The role of catastrophizing in sickle cell disease – The PiSCES project

Cítero, Vanessa de Albuquerque; Levenson, James L.; McClish, Donna K.; Bovbjerg, Viktor E.; Cole, Portia L.; Dahman, Bassam; Penberthy, Lynne; Aisiku, Imoigele P.; Roseff, Susan D.; Smith, Wally R.

doi:10.1016/j.pain.2007.02.008

Cited by 51 publications

(48 citation statements)

References 38 publications

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“…This suggests that prior findings that SCD patients tend to catastrophize more than other chronic pain patients [7] may be driven by a number of disease-related factors that deserve future investigation. The nature of SCD pain as related to a life-long and life-threatening disease may promote disease-related catastrophizing.…”

Section: Discussionmentioning

confidence: 91%

“…However, this elevated catastrophizing is not associated with heightened crisis or non-crisis pain intensity, distress, or pain-related interference when symptoms of depression are controlled [7]. Therefore, others have concluded that inferences about catastrophizing and pain drawn from other populations should not be translated to sickle cell pain [7]. …”

Section: Introductionmentioning

confidence: 99%

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Disease-Related, Nondisease-Related, and Situational Catastrophizing in Sickle Cell Disease and Its Relationship With Pain

Mathur

Kiley

Carroll

et al. 2016

The Journal of Pain

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Catastrophizing is a potent psychological modulator of pain across several chronic pain populations; yet despite evidence that patients with sickle cell disease (SCD) catastrophize more than patients with other chronic pain conditions, prior research indicates that catastrophizing is not related to sickle cell pain after controlling for relevant covariates such as depression. Recent research suggests that pain-related catastrophizing should be assessed across pain contexts (e.g., dispositional and situational). Here, we measured disease-specific, general non-disease related, and situational catastrophizing and assessed the relationship between these contextual dimensions of catastrophizing and both laboratory and clinical pain among patients with SCD. Results revealed differential catastrophizing across pain contexts, with patients reporting greater catastrophizing about SCD-specific pain compared to non-SCD pain and laboratory pain. SCD-specific and non-SCD catastrophizing were associated with clinical pain outcomes, and situational catastrophizing with markers of central sensitization and laboratory pain. Further examination of the time course of laboratory responses revealed that increases in situational catastrophizing were associated with subsequent increases in laboratory pain sensitivity. Taken together, results demonstrate the relevance of catastrophizing in understanding pain in SCD, and suggest that context-specific anchors may be beneficial in predicting different aspects of the pain experience (e.g., chronic pain, pain sensitization).

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Disease-Related, Nondisease-Related, and Situational Catastrophizing in Sickle Cell Disease and Its Relationship With Pain

Mathur

Kiley

Carroll

et al. 2016

The Journal of Pain

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“…1,7,21,23,26,48 PiSCES was a cohort study measuring the variability in pain and response to pain in 308 patients with SCD, 16 years of age and older. Data were collected between 2001 and 2006 from patients recruited from multiple clinical settings.…”

Section: Methodsmentioning

confidence: 99%

Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me)

Treadwell¹,

Hassell²,

Levine

et al. 2014

The Clinical Journal of Pain

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Objectives Research-derived evidence about the impact of sickle cell disease (SCD) on the lives of affected adults is lacking. We conducted formative research to provide the basis for a comprehensive description of how SCD affects the lives of adults, with the goal of developing a SCD-specific quality-of-life measurement system. Methods We conducted a comprehensive literature review of patient-reported outcomes, followed by a series of focus groups and structured individual interviews with adults with SCD (n = 122) and their health care providers (n = 15). Results We reviewed 473 abstracts and included 86 articles in the final review. The literature revealed broad categories of the impact of SCD and its treatment on the lives of adults—pain; emotional distress; social-role functioning; overall quality-of-life; and quality of care. We classified 1213 incidents from the focus groups and interviews into a taxonomy (16 domains) that met the criterion for saturation and was demonstrated to be reliable for the classification of incidents. The final conceptual model was built upon the taxonomy. Discussion Our conceptual model was similar to previous models with the effects of pain predominating, interwoven with emotional distress, quality of care, and stigmatization. We found a broad range of emotions reflected, including positive effects of SCD. Items for the quality-of-life measure were derived from the taxonomy and the conceptual model may be of use in generating hypotheses for clinical research and improving understanding for clinicians of the lived experience of adults with SCD.

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“…51 We found that SCD subjects had higher mean catastrophizing scores than those found in studies of other chronic pain conditions that are not lifelong or life-threatening. 52 Two recent studies advanced the understanding of the impact of depression on pain. 53,54 The latter study found that depressed subjects had pain on significantly more days than non-depressed subjects.…”

Section: Psychological Predictorsmentioning

confidence: 99%

“…When in pain on non-crisis days, depressed subjects had higher mean pain, higher distress from pain, and more interference from pain. 52 Over two decades ago, coping strategies among SCD adults were found to be important predictors of pain and adjustment. Individuals with high scores on the negative thinking and passive adherence categories had more severe pain, were less active and more distressed, and used more health care services.…”

Section: Psychological Predictorsmentioning

confidence: 99%

Sickle-Cell Pain: Advances in Epidemiology and Etiology

Smith

Scherer

2010

Hematology

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New epidemiological findings recast pain in sickle-cell disease (SCD) as being more often a chronic manifestation than was previously thought, although acute pain is still the hallmark of the disease. SCD pain intensity, the number of painful locations, and the frequency of hospitalizations due to SCD pain may worsen with age. In adults and even in children, the quantity and severity of SCD pain may be vastly underestimated, because most of the "iceberg" of SCD pain is "submerged" at home, and only the tip of the iceberg is seen by health care providers when acute SCD care is rendered in emergency rooms and hospitals. Implications of this "iceberg phenomenon" are significant for clinicians, researchers, employers, policy makers, and the public. Nevertheless, both emergency room and hospital utilization for SCD pain remain prevalent. Often, utilization recurs early, perhaps emblematic of poor acute pain management. New data show the protean impacts of SCD pain on health-related quality of life, sleep, and psychological and social health. The relationship of the severity of SCD pain to the severity of underlying sickle vasculopathy is unclear, but epidemiologic evidence and patient descriptors suggest a temporal evolution of pain mechanisms. At first, increasingly worse nociceptive pain from vaso-occlusion and local lesions may evolve over the first two decades of life. Then, in the third and following decades, central neuropathic pain may also evolve due to past and continuing nociceptive stimuli. New findings confirm environmental contributors to SCD pain, including seasonal (colder) temperatures, barometric pressure, and wind speed.

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The role of catastrophizing in sickle cell disease – The PiSCES project

Cited by 51 publications

References 38 publications

Disease-Related, Nondisease-Related, and Situational Catastrophizing in Sickle Cell Disease and Its Relationship With Pain

Disease-Related, Nondisease-Related, and Situational Catastrophizing in Sickle Cell Disease and Its Relationship With Pain

Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me)

Sickle-Cell Pain: Advances in Epidemiology and Etiology

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