The Role of Chronic Exposure to Amoxicillin/Clavulanic Acid on the Developmental Enamel Defects in Mice

Mihalaș, Eugeniu; Matricala, Lavinia; Chelmuș, Alina; Gheţu, Nicolae; Petcu, Ana; Pașca, Sorin Aurelian

doi:10.1177/0192623315610822

Cited by 26 publications

(31 citation statements)

References 36 publications

(60 reference statements)

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“…There are some disadvantages when using these materials: doubtable adaptation to the cavity walls [1], voids formation in the bulk material [2] and difficulties when displacing the material from the syringe. In the complex environment of oral cavity, these materials are prone to degradation [3][4][5][6][7] and the tooth-material adhesion to breaking. Efforts were made in time in order to improve marginal adaptation of these composite resins, by controlling the polymerization shrinkage [8][9][10], by placing a flowable composite resin as an intermediate layer [11] or by reducing the viscosity of these highly filled composite using preheating [12][13][14][15].…”

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confidence: 99%

Evaluation of Pre-heating Effects on Marginal Adaptation of Resin-based Materials

Taraboanta¹,

Stoleriu²,

Iovan³

et al. 2018

Mat.Plast.

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The aim of the study was to compare the marginal adaptation of three different resin-based materials used for direct restoration: hybrid composite resin (Gaenial Posterio, GC Corporation), a compomer (Dyract eXtra, Dentsply Sirona), and a giomer (Beautifil II, Shofu Dental) applied at room temperature or after preheated at preheating 50 and 60oC. Class II cavities were prepared on proximal surfaces of extracted teeth and randomly divided in 3 groups according to the material used for restoration. In each group five cavities were restored using the materials at room temperature (subgroup 1), five cavities were restored using preheated materials at 50şC (subgroup 2), and five cavities were restored using preheated materials at 60şC (subgroup 3). The teeth were stored in distilled water for 14 days and then were immersed in 2% methylene blue buffered dye solution (pH = 7) for 4 hours. The teeth were transversally cut and the sections were examined using optical microscope (Carl-Zeiss AXIO Imager A1m) at 50x magnification and the dye penetration was evaluated according to 4 scores. Decreased microleakage and fewer gap formation were recorded for all filling materials after they have been heated at 50 or 60oC. Pre-warming of resin-based materials improves the adaptation of these materials to tooth structures.

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mentioning

confidence: 99%

Evaluation of Pre-heating Effects on Marginal Adaptation of Resin-based Materials

Taraboanta¹,

Stoleriu²,

Iovan³

et al. 2018

Mat.Plast.

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“…An important role in cervical dentinal hypersensitivity is also periodontal therapy. Thus, through root planning, the root dental surface may suffer significant losses of minerals with the appearance of HD [10][11][12][13][14][15].…”

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confidence: 99%

The Assessment of the Effectiveness of Remineralization and Laser Therapy in Cervical Dentine Hypersensitivity

Ghiorghe¹,

Dimbu²,

Ţîrcă³

et al. 2018

Rev. Chim.

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The aim of study was to compare the clinical effectiveness of 810nm laser therapy, remineralising therapy with MI PASTE PLUS� (GC), and toothbrush with Sensodyne� Repair&Protect (GSK) in cervical dentine hypersensitivity. The study was performed on 60 subjects (34 females, 24 males), with at least one tooth affected by cervical dentine hypersensitivity. The patients were randomly divided in three study groups (20 subjects for each group), related to the type of desensitizing therapy: 810nm laser therapy, remineralising therapy with gel MI PASTE PLUS�, toothbrushing with Sensodyne� Repair&Protect). The assessment of the therapy effectiveness was performed by analysis of Schiff Cold Air Sensitivity Scale, with scores directly related to the level of dentine hypersensitivity. For laser group the scores decreased from 2.25 at baseline, at 1.35 at 3 days, and 0.2 at 7 days, with significant statistical differences at 3 days, and 7 days comparing with baseline. For MI PASTE PLUS� (GC) study group the scores decreased from 2.20 at baseline, at 1.60 at 3 days, and 1.30 at 7 days, with significant statistical differences at 3 days, and 7 days comparing with baseline. For Sensodyne� Repair&Protect (GSK) study group the scores decreased from 2.15 at baseline, at 1.90 at 3 days, and 1.45 at 7 days, with significant statistical differences at 3 days, and 7 days comparing with baseline. Low level laser therapy showed better reduction in cervical hypersensitivity, followed by the therapy using MI PASTE PLUS� (GC) gel, and by the toothbrush with Sensodyne� Repair&Protect (GSK) toothpaste.

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“…The enamel is the most mineralized tissue in mammals and it is composed in a proportion of over 97% by minerals, mostly in the form of calcium phosphates. Ca/P ratio in healthy enamel varies between 1.64 and 1.8, similar to that of apatite [17,18].…”

Section: Resultsmentioning

confidence: 84%

In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel

Mihalaș¹,

Ogodescu²,

Bălan³

et al. 2017

Rev. Chim.

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The aim of this study was to assess the morphological and chemical composition changes induced by the chronic intake of sodium fluoride (NaF) and Amoxicillin in mice enamel. 35 C57BL/6 adult male mice, were randomly divided into a control and 4 treatment groups (n = 7). After acclimatization, the experimental groups were simultaneously treated with 25 ppm (group 2 and 3) and 50ppm (group 4 and 5) of NaF, and 50mg/kg BW (group 2 and 4) and 100 mg/kg BW (group 3 and 5) of Amoxicillin as Amoxicillin/clavulanic acid (AMC). NaF was supplied through drinking water without restricting access, and AMC administered through subcutaneous injection, once per day, for 60 days. After harvesting, lower incisors� enamel was subjected to a scanning electron microscope (SEM) and to an energy dispersive X-ray analysis (EDX). In the treatment groups, SEM and EDX analysis in treatment groups showed an increasing trend of weight percentage (wt%) for C, N, O, F, Na and C/O, F/Fe ratio, and also a decreasing trend of wt% for P, Cl, Ca, Fe and Ca/P ratio. Morphological changes ranged from fissures and short grooves with pits-like appearance, in group 2 sometimes associated with limited demineralized areas looking like irregular scratches, up to demineralized areas extended in the outer enamel, which in group 5 gives the enamel the corroded look. The severity of the morphological changes in the mice enamel varied with the supplied dose of NaF and AMC, and had a uniform pattern in each experimental group. SEM analysis revealed a hypoplasia on the outer enamel and EDX analysis showed a hypomineralisation at the level of the outer enamel.

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The Role of Chronic Exposure to Amoxicillin/Clavulanic Acid on the Developmental Enamel Defects in Mice

Cited by 26 publications

References 36 publications

Evaluation of Pre-heating Effects on Marginal Adaptation of Resin-based Materials

Evaluation of Pre-heating Effects on Marginal Adaptation of Resin-based Materials

The Assessment of the Effectiveness of Remineralization and Laser Therapy in Cervical Dentine Hypersensitivity

In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel

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