The role of CD56bright NK cells in neurodegenerative disorders

Rodriguez-Mogeda, Carla; van Ansenwoude, Chaja M. J.; van der Molen, Lennart; Strijbis, Eva M. M.; Mebius, Reina E.; de Vries, Helga E.

doi:10.1186/s12974-024-03040-8

Cited by 6 publications

(3 citation statements)

References 235 publications

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“…NK cells can be divided into CD56(bright) and CD56(dim) according to the expression of CD56 on their surfaces [ 16 ]. Among them, CD56(bright) NK cells mainly play an anti-tumor immune role by secreting cytokines such as INF-γ and TNF-β [ 17 ].…”

Section: Nk Cell Research Advancements In Immunotherapy and Imagingmentioning

confidence: 99%

Research Progress of Nanomaterials Acting on NK Cells in Tumor Immunotherapy and Imaging

Feng,

Zhang,

Shao

et al. 2024

Biology

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The prognosis for cancer patients has declined dramatically in recent years due to the challenges in treating malignant tumors. Tumor immunotherapy, which includes immune target inhibition and chimeric antigen receptor cell treatment, is currently evolving quickly. Among them, natural killer (NK) cells are gradually becoming another preferred cell immunotherapy after T cell immunotherapy due to their unique killing effects in innate and adaptive immunity. NK cell therapy has shown encouraging outcomes in clinical studies; however, there are still some problems, including limited efficacy in solid tumors, inadequate NK cell penetration, and expensive treatment expenses. Noteworthy benefits of nanomaterials include their chemical specificity, biocompatibility, and ease of manufacturing; these make them promising instruments for enhancing NK cell anti-tumor immune responses. Nanomaterials can promote NK cell homing and infiltration, participate in NK cell modification and non-invasive cell tracking and imaging modes, and greatly increase the effectiveness of NK cell immunotherapy. The introduction of NK cell-based immunotherapy research and a more detailed discussion of nanomaterial research in NK cell-based immunotherapy and molecular imaging will be the main topics of this review.

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Section: Nk Cell Research Advancements In Immunotherapy and Imagingmentioning

confidence: 99%

Research Progress of Nanomaterials Acting on NK Cells in Tumor Immunotherapy and Imaging

Feng,

Zhang,

Shao

et al. 2024

Biology

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“…NK cells can be divided into CD56(bright) and CD56(dim) according to the expression of CD56 on their surfaces [16]. Among them, CD56(bright) NK cells mainly play an antitumor immune role by secreting cytokines such as INF-γ and TNF-β [17].…”

Section: Nk Cell Classification and Subsetsmentioning

confidence: 99%

Research Progress of NK Cell-Based Nanomaterials in Tumor Immunotherapy and Imaging

Feng,

Zhang,

Shao

et al. 2024

Preprint

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Tumor immunotherapy represented by immune target blocking and chimeric antigen receptor cell therapy has developed rapidly. Among them, Natural Killer Cell (NK) is gradually becoming another preferred immunotherapy method after T cell immunotherapy because of its unique killing effect in innate immunity and adaptive immunity. Although NK cell therapy has achieved promising results in clinical trials, there are still some problems, such as low efficacy in solid tumors, insufficient penetration of NK cells and high cost of treatment. Nanomaterials are expected to be an excellent tool to improve the anti-tumor immune response of NK cells due to their advantages such as chemical specificity, biocompatibility and simple synthesis. Nanomaterials can enhance the cytotoxicity of NK cells, participate in the modification and noninvasive cell-tracking patterns of NK cells，and mediate their homing and infiltration, and thus significantly improve the efficiency of NK cell immunotherapy. In this review, we will briefly introduce the methods and mechanisms of tumor immunotherapy, emphasize the research progress of NK cell-based immunotherapy and imaging, and finally summarize the direction and research progress of nanomaterials in NK cell-based immunotherapy.

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“…53 In PD, cytotoxic cells may also contribute to neuroinflammation and neuronal damage. 54 The dysregulation of cytotoxic cells in PD combined with COVID-19 patients could exacerbate neurodegeneration and worsen the clinical outcomes. Neutrophils are the most abundant type of white blood cells and play a key role in the innate immune response.…”

mentioning

confidence: 99%

Role of Inflammation in the Development of COVID-19 to Parkinson’s Disease

Liu,

Wu,

Sun

et al. 2024

JIR

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Background:The coronavirus disease 2019 (COVID-19) can lead to neurological symptoms such as headaches, confusion, seizures, hearing loss, and loss of smell. The link between COVID-19 and Parkinson's disease (PD) is being investigated, but more research is needed for a definitive connection. Methods: Datasets GSE22491 and GSE164805 were selected to screen differentially expressed gene (DEG), and immune infiltration and gene set enrichment analysis (GSEA) of the DEG were performed. WGCNA analyzed the DEG and selected the intersection genes. Potential biological functions and signaling pathways were determined, and diagnostic genes were further screened using gene expression and receiver operating characteristic (ROC) curves. Screening and molecular docking of ibuprofen as a therapeutic target. The effectiveness of ibuprofen was verified by constructing a PD model in vitro, and constructing "COVID19-PD" signaling pathway, and exploring the role of angiotensin-converting enzyme 2 (ACE2) in PD. Results: A total of 13 DEG were screened from the GSE36980 and GSE5281 datasets. Kyoto encyclopedia of genes and genomes (KEGG) analysis showed that the DEG were mainly associated with the hypoxia-inducible factor (HIF-1), epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance, etc. After analysis, it is found that ibuprofen alleviates PD symptoms by inhibiting the expression of nuclear factor kappa-B (NF-κB), interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α). Based on signal pathway construction, the importance of ACE2 in COVID-19-induced PD has been identified. ACE2 is found to have widespread distribution in the brain. In the 1-methyl-4-phenyl-1,2,3,6-te-trahydropyridine (MPTP)-induced ACE2-null PD mice model, more severe motor and non-motor symptoms, increased NF-κB p65 and α-synuclein (α-syn) expression with significant aggregation, decreased tyrosine hydroxylase (TH), severe neuronal loss, and neurodegenerative disorders. Conclusion: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection increases the risk of PD through an inflammatory environment and downregulation of ACE2, providing evidence for the molecular mechanism and targeted therapy associated with COVID-19 and PD.

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The role of CD56bright NK cells in neurodegenerative disorders

Cited by 6 publications

References 235 publications

Research Progress of Nanomaterials Acting on NK Cells in Tumor Immunotherapy and Imaging

Research Progress of Nanomaterials Acting on NK Cells in Tumor Immunotherapy and Imaging

Research Progress of NK Cell-Based Nanomaterials in Tumor Immunotherapy and Imaging

Role of Inflammation in the Development of COVID-19 to Parkinson’s Disease

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