategies and solutions for the adaptation of ECs for PDT are also discussed.

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Section: Crohn's Diseasementioning

confidence: 99%

“…Bioengineering 2023, 10, x FOR PEER REVIEW 7 of 28 hanced image quality [73]. Figure 3 presents findings of active Chron's disease detected via intestinal CE.…”

Section: Celiac Diseasementioning

confidence: 99%

Endoscope Capsules: The Present Situation and Future Outlooks

Gounella,

Granado,

Hideo Ando Junior

et al. 2023

Bioengineering

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show abstract

Section: Crohn's Diseasementioning

confidence: 99%

Endoscope Capsules: Present Situation and Future Outlook

Gounella,

Granado,

Hideo Ando Junior

et al. 2023

Preprint

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This paper presents new perspectives of photonic technologies for capsule endoscopy. It is firstly presented a review about conventional endoscopy (upper endoscopy and colonoscopy), followed by capsule endoscopy (CE), as well as their techniques, advantages, and drawbacks. The technologies for CEs presented in this paper have the potential of integration on the existing endoscopic systems commercially available. Such technologies include narrow band imaging (NBI), photodynamic therapy (PDT), confocal laser endomicroscopy (CLE), Optical coherence tomography (OCT) and Spectroscopy in order to improve the performance of the gastrointestinal (GI) tract examination. In the context of NBI, two optical filters were designed and fabricated for integration into endoscopic capsules, allowing the visualization of light centered at the 415 nm and 540 nm. These optical filters are based on the principle of Fabry-Perot and were made of thin-films of titanium dioxide (TiO2) and silicon dioxide (SiO2). Moreover, strategies and aid solutions for the adaptation of ECs for PDT are also discussed.

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“…Capsule endoscopy (CE) is a minimally invasive procedure initially designed to assess the small bowel (SB), demonstrating a high diagnostic yield in detecting SB lesions. 1 , 2 …”

Section: Introductionmentioning

confidence: 99%

Deep learning and minimally invasive inflammatory activity assessment: a proof-of-concept study for development and score correlation of a panendoscopy convolutional network

Cardoso,

Mascarenhas,

Afonso

et al. 2024

Therap Adv Gastroenterol

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Background: Capsule endoscopy (CE) is a valuable tool for assessing inflammation in patients with Crohn’s disease (CD). The current standard for evaluating inflammation are validated scores (and clinical laboratory values) like Lewis score (LS), Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI), and ELIAKIM. Recent advances in artificial intelligence (AI) have made it possible to automatically select the most relevant frames in CE. Objectives: In this proof-of-concept study, our objective was to develop an automated scoring system using CE images to objectively grade inflammation. Design: Pan-enteric CE videos (PillCam Crohn’s) performed in CD patients between 09/2020 and 01/2023 were retrospectively reviewed and LS, CECDAI, and ELIAKIM scores were calculated. Methods: We developed a convolutional neural network-based automated score consisting of the percentage of positive frames selected by the algorithm (for small bowel and colon separately). We correlated clinical data and the validated scores with the artificial intelligence-generated score (AIS). Results: A total of 61 patients were included. The median LS was 225 (0–6006), CECDAI was 6 (0–33), ELIAKIM was 4 (0–38), and SB_AIS was 0.5659 (0–29.45). We found a strong correlation between SB_AIS and LS, CECDAI, and ELIAKIM scores (Spearman’s r = 0.751, r = 0.707, r = 0.655, p = 0.001). We found a strong correlation between LS and ELIAKIM ( r = 0.768, p = 0.001) and a very strong correlation between CECDAI and LS ( r = 0.854, p = 0.001) and CECDAI and ELIAKIM scores ( r = 0.827, p = 0.001). Conclusion: Our study showed that the AI-generated score had a strong correlation with validated scores indicating that it could serve as an objective and efficient method for evaluating inflammation in CD patients. As a preliminary study, our findings provide a promising basis for future refining of a CE score that may accurately correlate with prognostic factors and aid in the management and treatment of CD patients.

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The Role of Capsule Endoscopy in Crohn's Disease: A Review

Cited by 4 publications

References 67 publications

Endoscope Capsules: The Present Situation and Future Outlooks

Endoscope Capsules: The Present Situation and Future Outlooks

Endoscope Capsules: Present Situation and Future Outlook

Deep learning and minimally invasive inflammatory activity assessment: a proof-of-concept study for development and score correlation of a panendoscopy convolutional network

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