The role of carbetocin in the prevention and management of postpartum haemorrhage

Onwochei, Desire N.; Monks, David T.

doi:10.1016/j.ijoa.2017.06.001

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Most post-partum hemorrhage is due to an atonic uterus. Use of uterotonics such as misoprostol or oxytocin, and perhaps carbetocin, a log-acting and heat stable oxytocin substitute, given immediately after delivery can prevent many of the post-partum hemorrhages associated with an atonic uterus [ 41 ]. However, major reductions in mortality from hemorrhage usually occur with appropriate treatment of hemorrhage once it occurs.…”

Section: Introductionmentioning

confidence: 99%

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Improving pregnancy outcomes in low- and middle-income countries

2018

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This paper reviews the very large discrepancies in pregnancy outcomes between high, low and middle-income countries and then presents the medical causes of maternal mortality, stillbirth and neonatal mortality in low-and middle-income countries. Next, we explore the medical interventions that were associated with the very rapid and very large declines in maternal, fetal and neonatal mortality rates in the last eight decades in high-income countries. The medical interventions likely to achieve similar declines in pregnancy-related mortality in low-income countries are considered. Finally, the quality of providers and the data to be collected necessary to achieve these reductions are discussed. It is emphasized that single interventions are unlikely to achieve important reductions in pregnancy-related mortality. Instead, improving the overall quality of pregnancy-related care across the health-care system will be necessary. The conditions that cause maternal mortality also cause stillbirths and neonatal deaths. Focusing on all three mortalities together is likely to have a larger impact than focusing on one of the mortalities alone.

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Section: Introductionmentioning

confidence: 99%

“…Infection is the generally considered the second most common cause of maternal death [ 10 ]. The most important causes of infection-related maternal mortality are the bacterial infections of the uterus and related sepsis [ 41 ]. The reasons for the high risk of infection post-partum are not hard to understand.…”

Section: Introductionmentioning

confidence: 99%

Improving pregnancy outcomes in low- and middle-income countries

2018

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“…Carbetocin is a potent and selective oxytocin receptor agonist, which is brain permeant and shows a longer elimination half-life than oxytocin (Dvorská et al, 1992). This drug is currently marketed in different countries for the treatment of postpartum bleeding in humans (Chen et al, 2016;Engstrøm et al, 1998;Meshykhi et al, 2016;Onwochei and Monks, 2017;Van der Nelson et al, 2017). Carbetocin is a synthetic peptide that shows no oral bioavailability and therefore cannot be transferred from lactating dams to pups through the milk (Silcox et al, 1993).…”

Section: Introductionmentioning

confidence: 99%