The role of CART in islet biology

Wierup, Nils; Abels, Mia; Shcherbina, Liliya; Lindqvist, Andreas

doi:10.1016/j.peptides.2021.170708

Cited by 6 publications

(3 citation statements)

References 78 publications

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“…The coexistence of CART and DPP4 is not restricted to the spinal cord, since both of them are found in different anatomical locations such as the gastrointestinal tract, the pancreas, and blood vessels [ 43 , 44 , 45 , 46 , 47 , 48 ]. The regulatory interaction between CART and DPP4 is likely to be general and not restricted to the CNS.…”

Section: Discussionmentioning

confidence: 99%

Unique, Specific CART Receptor-Independent Regulatory Mechanism of CART(55-102) Peptide in Spinal Nociceptive Transmission and Its Relation to Dipeptidyl-Peptidase 4 (DDP4)

Kozsurek

Király

Gyimesi

et al. 2023

IJMS

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Cocaine- and amphetamine-regulated transcript (CART) peptides are involved in several physiological and pathological processes, but their mechanism of action is unrevealed due to the lack of identified receptor(s). We provided evidence for the antihyperalgesic effect of CART(55-102) by inhibiting dipeptidyl-peptidase 4 (DPP4) in astrocytes and consequently reducing neuroinflammation in the rat spinal dorsal horn in a carrageenan-evoked inflammation model. Both naturally occurring CART(55-102) and CART(62-102) peptides are present in the spinal cord. CART(55-102) is not involved in acute nociception but regulates spinal pain transmission during peripheral inflammation. While the full-length peptide with a globular motif contributes to hyperalgesia, its N-terminal inhibits this process. Although the anti-hyperalgesic effects of CART(55-102), CART(55-76), and CART(62-76) are blocked by opioid receptor antagonists in our inflammatory models, but not in neuropathic Seltzer model, none of them bind to any opioid or G-protein coupled receptors. DPP4 interacts with Toll-like receptor 4 (TLR4) signalling in spinal astrocytes and enhances the TLR4-induced expression of interleukin-6 and tumour necrosis factor alpha contributing to inflammatory pain. Depending on the state of inflammation, CART(55-102) is processed in the spinal cord, resulting in the generation of biologically active isoleucine-proline-isoleucine (IPI) tripeptide, which inhibits DPP4, leading to significantly decreased glia-derived cytokine production and hyperalgesia.

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Section: Discussionmentioning

confidence: 99%

Unique, Specific CART Receptor-Independent Regulatory Mechanism of CART(55-102) Peptide in Spinal Nociceptive Transmission and Its Relation to Dipeptidyl-Peptidase 4 (DDP4)

Kozsurek

Király

Gyimesi

et al. 2023

IJMS

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“…MIRI is closely related to oxidative stress, autophagy and apoptosis, and CART can regulate the levels of oxidative stress and apoptosis. [30][31][32][33] However, the effect of CART on MIRI and the role of CART on autophagy have not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Wang et al 30 has also reported that CART post‐processing promotes the recovery of neuronal synapses after I/R through the pleiotrophin (PTN) pathway. MIRI is closely related to oxidative stress, autophagy and apoptosis, and CART can regulate the levels of oxidative stress and apoptosis 30–33 . However, the effect of CART on MIRI and the role of CART on autophagy have not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

Cocaine and amphetamine‐regulated transcript improves myocardial ischemia–reperfusion injury through PI3K/AKT signalling pathway

Wang,

Peng

et al. 2024

Clin Exp Pharma Physio

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Myocardial ischemia–reperfusion injury (MIRI) is a common clinic scenario that occurs in the context of reperfusion therapy for acute myocardial infarction. It has been shown that cocaine and amphetamine‐regulated transcript (CART) can ameliorate cerebral ischemia–reperfusion (I/R) injury, but the effect of CART on MIRI has not been studied yet. Here, we revealed that CART protected the heart during I/R process by inhibiting apoptosis and excessive autophagy, indicating that CART would be a potential drug candidate for the treatment of MIRI. Further analysis showed that CART upregulated the activation of phospho‐AKT, leading to downregulation of lactate dehydrogenase (LDH) release, apoptosis, oxidative stress and excessive autophagy after I/R, which was inhibited by PI3K inhibitor, LY294002. Collectively, CART attenuated MIRI through inhibition of cardiomyocytes apoptosis and excessive autophagy, and the protective effect was dependent on PI3K/AKT signalling pathway.

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Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity

Charvát,

Strnadová,

Myšková

et al. 2024

European Journal of Pharmacology

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The role of CART in islet biology

Cited by 6 publications

References 78 publications

Unique, Specific CART Receptor-Independent Regulatory Mechanism of CART(55-102) Peptide in Spinal Nociceptive Transmission and Its Relation to Dipeptidyl-Peptidase 4 (DDP4)

Unique, Specific CART Receptor-Independent Regulatory Mechanism of CART(55-102) Peptide in Spinal Nociceptive Transmission and Its Relation to Dipeptidyl-Peptidase 4 (DDP4)

Cocaine and amphetamine‐regulated transcript improves myocardial ischemia–reperfusion injury through PI3K/AKT signalling pathway

Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity

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