The Role of Colchicine in Coronary Artery Disease

Butt, Asra; Cave, Brandon; Maturana, Miguel; Towers, William F.; Khouzam, Rami N.

doi:10.1016/j.cpcardiol.2020.100690

Cited by 5 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Colchicine is an ancient and inexpensive oral drug with extensive anti-in ammatory properties 22 , which has been mainly used for the treatment of gout and familial Mediterranean fever in the past. In recent years, studies have shown that colchicine has many effects on the treatment of coronary heart disease 23,24 . Speci c manifestations were as follows:…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of colchicine in patients with acute coronary syndrome: A meta-analysis of randomized control trials

Yan,

Wu,

et al. 2022

Preprint

View full text Add to dashboard Cite

Colchicine has an obvious anti-inflammatory effect. The occurrence of acute coronary syndrome (ACS) is accompanied by a series of inflammatory reactions. We aimed to evaluate the efficacy and safety of colchicine in patients with ACS. Randomized controlled studies (RCTS) about the effects of colchicine on the treatment of patients with ACS were identified by searching databases including PubMed, EMBASE, Web of Science, and Cochrane Library. A meta-analysis was performed using RevMan5.3 statistical software. Eight RCTs with 6730 patients were included in the meta-analysis, involving 3362 patients in the colchicine group and 3368 patients in the control group. Compared with the control group, the major adverse cardiovascular events (MACE) [OR 0.69, 95% confidence interval (CI) 0.57–0.83], recurrence of ACS (OR 0.71, 95% CI 0.56-0.91), revascularization (OR 0.45, 95% CI 0.29-0.70), and stroke (OR 0.36, 95% CI 0.17-0.75) were reduced in the colchicine group, but there were no significant differences in cardiac death, all-cause mortality, or gastrointestinal symptoms. In conclusion, Colchicine can be used as a new effective and safe medicine for the treatment of ACS, which can effectively reduce the occurrence of MACE, cardiovascular and cerebrovascular ischemic events, and revascularization without increasing the adverse reactions. The results is expected to be further verified by increasing the clinical sample size in the future.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of colchicine in patients with acute coronary syndrome: A meta-analysis of randomized control trials

Yan,

Wu,

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…All rabbits were examined by MRI, F‐FDG PET/CT, optical correlation tomography (OCT) and histological assessment. The results showed that colchicine may have the effect of stabilizing atherosclerotic plaque by reducing inflammation and plaque load without changing macrophage infiltration and plaque type 39 …”

Section: Research Progress Of Colchicine In the Treatment Of Atherosclerosismentioning

confidence: 98%

Anti‐inflammatory mechanisms and research progress of colchicine in atherosclerotic therapy

Zhang

et al. 2021

J Cellular Molecular Medi

View full text Add to dashboard Cite

Inflammatory responses play a vital role in the onset and development of atherosclerosis, and throughout the entire process of the chronic disease. The inflammatory responses in atherosclerosis are mainly mediated by the NLRP3 inflammasome and its downstream inflammatory factors. As a powerful anti‐inflammatory medicine, colchicine has a history of more than 200 years in clinical application and is the first‐choice treatment for immune diseases such as gout and familial Mediterranean fever. In atherosclerosis, colchicine can inhibit the assembly and activation of NLRP3 inflammasome via various mechanisms to effectively reduce the expression of inflammatory factors, thereby reducing the inflammation. Recent clinical trials show that a low dose of colchicine (0.5 mg per day) has a certain protective effect in stable angina patients or those with acute myocardial infarction after PCI. This article summarizes and discusses the mechanisms of colchicine in the treatment of atherosclerosis and the latest research progress.

show abstract

“…Colchicine-A rat model of atrial fibrillation revealed the action of colchicine on renin inhibition, indicating its potential use in CHD treatment (Yue et al, 2019). It has also been shown to inhibit the NLRP3 inflammasome pathway, decrease thromboxane A2, leukotriene B4, and cyclo-oxygenase 2 levels, and increase prostaglandin E2 production (Butt et al, 2021). Colchicine is a potent antagonist of the RAS and has the potential to become a new standard therapy for the prevention of CHD (Yong et al, 2022).…”

Section: Pharmacological Agentsmentioning

confidence: 99%

Role of the renin–angiotensin system in the pathophysiology of coronary heart disease and heart failure: Diagnostic biomarkers and therapy with drugs and natural products

et al. 2023

View full text Add to dashboard Cite

The renin–angiotensin system (RAS) plays a pivotal role in blood pressure regulation. In some cases, this steering mechanism is affected by various deleterious factors (mainly via the overactivation of the RAS) causing cardiovascular damage, including coronary heart disease (CHD) that can ultimately lead to chronic heart failure (CHF). This not only causes cardiovascular disability and absenteeism from work but also imposes significant healthcare costs globally. The incidence of cardiovascular diseases has escalated exponentially over the years with the major outcome in the form of CHD, stroke, and CHF. The involvement of the RAS in various diseases has been extensively researched with significant limelight on CHD. The RAS may trigger a cascade of events that lead to atherosclerotic mayhem, which causes CHD and related aggravation by damaging the endothelial lining of blood vessels via various inflammatory and oxidative stress pathways. Although there are various diagnostic tests and treatments available in the market, there is a constant need for the development of procedures and therapeutic strategies that increase patient compliance and reduce the associated side effects. This review highlights the advances in the diagnostic and treatment domains for CHD, which would help in subjugating the side effects caused by conventional therapy.

show abstract

The Role of Colchicine in Coronary Artery Disease

Cited by 5 publications

References 46 publications

Efficacy and safety of colchicine in patients with acute coronary syndrome: A meta-analysis of randomized control trials

Efficacy and safety of colchicine in patients with acute coronary syndrome: A meta-analysis of randomized control trials

Anti‐inflammatory mechanisms and research progress of colchicine in atherosclerotic therapy

Role of the renin–angiotensin system in the pathophysiology of coronary heart disease and heart failure: Diagnostic biomarkers and therapy with drugs and natural products

Contact Info

Product

Resources

About