The role of circular RNA in Diabetic Nephropathy

Tu, Chao; Wang, Liangzhi; Wei, Lan; Jiang, Zhuyan

doi:10.7150/ijms.71648

Cited by 16 publications

(10 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although previous studies on diabetic nephropathy had the limitation of being restricted to animal experiments, the findings suggest that the circRNA_0001946–miR671-5p–CDR1 axis is a potential therapeutic target for diabetic nephropathy. Findings on other circRNA–miRNA axes such as circRNA_15698–miR-185 also suggested that miRNA regulation may trigger diabetic nephropathy or be involved in the progression of diabetic nephropathy [ 31 , 32 , 33 ]. On the other hand, Hsa_circ_0054633 were also shown to be useful as diagnostic markers of pre-diabetes and type 2 diabetes mellitus [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

circRNAs May Be Involved in Dysfunction of Neutrophils of Type 2 Diabetic Mice through Regulation of Specific miRNAs

et al. 2022

View full text Add to dashboard Cite

Diabetes is known to delay wound healing, and this delay is attributed to prolonged inflammation. We found that microRNAs (miRNAs) might be involved in the dysfunction of diabetic-derived neutrophils, and dynamics of neutrophil and chronic inflammation might be initiated by miRNA-regulated genes. Moreover, studies of miRNA function in nephropathy have suggested that circular RNAs (circRNAs), which function as sponges of miRNA to regulate their expression, are potential biomarkers and new therapeutic targets for the diagnosis of diabetic nephropathy. Accordingly, to investigate the molecular mechanism of the regulation of inflammation in diabetic-derived neutrophils, we identified circRNAs in diabetic-derived neutrophils obtained from BKS.Cg-Dock7m +/+ Leprdb/J (Leprdb/db and Leprdb/+) mice using microarrays. Neutrophils from pooled bone marrow of three diabetic and three non-diabetic mice were isolated and total RNA was extracted. Microarray analysis was performed using the Arraystar Mouse Circular RNA Array. The results showed that three circRNAs were significantly increased and six circRNAs were significantly decreased in diabetic-derived neutrophils compared with non-diabetic-derived neutrophils. The expressions of some circRNAs in diabetic-derived neutrophils were more than double those in non-diabetic-derived neutrophils. The circRNAs contain binding sites of miRNAs, which were differentially expressed in diabetic-derived neutrophils. Our results suggest that circRNAs may be involved in the regulation of inflammation in diabetic-derived neutrophils.

show abstract

Section: Discussionmentioning

confidence: 99%

circRNAs May Be Involved in Dysfunction of Neutrophils of Type 2 Diabetic Mice through Regulation of Specific miRNAs

et al. 2022

View full text Add to dashboard Cite

show abstract

“…These biomolecules—transported by macrovesicles, exosomes, and transmembrane proteins—are involved in the regulation of different pathways promoting fibrosis and inflammation especially in the heart and the kidney [ 12 , 20 , 24 ]. As the lack of influence of glomerular filtration on their urinary levels unlike serum creatinine [ 49 ], miRNAs can be used as innovative biomarker for DN even at the preclinical stage [ 25 , 27 , 28 ].…”

Section: Evidence On the Role Of Mirnas -21 -126 -216 And -377 In Dn ...mentioning

confidence: 99%

“…Besides classical markers (e.g., urinary cystatin C) [ 10 , 19 , 20 , 21 ], novel promising options are emerging in this research area [ 14 , 20 , 22 ]. In this framework, a pathogenic role for microRNAs (miRNAs) as biomolecules regulating up to 30% of the protein-coding genes in the human genome has been also proposed [ 23 , 24 , 25 , 26 ]. To date, miRNAs represent the most attractive candidates as potential diagnostic, prognostic, and therapeutic DN tool [ 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Pediatric Diabetic Nephropathy: Novel Insights from microRNAs

Lanzaro

Barlabà

Nigris

et al. 2023

JCM

View full text Add to dashboard Cite

Diabetic nephropathy (DN) represents the most common microvascular complication in patients with diabetes. This progressive kidney disease has been recognized as the major cause of end-stage renal disease with higher morbidity and mortality. However, its tangled pathophysiology is still not fully known. Due to the serious health burden of DN, novel potential biomarkers have been proposed to improve early identification of the disease. In this complex landscape, several lines of evidence supported a critical role of microRNAs (miRNAs) in regulating posttranscriptional levels of protein-coding genes involved in DN pathophysiology. Indeed, intriguing data showed that deregulation of certain miRNAs (e.g., miRNAs 21, -25, -92, -210, -126, -216, and -377) were pathogenically linked to the onset and the progression of DN, suggesting not only a role as early biomarkers but also as potential therapeutic targets. To date, these regulatory biomolecules represent the most promising diagnostic and therapeutic options for DN in adult patients, while similar pediatric evidence is still limited. More, findings from these elegant studies, although promising, need to be deeper investigated in larger validation studies. In an attempt to provide a comprehensive pediatric overview in the field, we aimed to summarize the most recent evidence on the emerging role of miRNAs in pediatric DN pathophysiology.

show abstract

“…Thus, a better understanding of the complex cellular and molecular events could help us to improve antifibrotic therapies for renal fibrosis. Accumulating evidence has implicated circRNAs in the pathogenesis of renal fibrosis [ 77 , 78 ]. For instance, circ_0000064 is upregulated in mesangial cells from high glucose (HG)-induced renal fibrosis and in kidneys from patients with diabetic nephropathy.…”

Section: Introductionmentioning

confidence: 99%

CircRNAs: versatile players and new targets in organ fibrosis

et al. 2023

View full text Add to dashboard Cite

Organ fibrosis can occur in virtually all major organs with relentlessly progressive and irreversible progress, ultimately resulting in organ dysfunction and potentially death. Unfortunately, current clinical treatments cannot halt or reverse the progression of fibrosis to end-stage organ failure, and thus, advanced antifibrotic therapeutics are urgently needed. In recent years, a growing body of research has revealed that circular RNAs (circRNAs) play pivotal roles in the development and progression of organ fibrosis through highly diverse mechanisms of action. Thus, manipulating circRNAs has emerged as a promising strategy to mitigate fibrosis across different organ types. In this review, we systemically summarize the current state of knowledge about circRNA biological properties and the regulatory mechanisms of circRNAs. A comprehensive overview of major fibrotic signaling pathways and representative circRNAs that are known to modulate fibrotic signals are outlined. Then, we focus on the research progress of the versatile functional roles and underlying molecular mechanisms of circRNAs in various fibrotic diseases in different organs, including the heart, liver, lung, kidney and skin. Finally, we offer a glimpse into the prospects of circRNA-based interference and therapy, as well as their utilization as biomarkers in the diagnosis and prognosis of fibrotic diseases.

show abstract

The role of circular RNA in Diabetic Nephropathy

Cited by 16 publications

References 47 publications

circRNAs May Be Involved in Dysfunction of Neutrophils of Type 2 Diabetic Mice through Regulation of Specific miRNAs

circRNAs May Be Involved in Dysfunction of Neutrophils of Type 2 Diabetic Mice through Regulation of Specific miRNAs

Pediatric Diabetic Nephropathy: Novel Insights from microRNAs

CircRNAs: versatile players and new targets in organ fibrosis

Contact Info

Product

Resources

About