The role of cine MR imaging in the assessment of uterine function

Soares, Deborah Monteiro; Werner, Heron; Bittencourt, Leonardo Kayat; Lopes, Flávia Paiva Proença Lobo; Oliveira, Marco Aurélio Pinho

doi:10.1007/s00404-019-05222-9

Cited by 10 publications

(14 citation statements)

References 48 publications

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“…Inflammation may impair the physiological clearance of senescent decidual cells and turn into a chronic process resulting in defective functionality [50]. Inflammatory elements observed in the DHEA group may promote DHEA-related muscle fibrosis [40,51], a condition known to affect contractility and peristalsis by interfering with sperm and embryo transport and the maintenance of early pregnancy [52]. Overall, based on these observations, the PCOS uterus phenotype may resemble the aging uterine phenotype as described in preclinical models [50].…”

Section: Discussionmentioning

confidence: 96%

Modulating Morphological and Redox/Glycative Alterations in the PCOS Uterus: Effects of Carnitines in PCOS Mice

et al. 2023

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(1) Background: Polycystic ovarian syndrome (PCOS) is a common and multifactorial disease affecting reproductive-age women. Although PCOS ovarian and metabolic features have received extensive research, uterine dysfunction has been poorly investigated. This research aims to investigate morphological and molecular alterations in the PCOS uterus and search for modulating effects of different carnitine formulations. (2) Methods: CD1 mice were administered or not with dehydroepiandrosterone (DHEA, 6 mg/100 g body weight) for 20 days, alone or with 0.40 mg L-carnitine (LC) and 0.20 mg acetyl-L-carnitine (ALC) in the presence or absence of 0.08 mg propionyl-L-carnitine (PLC). Uterine horns from the four groups were subjected to histology, immunohistochemistry and immunoblotting analyses to evaluate their morphology, collagen deposition, autophagy and steroidogenesis. Oxidative-/methylglyoxal (MG)-dependent damage was investigated along with the effects on the mitochondria, SIRT1, SOD2, RAGE and GLO1 proteins. (3) Results: The PCOS uterus suffers from tissue and oxidative alterations associated with MG-AGE accumulation. LC-ALC administration alleviated PCOS uterine tissue alterations and molecular damage. The presence of PLC prevented fibrosis and maintained mitochondria content. (4) Conclusions: The present results provide evidence for oxidative and glycative damage as the main factors contributing to PCOS uterine alterations and include the uterus in the spectrum of action of carnitines on the PCOS phenotype.

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Section: Discussionmentioning

confidence: 96%

Modulating Morphological and Redox/Glycative Alterations in the PCOS Uterus: Effects of Carnitines in PCOS Mice

et al. 2023

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“…[15][16][17] Movie imaging by cine MRI as a means of the functional and dynamic study of the motion of various organs has been used recently. [18][19][20][21] There are, however, no reports of the visual evaluation of the motion of the male pelvic organs by PFMC under normal or post-prostatectomy conditions. Moreover, the mechanism of urinary incontinence after RP has not yet been clarified.…”

Section: Discussionmentioning

confidence: 99%

“…Pelvic cine MRI examination has already been established as a method of imaging‐based evaluation for pelvic organ prolapse or stress urinary incontinence in women 15–17 . Movie imaging by cine MRI as a means of the functional and dynamic study of the motion of various organs has been used recently 18–21 . There are, however, no reports of the visual evaluation of the motion of the male pelvic organs by PFMC under normal or post‐prostatectomy conditions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of levator ani muscle contraction on post‐prostatectomy urinary incontinence using cine MRI

Kumagai¹,

Muraki²,

Yoshimura

2021

Neurourology and Urodynamics

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Post-prostatectomy urinary incontinence (PPI) is the greatest concern for urologists after radical prostatectomy (RP). It is thought that PPI is composed of multiple factors including static and dynamic components. The purpose of this study is to show visually levator ani muscle (LAM) contraction during pelvic floor muscle contraction and to evaluate the dynamic differences in its contraction between men with and without PPI.Methods: This study was a case-control study of the urinary continent or incontinent men. It investigated whether LAM contraction was involved in urinary leakage based on examination of LAM contraction by cine magnetic resonance imaging. Results: The LAM contracted from the coccyx to the pubis in the same manner before and after surgery. The degree of contraction of the LAM in postprostatectomy groups was smaller than that in the healthy adult group. The contraction distances of each part of the pelvic floor were decreased by 50%-70% in the incontinence group compared to those in the continence group. The bladder neck moved 2.5-fold further in the continence group and the direction of movement was more vertical than in the incontinence group. Urethral compression was attenuated by about 40% in the incontinence group compared to that in the continence group.Conclusions: RP can cause damage to the LAM. LAM contraction is reduced after RP compared with that in healthy adult men. In men with PPI, the reduced muscle contraction might not compress the urethra sufficiently when abdominal pressure is raised. Pelvic floor muscle training might provide a meaningful method for the recovery of LAM contraction in patients with PPI.

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“…EP plays essential roles in sperm transportation, menstrual discharge, and embryo implantation, which favor pregnancy and the early development of embryos. It has been reported that any change in the velocity and direction of EP compared to its typical characteristics may lead to infertility or pregnancy failure (Kuijsters et al, 2017;Soares et al, 2019). Various diagnostic technologies, such as intrauterine pressure measurement (IUPs), magnetic resonance imaging (MRI), and transvaginal ultrasonography (TVUS), have been introduced to investigate the EP.…”

Section: Introductionmentioning

confidence: 99%

Automated measurement of endometrial peristalsis in cine transvaginal ultrasound images

Wang

Wei

et al. 2022

Front. Physiol.

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Objectives: Endometrial peristalsis (EP) in non-pregnant uterine can be assessed by visual assessment of transvaginal ultrasound (TVUS). However, visual assessment is subjective, and the outcome depends on the sonographers and video analysts. This study aimed to create a newly developed automatic analysis algorithm for measuring the EP compared to visual assessment.Methods: A retrospective analysis was performed using the datasets from in vitro fertilization and embryo transfer (IVF-ET), who underwent the evaluation of EP by TVUS within 5 days prior to transplantation. 158 cine TVUS images were used to develop the automated analysis algorithm, and 37 cine TVUS images were evaluated by both visual and automated analysis algorithms. The algorithm was developed by applying the optical flow technology and enabled objective analysis of the number, direction, and intensity of EP.Results: The number of peristaltic waves counted by visual assessment was 4.2 ± 2.3 (mean ± standard deviation) and 4.1 ± 2.1 for doctors one and two, respectively. The number of waves counted with the algorithm was 3.6 ± 2.1 at first evaluation and 3.7 ± 2.0 at repeated evaluation. A significant difference was found between the algorithm count and visual assessment (p = 0.001, 0.002, 0.003, 0.008). The ICC values for algorithm versus manuals ranged from 0.84 to 0.96 and 0.87 to 0.96. The numbers of the cervix-to-fundus (CF), fundus-to-cervix (FC), and both cervix-to-fundal and fundus-to-cervix (CF + FC) directions of EP counted by the algorithm were 50, 52, and 32, respectively. The numbers counted by visual assessment were 43, 45, and 46, respectively. The number of EP was the same in 87% of the two algorithm counts. The number was lower between the algorithm and visual analysis (79% with complete agreement). The EP intensity assessed by the algorithm was 2.6 ± 1.1, and the peristalsis velocity was 0.147 (0.07) mm/s.Conclusion: The fully automated analysis algorithm can be used to quantify uterine peristalsis comparable to visual assessment.

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The role of cine MR imaging in the assessment of uterine function

Cited by 10 publications

References 48 publications

Modulating Morphological and Redox/Glycative Alterations in the PCOS Uterus: Effects of Carnitines in PCOS Mice

Modulating Morphological and Redox/Glycative Alterations in the PCOS Uterus: Effects of Carnitines in PCOS Mice

Evaluation of the effect of levator ani muscle contraction on post‐prostatectomy urinary incontinence using cine MRI

Automated measurement of endometrial peristalsis in cine transvaginal ultrasound images

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