The Role of Catecholamines in the Development of Pathological Retina Neovascularization in an Experimental Model of Retinopathy of Prematurity in Rats

Катаргина, Л. А.; Osipova, N A; Panova, A. Yu.; Petrovskaya, A. V.; Nikishina, Yu. O.; Муртазина, А. Р.; Ugrumov, M. V.

doi:10.1134/s160767291906005x

Cited by 2 publications

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“…In the experimental part of the work, data was obtained on the pathogenetic role of dopamine, L-DOPA, and norepinephrine in the development of ROP in situ and systemically [9][10][11][12]. In this article, we present more predictively significant results of the study of their systemic level in the experiment and clinic.…”

Section: Resultsmentioning

confidence: 98%

“…Also, in children with ROP, a tendency to an increase in the content of norepinephrine was revealed as the disease progressed, which indicates its pro-angiogenic properties and requires further study on a larger sample. The experiment obtained extremely interesting data regarding the precursor of dopamine L-DOPA, indicating its antiangiogenic properties in the development of pathology [9][10][11]. Moreover, a low systemic level of L-DOPA can be considered as a prognostic sign of the development of extraretinal vasoproliferation in OIR, which is the basis for planning clinical trials in order to determine the prognostic value of the L-DOPA level in the blood serum of premature infants as a potential laboratory screening criterion ROP [14].…”

Section: Discussionmentioning

confidence: 99%

“…We carried out a comprehensive clinical and experimental study, including an assessment of the local and systemic level of 49 cytokines of various biological effects, 4 monoamines and one of the most important components of the renin-angiotensin systemangiotensin-II (AT-II) at different stages of the development of the pathological process [5,[8][9][10][11][12][13][14].…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Studying the Pathogenesis of Retinopathy of Prematurity - From Theory to Practice

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Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Studying the Pathogenesis of Retinopathy of Prematurity - From Theory to Practice

La¹,

Nb²,

Nv³

et al. 2021

Act Scie Medic

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Prognostic Value Estimation of Monoamines Systemic Level in Retinopathy of Prematurity in Experiment

et al. 2021

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The aim of the investigation was to study a systemic level of L-DOPA, dopamine, and norepinephrine, and assess their prognostic value in retinopathy of prematurity (ROP) development on an experimental disease model.Materials and Methods. The investigation was carried out on infant Wistar rats (n=36) divided into a study group (rat infants with experimental ROP, n=17) and a control group (n=19). The animals of both groups were sacrificed on days 14, 21-23, and on days 28-30. The choice of the indicated periods corresponded to the key stages of ROP development in an experiment and was based on the findings of our previous histological studies. Dopamine, L-DOPA, and norepinephrine levels in infant rat blood plasma samples were determined.Results. On day 14 of the experiment (the period corresponds to the pathological neovascularization induction in the applied model and preclinical ROP in children), mean L-DOPA level in infant rats with ROP (0.31 ng/ml) was significantly decreased compared to that in the controls (0.42 ng/ml) (p≤0.01). On days 21-23 of the experiment (the period corresponds to the growth of pathological extraretinal neovascularization in the applied model and ROP stage 3 in children) the systemic level of L-DOPA was still statistically reduced in the study group (0.87 ng/ml) compared to the control group (1.53 ng/ml) (p≤0.01). On days 28-30 of the experiment (the period corresponds to the regress of neovasculature in the applied model and a spontaneous ROP regress stage in children) the L-DOPA level in blood plasma in the study group (0.33 ng/ml) showed an insignificant upward tendency in reference to the controls (0.21 ng/ml). Mean dopamine and norepinephrine levels had no difference in the groups under study of infant rats within all follow-up periods.Conclusion. Low systemic level of L-DOPA at the preclinical stage of experimental ROP should be considered as a laboratory prognostic criterion of a developing pathological process; it will enable to use the criterion when working out the measures to optimize the existing screening system for the disease in children.

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The Role of Catecholamines in the Development of Pathological Retina Neovascularization in an Experimental Model of Retinopathy of Prematurity in Rats

Cited by 2 publications

References 12 publications

Studying the Pathogenesis of Retinopathy of Prematurity - From Theory to Practice

Studying the Pathogenesis of Retinopathy of Prematurity - From Theory to Practice

Prognostic Value Estimation of Monoamines Systemic Level in Retinopathy of Prematurity in Experiment

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