The Role of Cleaning Products in Epidemic Allergic Contact Dermatitis to Methylchloroisothiazolinone/Methylisothiazolinone

Marrero-Alemán, Gabriel; Santana, Pedro Saavedra; Liuti, Federica; Hernández, Noelia; López‐Jiménez, E.C.; Borrego, Leopoldo

doi:10.1097/der.0000000000000352

Cited by 18 publications

(13 citation statements)

References 10 publications

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“…Finally, our population of MI‐sensitive patients was comparable to those in other documented series of cases of MI contact dermatitis, with patients being predominantly female and the hands and faces being most frequently involved . As previously reported, two thirds of the products implicated were cosmetics, followed by household products. Our series also confirmed the high share (11%) of water‐based paints as a cause of the condition, together with the involvement of cosmetic and household products containing MI in cases of domestic MI dermatitis .…”

Section: Discussionsupporting

confidence: 81%

Methylisothiazolinone allergic contact dermatitis: Assessment of relapses in 139 patients after avoidance advice

et al. 2019

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Background Methylisothiazolinone (MI) is a preservative that is responsible for an epidemic of allergic contact dermatitis (ACD). Few studies have been published on the prognosis of patients with MI‐induced ACD. Objectives To evaluate relapses of MI‐induced ACD and difficulties in avoiding MI in patients who had received avoidance advice. Methods A retrospective study of patients with MI‐induced ACD diagnosed in two specialized dermato‐allergology units between 2010 and 2015 was performed. The median follow‐up was 3 years. Results Relapses were observed in 64% of 139 included patients, and were severe in 18%. Rinse‐off cosmetics were responsible for the largest proportion of relapses (27%). The median time to relapse was 5 months. Sixty‐nine per cent of relapses were on the hands, and 29% were on the face. Risk factors for relapsing were hand eczema and a personal history of atopy. The main difficulties encountered in the avoidance strategy were hidden sources of MI, the lack of labelling on industrial products, the complexity of cosmetic labelling, and remembering the name of the allergen. Conclusion MI‐induced ACD has a poor prognosis. Its high rate of relapse is mainly attributable to the difficulties of avoidance. Management needs to be improved. Specialized follow‐up in the year following diagnosis is essential to educate patients.

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Section: Discussionsupporting

confidence: 81%

Methylisothiazolinone allergic contact dermatitis: Assessment of relapses in 139 patients after avoidance advice

et al. 2019

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“…15 A few years later, the EU member states committed to following the above-mentioned opinion. 3,16 As the Thai FDA usually takes a few years to adopt EU regulations, total prohibition of the use of MI in Thailand has not yet been imposed. It seems reasonable to assume that the incidence of MCI/MI or MI contact allergy would vary according to the different consumer exposure levels and the regulations in force in different regions.…”

Section: Discussionmentioning

confidence: 99%

Methylchloroisothiazolinone and/or methylisothiazolinone in cosmetic products—A market survey

et al. 2018

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Background: There was a global epidemic of methylchloroisothiazolinone (MCI) and/or methylisothiazolinone (MI) contact allergy from 2009 to 2015. In response, the Thai Ministry of Public Health regulated the use of MCI/MI in cosmetics.Objective: To survey the presence of MCI/MI and MI alone, as labelled on cosmetics sold on the Thai market, before and after the ministerial directive. Methods:The presence of MCI and/or MI in leave-on and rinse-off cosmetics sold on the market, based on the labelling of ingredients in 3445 products, was analysed.Results: Before the implementation date, most leave-on products contained MCI/MI. After the regulations came into force, the only leave-on cosmetic subcategories that complied with the law were facial skin-care, sunscreen and make-up products. MCI/MI and MI alone were found on the labels of both leave-on and rinse-off products, the presence of each varying between product subcategories.Conclusions: Despite the ministerial regulations restricting their use, MCI and/or MI are still found in cosmetics sold on the Thai market. Dermatologists should be aware of this situation, and counsel patients to avoid products containing MCI and/or MI. K E Y W O R D S cosmetics, ingredient labelling, isothiazolinones, methylchloroisothiazolinone, methylisothiazolinone, skin-care products Leave-on Facial skin care 717 (35.5) 623 (36.2) 94 (31.8) Body skin care 478 (23.7) 408 (23.7) 70 (23.6) Make-up 292 (14.5) 247 (14.3) 45 (15.2) Sun care 245 (12.1) 212 (12.3) 33 (11.2) Hair care 168 (8.3)

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“…The same study also identified a significant shift of currently clinically relevant products, that is, those products which elicited ACD leading to consultation for patch testing, from leave-on cosmetics to rinse-off cosmetics and household products. The latter product category has led to a significant increase in occupational ACD in cleaners [100]. In Australia, the use of MI in leave-on products was banned in October 2017, while 100 ppm was maintained as the concentration limit for rinse-off cosmetics.…”

Section: Preservativesmentioning

confidence: 99%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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The Role of Cleaning Products in Epidemic Allergic Contact Dermatitis to Methylchloroisothiazolinone/Methylisothiazolinone

Cited by 18 publications

References 10 publications

Methylisothiazolinone allergic contact dermatitis: Assessment of relapses in 139 patients after avoidance advice

Methylisothiazolinone allergic contact dermatitis: Assessment of relapses in 139 patients after avoidance advice

Methylchloroisothiazolinone and/or methylisothiazolinone in cosmetic products—A market survey

Contact Allergy—Emerging Allergens and Public Health Impact

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