The role of chlamydial antibodies in an in vitro fertilization program

Torode, Hugh; Wheeler, Penny A.; Saunders, Douglas M.; McPetrie, Rosemary; Medcalf, S.C.; Ackerman, V.P.

doi:10.1016/s0015-0282(16)59596-x

Cited by 33 publications

(13 citation statements)

References 10 publications

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“…A profound number of other investigators [1,[5][6][7] were not been able to demonstrate a decrease in pregnancy rates in the presence of serum anti-C. trachomatis IgG. In association with their results, in current study IVF outcome, expressed by clinical pregnancy, life birth and miscarriage rates, was unrelated to anti-chlamydial antibody status of TFI patients.…”

Section: Discussionsupporting

confidence: 60%

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Association between anti-chlamydial immunity and IVF outcome

Müller¹,

Savicheva²,

Kogan³

et al. 2015

Gynecological Endocrinology

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Background: Elevated antibody titers to Chlamydia trachomatis are detected in up to 70% of women with tubal factor infertility (TFI). In order to evaluate the influence of past chlamydial infection on the results of IVF treatment, a prospective cohort study was performed. Materials and methods: A total of 242 women with TFI were enrolled in the study. Serum samples (n ¼ 242) and follicular fluid (n ¼ 197) were analyzed using enzyme-linked immunosorbent assay for anti-C. trachomatis IgG, IgA, IgM and anti-chlamydial heat shock protein 60 kDa IgG. Results: ''Poor response'' to ovarian stimulation was two times more frequent in seropositive subjects (22.9% versus 13.3%, p ¼ 0.039). Seropositive and seronegative women had similar IVF outcomes, expressed by clinical pregnancy (20.5% versus 25.0%), life birth (13.1% versus 20.0%) and miscarriage rates (36.0% versus 16.7%, p ¼ 0.092). Incidence of missed abortion after IVF was higher in women with previous exposure to C. trachomatis (28.0%) as compared to those without antibodies (3.3%), p ¼ 0.018. Conclusions: Anti-chlamydial antibody detection is not related to oocyte maturity, embryo quality, pregnancy and life birth rates. However, past chlamydial infection in TFI patients is associated with decreased IVF success: ''poor response'' to ovarian stimulation and missed abortion rate.

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Section: Discussionsupporting

confidence: 60%

“…Liccardi et al [4] established an association between chlamydial antibody positivity in serum and spontaneous abortion. In contrast, no relation between anti-chlamydial immunity and IVF failure was documented in comparable number of publications [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Association between anti-chlamydial immunity and IVF outcome

Müller¹,

Savicheva²,

Kogan³

et al. 2015

Gynecological Endocrinology

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“…Circulating anti-chlamydial IgG has also been associated with IVF failures 23,25,26 in some studies but not others. 27 These studies were all performed prior to the knowledge that immunity to the chlamydial hsp60 induces pro-inflammatory responses. A recent review on the possible influence of immunity to hsp60 and infertility has been published.…”

Section: Immunity To C Trachomatis Hsp60 and Pregnancy Outcomementioning

confidence: 99%

Chlamydia trachomatis infection, immunity, and pregnancy outcome

Witkin

Neuer

Giraldo

et al. 1997

Infect. Dis. Obstet. Gynecol.

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Chlamydia trachomatis can ascend from the cervix to the fallopian tubes and survive for long periods of time without causing symptoms. The immune response to infection clears the extracellular organisms but leads to development of a persistent intracellular infection. Repeated cycles of productive infection and persistence eventually induce tubal occlusion and infertility. Persistently infected cells continue to synthesize the chlamydial 60 kD heat shock protein (hsp60). Immunity to conserved regions of hsp60 may result in autoimmunity to human hsp60. Expression of hsp60 by the embryo and decidua during early pregnancy may reactivate hsp60‐sensitized lymphocytes, disturb pregnancy‐induced immune regulatory mechanisms, and lead to immune rejection of the embryo. Due to this mechanism women with tubal infertility who are sensitized to the human hsp60 may have a decreased probability of successful outcome after undergoing in vitro fertilization and embryo transfer. Infect. Dis. Obstet. Gynecol. 5:128–132, 1997. © 1997 Wiley‐Liss, Inc.

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“…Some studies have revealed a decreased pregnancy rate in the presence of chlamydial antibodies [9,10], while others have not [11]. At least some of those studies were per formed using the IPA method.…”

Section: Discussionmentioning

confidence: 99%

Positive Serology for Chlamydia: Is It Always forChlamydia trachomatis?

Katz¹,

Levy²,

Lurie³

1995

Gynecol Obstet Invest

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In this study we tried to determine the factual prevalence of Chlamydia trachomatis seropositive women. Sera of 174 sexually active women of reproductive age who attended the emergency room in our gynecology department were tested by both a species-specific solid-phase enzyme immunoassay (SPEIA, ImmunoComb, Orgenics, Israel) and by an immunoperoxidase assay (IPA). One-hundred and twenty-two of 174 women (70.1%) tested were found positive for C trachomatis by the IPA test. The SPEIA test identified 41 (33.6%) of those as positive for C. trachomatis and 81 (66.4%) positive for C. pneumoniae. We conclude that the currently used IPA method for chlamydia diagnosis overestimates C. trachomatis infection and its specificity for the diagnosis of C. trachomatis is limited. By using the SPEIA test, it is possible to distinguish between C. trachomatis and C. pneumoniae seropositivity.

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The role of chlamydial antibodies in an in vitro fertilization program

Cited by 33 publications

References 10 publications

Association between anti-chlamydial immunity and IVF outcome

Association between anti-chlamydial immunity and IVF outcome

Chlamydia trachomatis infection, immunity, and pregnancy outcome

Positive Serology for Chlamydia: Is It Always forChlamydia trachomatis?

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