The role of cardiac magnetic resonance imaging in the detection and monitoring of cardiotoxicity in patients with breast cancer after treatment: a comprehensive review

Jafari, Fatemeh; Safaei, Akbar; Hosseini, Leila; Asadian, Sanaz; Kamangar, Tara Molanaie; Zadehbagheri, Fatemeh; Rezaeian, Nahid

doi:10.1007/s10741-020-10028-y

Cited by 19 publications

(15 citation statements)

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“…18 Through the present study, to our knowledge, we are the first to evaluate the predictive value of the traditional and novel CMR parame- The myocardial strain analysis can confer the early detection of cardiac abnormalities even before a marked decrease in RV EF in different medical conditions with cardiac involvement. 22,23 Additionally, strain parameters have prognostic implications in patients suffering from PH. The feature-tracking method is an advanced CMR technique in the evaluation of heart deformation that obviates the need for acquiring specified sequences.…”

Section: Discussionmentioning

confidence: 99%

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The predictive role of cardiac magnetic resonance imaging in determining thalassemia patients with intermediately to highly probable pulmonary hypertension

et al. 2021

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Objectives:We sought to determine the cardiac magnetic resonance (CMR) indicators of intermediately to highly probable pulmonary hypertension (IHpPH) in patients with thalassemia referred for myocardial iron overload assessments to prevent further cardiac complications. Methods:The study population consisted of 152 patients with thalassemia (major or intermedia) (49.3% women, mean age = 33 ± 10.1 years) who underwent non-contrast CMR and echocardiographic examinations on the same day. Functional, T2*, and global strain parameters via a feature-tracking method were extracted from CMR. The probability of PH was defined based on the tricuspid regurgitation velocity and echocardiographic parameters. The catheterization-derived hemodynamic data of patients with moderate to high probable PH was registered.Results: Twenty-two (14.5%) patients suffered from IHpPH. The multivariate logistic regression analysis revealed that the right ventricular end-systolic volume index (RVESVI) was the strongest of all the CMR parameters for the prediction of IHpPH (OR:1.044, 95% CI: 1.021-1.067). The other powerful IHpPH predictor was age (OR: 1.066, 95% CI: 1.009-1.126). A cutoff point of greater than 47 ml for RVESVI (AUC: .801, 95% CI: .728-.861) was found to predict IHpPH with 73.91% sensitivity and 70.31% specificity. The single most robust CMR-derived strain parameter for IHpPH prediction was the right ventricular global longitudinal strain (OR: .887, 95% CI: .818-.961). A p value of less than 0.05 was considered significant. Conclusions:Both CMR functional and global strain parameters were strong predictors of IHpPH in our patients with thalassemia. K E Y W O R D Scardiac magnetic resonance (CMR), intermediately to highly probable pulmonary hypertension (IHpPH), pulmonary hypertension (PH), thalassemia INTRODUCTIONThalassemia, considered the most typical of all hereditary disorders, results in the diminished or absent synthesis of hemoglobin chains. 1Globally, there are approximately 270 million carriers of various hemoglobinopathies, of whom 30% are carriers of β-thalassemia. 2 Cardiac complications persist as the main cause of morbidity and the leading cause of mortality in these patients. [3][4][5][6] Heart injury due to myocardial iron overload (MIO) is not completely reversible. There are multiple causes of cardiac disease, especially in older thalassemia

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Section: Discussionmentioning

confidence: 99%

“…The myocardial strain analysis can confer the early detection of cardiac abnormalities even before a marked decrease in RV EF in different medical conditions with cardiac involvement 22,23 . Additionally, strain parameters have prognostic implications in patients suffering from PH.…”

Section: Discussionmentioning

confidence: 99%

The predictive role of cardiac magnetic resonance imaging in determining thalassemia patients with intermediately to highly probable pulmonary hypertension

et al. 2021

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“…Advanced feature-tracking cardiac magnetic resonance (FT-CMR) imaging has contributed to the diagnostic and prognostic evaluation of a diverse range of cardiac disorders in recent years. Different studies have concluded that LV myocardial strain, as measured via the FT-CMR technique, is a sensitive predictor of preclinical LV dysfunction [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Feature-tracking cardiac magnetic resonance method: a valuable marker of replacement fibrosis in hypertrophic cardiomyopathy

Rezaeian¹,

Hosseini²,

Omidi³

et al. 2022

Pol J Radiol

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Purpose: Left ventricular (LV) replacement fibrosis is a marker of adverse cardiac events in hypertrophic cardiomyopathy (HCM). We aimed to assess the efficacy of the feature-tracking cardiac magnetic resonance (FT-CMR) in the detection of LV replacement fibrosis. Material and methods:Fifty-one patients with HCM (51% female, mean age = 21 ± 5.2 years) and significant myocardial hypertrophy, who underwent CMR between February 2018 and December 2019 were enrolled. Functional and 3D FT-CMR parameters were measured. LV global longitudinal strain, global radial strain (GRS), and global circumferential strain (GCS) were recorded. The percentage of enhanced myocardial mass was calculated. Univariate and multivariate regression analyses were performed to determine the predictors of fibrosis. A p-value of less than 0.05 was considered significant. Results:The mean enhanced mass percentage was 15.2 ± 10.53%. Among LV volumetric parameters, end-systolic and end-diastolic volume indices predicted fibrosis (fitness [F] = 8.11 and p = 0.006 vs. F = 6.6 and p = 0.012, correspondingly). The univariate linear regression demonstrated that GCS and GRS predicted total enhanced mass (%) (F = 12.29 and p = 0.001 vs. F = 7.92 and p = 0.007, respectively). After the inclusion of all volumetric and deformation parameters, the multivariate analysis identified the model of a combination of LV end-diastolic volume index (LV EDVI) and LV GCS as a robust predictor of the fibrosis percentage (F = 8.86 and p = 0.005). Conclusions:Non-contrast CMR parameters including LV GCS and LV EDVI are valuable markers of replacement fibrosis in HCM patients with notable myocardial hypertrophy.

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“…FT-CMR method has diagnostic potential in many cardiac disorders such as the different types of cardiomyopathies. This technique is contrast-free and is valuable in patients with the limitation in the administration of the gadolinium-based agents [ 14 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Auxiliary Role of Cardiac Magnetic Resonance Feature-Tracking Parameters in the Differentiation between Cardiac Amyloidosis and Constrictive Pericarditis

Asadian

Farzin

Tabesh

et al. 2021

Cardiology Research and Practice

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Objectives. Cardiac amyloidosis (CA) and constrictive pericarditis (CP) are described as the differential diagnoses of restrictive hemodynamic alterations of the heart. We aimed to explain cardiac magnetic resonance (CMR) imaging findings (especially feature tracking (FT)) of CA and CP cases and compare them with healthy controls. Moreover, we evaluated the role of biventricular FT parameters in differentiating CA from CP. Methods. Thirty-eight patients who underwent CMR between February 2016 and January 2018 with the ultimate diagnosis of CA (19 patients) or CP (19 patients) were enrolled. We included biopsy-proven light-chain amyloidosis patients. The data of 28 healthy controls were utilized for comparison. The patients were followed up for 8–23 months to register mortality and their surveillance. All CMR morphological and functional data, including FT parameters, were recorded and analyzed. Results. Of only 13/19 (68.4%) CA patients who had the follow-up data, 11/13 (84.6%) died. One of The CP patients (5.3%) expired during the follow-up. Significant between-group differences were noted concerning the biventricular ejection fraction as well as global longitudinal, circumferential, and radial strain values ( P s < 0.001 ). The left ventricular (LV) global longitudinal strain (GLS) ≤10% was detected in 13/19 (68.4%) of the CA and 1/19 (5.3%) of CP cases ( P < 0.001 ). A significant difference between the mean value of the LVGLS and LV global circumferential strain (GCS) of the basal LV level compared to the mid and apical levels was observed ( P s < 0.001 ) in the CA patients. The differences between the mean LVGLS and the GCS measures of the mid and apical LV levels were not significant ( P = 1 and P = 0.06 , respectively). Conclusions. In our study, CA and CP severely disrupted ventricular strains. Biventricular GLS was meaningfully lower in the CA subjects. Therefore, strain analysis, especially in the longitudinal direction, could be helpful to differentiate CA from CP.

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The role of cardiac magnetic resonance imaging in the detection and monitoring of cardiotoxicity in patients with breast cancer after treatment: a comprehensive review

Cited by 19 publications

References 125 publications

The predictive role of cardiac magnetic resonance imaging in determining thalassemia patients with intermediately to highly probable pulmonary hypertension

The predictive role of cardiac magnetic resonance imaging in determining thalassemia patients with intermediately to highly probable pulmonary hypertension

Feature-tracking cardiac magnetic resonance method: a valuable marker of replacement fibrosis in hypertrophic cardiomyopathy

The Auxiliary Role of Cardiac Magnetic Resonance Feature-Tracking Parameters in the Differentiation between Cardiac Amyloidosis and Constrictive Pericarditis

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