The role of ciliopathy-associated type 3 adenylyl cyclase in infanticidal behavior in virgin adult male mice

Type III adenylyl cyclase is essential for follicular development in female mice and their reproductive lifespan

“…Reportedly, Adcy3 is expressed in the cilia of neuronal cells, including olfactory cells, and plays essential roles in olfaction and other physiological processes in mammals. 34 , 36 , 37 , 38 However, its physiological role in female ovarian function has not been fully elucidated. Here, we demonstrated that mice lacking Adcy3 exhibited a progressive loss of ovarian follicles and accelerated oocyte aging, a phenotype that is reminiscent of typical human POF.…”