Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of maternal ACEs, and their interaction with financial stress and discrimination, with methylation status within eight differentially methylated regions (DMRs) in imprinted domains in newborns. ACEs, financial stress during pregnancy, and experience of discrimination were self-reported among 232 pregnant women. DNA methylation was assessed at
PEG10
/
SGCE, NNAT, IGF2, H19, PLAGL1
,
PEG3
,
MEG3-IG
, and
DLK1/MEG3
regulatory sequences using pyrosequencing. Using multivariable linear regression models, we found evidence to suggest that financial stress was associated with hypermethylation of
MEG3-IG
in non-Hispanic White newborns; discrimination was associated with hypermethylation of
IGF2
and
NNAT
in Hispanic newborns, and with hypomethylation of
PEG3
in non-Hispanic Black newborns. We also found evidence that maternal ACEs interacted with discrimination to predict offspring
PLAGL1
altered DMR methylation, in addition to interactions between maternal ACEs score and discrimination predicting
H19
and
SGCE/PEG10
altered methylation in non-Hispanic White newborns. However, these interactions were not statistically significant after multiple testing corrections. Findings from this study suggest that maternal ACEs, discrimination, and financial stress are associated with newborn aberrant methylation in imprinted gene regions.