The Role of CD8 T Cells in the Control of Infectious Disease and Malignancies

Hsu, Shiou-Chih

doi:10.1002/9780470688618.taw0103

Cited by 1 publication

(1 citation statement)

References 187 publications

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“…Genetic vaccination could present MHC class Ⅰrestricted antigens to CD8 T lymphocytes via both endogenous and alternative routes of exogenous processing pathways. The same as live attenuated vaccines as well as recombinant vector-delivered vaccines, the genetic vaccination is able to induce effective cellular responses, in particular for virusspecific CD8 T lymphocyte responses (47). DNA vaccines have been exploited in current use for domesticated animals and wildlife for a while.…”

Section: Genetic Vaccinationmentioning

confidence: 99%

Vaccination-Associated Pathogenesis

Chang,

Chi,

Yang

et al. 2024

Preprint

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Vaccination represents the historical milestone in medical sciences, which has been saving millions of lives. Nonetheless, continued outbreaks of emergent infectious diseases are swamping from every coast to every border all over the world. Modern vaccines are our most powerful arsenals to defend the public health of a global population ever since 1796. As unexpected, modern vaccination approaches have brought out all sorts of unwelcome pathogenic disorders to varying extents. Pathogenic viruses have also continued to evolve to defeat elaborate arsenals devised by human intelligence. In this review, we have covered a variety of vaccination approaches along with their sophisticated materials from the past to the most recent development. Furthermore, we discuss varied serious pathogenic outcomes elicited by contemporary vaccination programmes involving novel materials in real clinical trials. The complex immune mediators will be discussed in the context to tackle the complication of vaccine-induced pathogenesis. We will offer the insight into the intractable discrepancy of vaccine-associated pathology. The precision approach bestowed with evolutionary concepts will be considered as a feasible option to confront various issues of pathogenic complicacy.

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Section: Genetic Vaccinationmentioning

confidence: 99%