The role of chronic mucosal trauma in oral cancer: A review of literature

Singhvi, Hitesh; Malik, Akshat; Chaturvedi, Pankaj

doi:10.4103/0971-5851.203510

Cited by 62 publications

(25 citation statements)

References 41 publications

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“…The risk factors are well-known: smoking [ 3 ] and alcohol [ 4 ], which are considered modifiable major risk factors; others include the human papillomavirus (HPV) [ 5 , 6 ], poor oral hygiene [ 7 ], and chronic injuries of the mucosa [ 8 ]. Moreover, OSCC is easy detectable [ 9 ], thanks to the ease of inspection of the oral cavity and the frequent previous occurrence of oral potentially malignant disorders (OPMDs) including leukoplakia and erythroplakia, which are the most common ones [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

A Snapshot of Knowledge about Oral Cancer in Italy: A 505 Person Survey

Nocini

Marchioni

Zotti

2020

IJERPH

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Objectives: Patients’ knowledge about oral squamous cell carcinoma (OSCC) plays an important role in primary prevention, early diagnosis, and prognosis and survival rate. The aim of this study was to assess OSCC awareness attitudes among general population in order to provide information for educational interventions. Methods: A survey delivered as a web-based questionnaire was submitted to 505 subjects (aged from 18 to 76 years) in Italy, and the answers collected were statistically analyzed. Information was collected about existence, incidence, features of lesions, risk factors of oral cancer, and self-inspection habits, together with details about professional reference figures and preventive behaviors. Results: Chi-square tests of independence with adjusted standardized residuals highlighted correlations between population features (age, gender, educational attainment, provenance, medical relationship, or previous diagnoses of oral cancer in family) and knowledge about oral cancer. Conclusions: Knowledge about OSCC among the Italian population is limited, and it might be advisable to implement nudging and sensitive customized campaigns in order to promote awareness and therefore improve the prognosis of this disease.

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Section: Introductionmentioning

confidence: 99%

A Snapshot of Knowledge about Oral Cancer in Italy: A 505 Person Survey

Nocini

Marchioni

Zotti

2020

IJERPH

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“…Many epidemiological studies have reported that chronic and heavy alcohol consumption, as well as poor oral hygiene, are strongly correlated with oral cancer 1–4 . However, in vitro studies have indicated that ethanol itself is not carcinogenic 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Metabolic property of acetaldehyde production from ethanol and glucose by oral Streptococcus and Neisseria

Tagaino

Washio

Abiko

et al. 2019

Sci Rep

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Acetaldehyde is known to be carcinogenic and produced by oral bacteria. Thus, bacterial acetaldehyde production might contribute to oral cancer. Therefore, we examined bacterial acetaldehyde production from ethanol and glucose under various conditions mimicking the oral cavity and clarified the metabolic pathways responsible for bacterial acetaldehyde production. Streptococcus mitis , S . salivarius , S . mutans , Neisseria mucosa and N . sicca were used. The bacterial metabolism was conducted at pH 5.0–8.0 under aerobic and anaerobic conditions. The production of acetaldehyde and organic acids was measured with gas chromatography and HPLC, respectively. Bacterial enzymes were also assessed. All of the bacteria except for S . mutans exhibited their greatest acetaldehyde production from ethanol at neutral to alkaline pH under aerobic conditions. S . mutans demonstrated the greatest acetaldehyde from glucose under anaerobic conditions, although the level was much lower than that from ethanol. Alcohol dehydrogenase and NADH oxidase were detected in all of the bacteria. This study revealed that oral indigenous bacteria, Streptococcus and Neisseria can produce acetaldehyde, and that such acetaldehyde production is affected by environmental conditions. It was suggested that alcohol dehydrogenase and NADH oxidase are involved in ethanol-derived acetaldehyde production and that the branched-pathway from pyruvate is involved in glucose-derived acetaldehyde production.

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“…In this study most patients were not associated with any dental factors. According to the study by (Chaturvedi et al, 2017) there is not enough available evidence which appears to be signi icant enough to support sharp teeth to be a risk factor in causing oral cancer. Many times, during the examination of oral cancer patients, we come across a sharp tooth at corresponding location on the alveolar arch.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Non-tobacco Associated Tongue Squamous Cell Carcinoma - Retrospective Study

Ushanthika

Sherlin

M.Sivakumar

2020

ijrps

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OTSCC is the most occurring cancer diagnosed in the oral cavity worldwide. There has been a rise in the occurrence of carcinoma of the tongue, especially among non-alcohol and non-tobacco users. The aim of the study is to assess the prevalence of non tobacco tongue OSCC and to correlate with the dental factors. The retrospective analysis data was collected from the dental hospital management system records of Saveetha dental college in OSCC patients without any habits from June 2019 to March 2020. The Clinical details, history and dental factors were tabulated and analysed using statistical software SPSS. Fifteen cases of OTSCC were found to be not associated with any tobacco or alcohol habits. The most prevalent age was from 51 to 60 years and more common in males. The most common site was the lateral border of the tongue. 73% of the patients were not associated with any dental factor and the most common histopathological grade was WDSCC 66%. 60% of the patients had been diagnosed with stage III OTSCC. Within the limits of this study, there is a high prevalence of WDSCC in tongue OSCC in the lateral border of tongue in male between the age group of 51-60 years commonly in males. There was not much association seen with dental factors. The present study underlines the importance of in depth analysis of other etiological factors in OTSCC, thereby facilitating a better understanding of the biology and progression.

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The role of chronic mucosal trauma in oral cancer: A review of literature

Cited by 62 publications

References 41 publications

A Snapshot of Knowledge about Oral Cancer in Italy: A 505 Person Survey

A Snapshot of Knowledge about Oral Cancer in Italy: A 505 Person Survey

Metabolic property of acetaldehyde production from ethanol and glucose by oral Streptococcus and Neisseria

Prevalence of Non-tobacco Associated Tongue Squamous Cell Carcinoma - Retrospective Study

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