The role of cathepsins H and B, and inhibitors leupeptin and CPI in proliferative activities of non-malignant cells in culture

Suhar, A.; Türk, Vito; Korbelik, Mladen; Petrović, Danilo; Škrk, Janez; Schauer, P

doi:10.1515/9783110846836-031

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Function Of the Lysosomal Cathepsins In The Organism1

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1988

1997

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“…Recent evidence supports a role for cathepsin L in reproduction . The cathepsins are probably also involved in cell differentiation and proliferation, and a role for macrophage cathepsin B in antigen processing is being discussed …”

Section: Function Of the Lysosomal Cathepsins In The Organismmentioning

confidence: 99%

Cysteine Proteases and Their Inhibitors

1997

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Section: Function Of the Lysosomal Cathepsins In The Organismmentioning

confidence: 99%

Cysteine Proteases and Their Inhibitors

1997

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Modification of Potentially Lethal Damage Repair by Some Intrinsic Intra- and Extracellular Agents: I. Proteinases and Proteinase Inhibitors

Korbelik¹,

Osmak

Suhar

et al. 1988

International Journal of Radiation Biology

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The effects of nine intra- and extracellular proteinases and six proteinase inhibitors on the repair of potentially lethal damage (PLDR) induced by gamma-rays in plateau-phase V79 cells were examined. It was demonstrated that these agents, which are intrinsic factors produced within mammalian cells, can modify PLDR activity. A stimulatory effect on PLDR was seen with calf liver neutral proteinase, and to a lesser extent, with inhibitor pepstatin A. Other proteinases which belong to serine, cysteine and aspartic superfamilies, as well as proteinase inhibitors, inhibited PLDR to different degrees. The effects of some of these agents, present during the PLDR period, on the rate of tritiated thymidine incorporation into the acid-insoluble cell fraction was also examined. They can modify the DNA synthesis of cells when subcultured from plateau phase for the assessment of colony-forming ability. There is no clear evidence that the effects observed are entirely attributed to the alteration of cellular proliferative processes. It seems more likely that many serine and cysteine proteinases and their inhibitors can adversely affect the PLDR process by modulating the activity of proteinase(s) and other enzymes involved more directly in PLDR because of interrelationships of the entire intracellular proteinase system.

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The role of cathepsins H and B, and inhibitors leupeptin and CPI in proliferative activities of non-malignant cells in culture

Cited by 2 publications

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Cysteine Proteases and Their Inhibitors

Cysteine Proteases and Their Inhibitors

Modification of Potentially Lethal Damage Repair by Some Intrinsic Intra- and Extracellular Agents: I. Proteinases and Proteinase Inhibitors

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