The role of central nervous system on hypoglycemia and the feasibility of the brain theory in traditional Chinese medicine on treatment of diabetes mellitus

Jiang, Hanqiu; Niu, Jingjing; Zhang, Weifei; Huang, Weidong; Zhou, Mingyue; Sha, Wenjun; Li, Junyan; Li, Fufeng; Zhu, Ting; Xia, Xin; Zhang, Jun; Yuan-dong, Shen; Zhou, Ligang

doi:10.1016/s2095-4964(14)60008-x

Cited by 8 publications

(4 citation statements)

References 46 publications

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“…In the present study, the aim is to investigate the effects and mechanism of anti-diabetic function of ZS. Pancreatic β-cell failure plays a major role in the progress and development of T2DM (Jiang et al, 2014;Liu et al, 2017). Islet fibrosis may be an important result of progressive β-cell failure because it may accelerate the destruction of β-cells, such as that in chronic pancreatitis, or destroy β-cell (Gamble et al, 2004;Garner et al, 2004;.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice

et al. 2022

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To evaluate the effectiveness of regulating insulin sensitivity via the insulin receptor substrate-1 of Zingiber striolatum bud extract in C57BL/KsJ-db/db mice. The C57BL mice were randomly divided into 5 groups (n=10), including normal control group, model group, metformin group, ZS-l (ZS low dose) group, and ZS-h (ZS high dose) group. The body weight and blood glucose were determined weekly. The oral glucose tolerance test, plasma insulin and biochemical parameters, pancreas histopathology, and the expression of insulin receptor substrate-1 were assayed at the end of experimental point. The results showed that Z. striolatum bud extract can significantly decrease the fasting blood glucose and glycated hemoglobin levels and insulin resistance (HOMA-IR) in C57BL mice. Western blot analysis demonstrated Z. striolatum bud extract could regulate the insulin sensitivity by upregulating the express of phospho-insulin receptor substrate-1. In conclusion, Z. striolatum bud extract could prevent the progression of diabetes and pancreatic fibrosis in C57BL mice.

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Section: Discussionmentioning

confidence: 99%

Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice

et al. 2022

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“…The risk of combining herbal and conventional medicines for DM patients Pharmacy Education 23(4) 185 -188 186 could be toxic to them (Amjad et al, 2019). Some herbal medicine even causes hypoglycemia (Goksu et al, 2010) which can increase the risk of complications, such as heart disease and diabetic peripheral neuropathy in people with DM (Jiang et al, 2014).…”

Section: Rahem Et Almentioning

confidence: 99%

The risk of combined use of herbal and conventional medicines in diabetic patients

Rahem,

Athiyah,

Setiawan

et al. 2023

Pharm Educ

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Background: The prevalence of diabetes mellitus (DM) continues to increase due to changes in human lifestyle. Adherence to taking medication becomes one of the keys to successful blood glucose control. Unfortunately, not all people with DM are obedient to take medicine because of various reasons, such as fear of the side effects. To avoid some concerns about medicine, some prefer to add herbal medicine. Objective: This study determined whether the addition of herbal medicine to conventional drugs increases the incidence of hypoglycemia. Methods: This study was carried out from October 2019-March 2020 on 350 Madurese patients with DM in 33 primary healthcare centres of Madura. Data were collected using a valid and reliable questionnaire. The independent variable in this study was the use of herbal medicine, while the dependent variable was the incidence of hypoglycemia. Results: About 41.4% of respondents used herbal medicine in addition to conventional drugs. Among those who consumed herbal medicine, 59.3% experienced hypoglycemia, while 24.4% did not take herbal medicine. The results showed a significant relationship between the use of herbal medicine and the incidence of hypoglycemia with a p-value of 0.0001. Conclusion: The use of herbal medicine increased the incidence of hypoglycemia.

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“…LXRs play essential roles in the regulation of cholesterol, triglycerides, fatty acids, and glucose homeostasis (Baranowski, 2008). LXR agonists may lower cholesterol by inducing target gene expression (Beyea et al, 2007;Jiang et al, 2014;Terasaka et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling

Guo

Gao

Zhang

et al. 2015

Pharmaceutical Biology

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(2016) Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling, Pharmaceutical Biology, 54:8, 1312-1325, DOI: 10.3109/13880209.2015 Objective: The objective of this study is to investigate the antiobesity and lipid-lowering effects of sea cucumber extracts in in vitro and in vivo models and elucidate the mechanism of action of the extracts on obesity and dyslipidemia. Materials and methods: The 60% ethanol extracts from the body walls of 10 different sea cucumbers were investigated for the inhibition of pancreatic lipase (PL) activity in vitro. The optimal active extract (SC-3) was further chemically analyzed by LC-MS and UV. And 0.1% and 0.2% of SC-3 was mixed with a high-fat diet to treat C57/BL6 mice for 6 weeks or 2 weeks as preventive and therapeutic study. The body weight, serum, and liver lipid profile in the mice were investigated. Results: The crude extract of Pearsonothuria graeffei Semper (Holothuriidae) inhibited the PL activity by 36.44% of control at 0.5 mg/mL. SC-3 and echinoside A inhibited PL with an IC 50 value at 2.86 mg/ mL and 0.76 mM. 0.1% of SC-3 reduced the body weight (23.0 ± 0.62 versus 26.3 ± 0.76 g), the serum TC (2.46 ± 0.04 versus 2.83 ± 0.12 mmol/L), TG (0.19 ± 0.08 versus 0.40 ± 0.03 mmo/L), and LDL-c (0.48 ± 0.02 versus 0.51 ± 0.02 mmol/L), and liver TC (1.19 ± 0.17 versus 1.85 ± 0.13 mmol/mg) and TG (6.18 ± 0.92 versus 10.87 ± 0.97 mmol/mg) contents of the obese C57BL/six mice on a high-fat diet. Discussion and conclusion: Sea cucumber may be used for developing antiobesity and antihyperlipidemia drugs. ARTICLE HISTORY

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The role of central nervous system on hypoglycemia and the feasibility of the brain theory in traditional Chinese medicine on treatment of diabetes mellitus

Cited by 8 publications

References 46 publications

Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice

Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice

The risk of combined use of herbal and conventional medicines in diabetic patients

Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling

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