The role of circulating antibody in the control of metastases

Failure to detect circulating IgG or IgM antibodies to basal cell carcinoma by immunofluorescence

“…The discovery of circulating anti-tumour anti bodies in malignant melanoma and their apparent association with the absence of metastatic spread (2) has led to the suggestion that serum antibodies might be involved in the control of metastasis (3). A search for similar antitumour antibodies in pa tients with basal cell carcinoma therefore appeared to be justified.…”