The role of color doppler in assisted reproduction: A narrative review

Sharma, Nidhi; Saravanan, Mahalakshmi; Saravanan, Lakshmanan; Narayanan, Sindujhaa

doi:10.18502/ijrm.v17i10.5484

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…Additionally, VEGF is one of the most relevant angiogenic factors studied to date in orchestrating folliculogenesis ( 22 ). Elevated VEGF levels in FF have been observed in both natural and IVF cycles, and it has been established that mature follicles originate from highly vascularized follicles ( 23 , 24 ). Moreover, in hormone-stimulated IVF cycles involving patients with normal ovarian response, a positive correlation was found between VEGF levels in FF and the extent of peri-follicular vascularity on the day of follicle aspiration ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of potential angiogenic biomarkers in human follicular fluid for predicting oocyte maturity

Chen,

Wu,

Lin

et al. 2023

Front. Endocrinol.

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BackgroundAngiogenesis in folliculogenesis contributes to oocyte developmental competence in natural and in vitro fertilization (IVF) cycles. Therefore, the identification of key angiogenic factors in follicular fluid (FF) during folliculogenesis is clinically significant and important for in vitro fertilization. This study aims to identify the key angiogenic factors in FF for predicting oocyte maturity during in vitro fertilization.Materials and methodsForty participants who received ovarian stimulation using a GnRH antagonist protocol in their first in vitro fertilization treatment were recruited. From each patient, two follicular samples (one preovulatory follicle, > 18 mm; one mid-antral follicle, < 14 mm) were collected without flushing during oocyte retrieval. In total, 80 FF samples were collected from 40 patients. The expression profiles of angiogenesis-related proteins in FF were analyzed via Luminex high-performance assays. Recorded patient data included antral follicle count, anti-müllerian hormone, age, and BMI. Serum samples were collected on menstrual cycle day 2, the trigger day, and the day of oocyte retrieval. Hormone concentrations including day 2 FSH/LH/E2/P4, trigger day E2/LH/P4, and retrieval day E2/LH/P4 were measured by chemiluminescence assay.ResultsTen angiogenic factors were highly expressed in FF: eotaxin, Gro-α, IL-8, IP-10, MCP-1, MIG, PAI-1 (Serpin), VEGF-A, CXCL-6, and HGF. The concentrations of eotaxin, IL-8, MCP1, PAI-1, and VEGF-A were significantly higher in preovulatory follicles than those in mid-antral follicles, while the Gro-α and CXCL-6 expressional levels were lower in preovulatory than in mid-antral follicles (p < 0.05). Logistic regression and receiver operating characteristic (ROC) analysis revealed that VEGF-A, eotaxin, and CXCL-6 were the three strongest predictors of oocyte maturity. The combination of VEGF-A and CXCL-6 predicted oocyte maturity with a higher sensitivity (91.7%) and specificity (72.7%) than other combinations.ConclusionOur findings suggest that VEGF-A, eotaxin, and CXCL-6 concentrations in FF strongly correlate with oocyte maturity from the mid-antral to preovulatory stage. The combination of VEGF-A and CXCL-6 exhibits a relatively good prediction rate of oocyte maturity during in vitro fertilization.

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Section: Discussionmentioning

confidence: 99%

Identification of potential angiogenic biomarkers in human follicular fluid for predicting oocyte maturity

Chen,

Wu,

Lin

et al. 2023

Front. Endocrinol.

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“…Vascularity in the follicular rim first becomes visible or detectable when the follicle reaches 10 mm in diameter [ 19 ]. A mature follicle is approximately 16–18 mm in diameter, anechoic internally, and very thin-walled [ 20 ].…”

Section: Ovarian Blood Flowmentioning

confidence: 99%

“…Studies assessing the blood flow in the spiral arteries showed similar patterns of blood flow in the uterine arteries during the menstrual cycle. The RI of spiral arteries remains high in the follicular phase and decreases rapidly to a level of 0.48 3 days before ovulation [ 19 ]. On 3D Doppler, the VI, FI, and VFI increase from the midfollicular phase, peaking 3 days before ovulation, and then decrease, reaching a nadir 5 days post-ovulation, before gradually increasing again during the mid-luteal phase [ 60 ].…”

Section: Endometrial Blood Flowmentioning

confidence: 99%

Doppler ultrasound investigation of female infertility

2023

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This study reviewed recent advances in the use of Doppler ultrasonography for the management and prediction of female infertility outcomes of assisted reproductive technology (ART). Color or power Doppler and three-dimensional power Doppler ultrasound can be used to measure vessels near the ovaries, uterus, and endometrium to assess blood flow. Increased blood flow and reduced resistance to the ovaries, uterus, and endometrium are associated with improved pregnancy outcomes, and their measurement has been suggested as a key factor in ART procedural outcomes.Perifollicular vascularity indices can help predict oocyte quality and maturity. Likewise, endometrial and uterine vascularity could be associated with endometrial receptivity and may assist with embryo transfer timing and pregnancy outcome predictions. With the advancement of Doppler ultrasound technology, this highly potent examination will be used more widely in routine clinical settings for the treatment of female infertility.

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“…In order to assess ovarian blood flow before to in vitro embryo development, color Doppler ultrasonography was initially used in humanassisted reproduction in the 1990s [67][68][69][70]. According to more recent studies using the pulsatility index, women with unexplained infertility exhibited reduced uterine and ovarian arterial blood perfusion during the luteal phase [71,72].…”

Section: Using Color Doppler To Assess Vascularitymentioning

confidence: 99%

Application of Color Doppler Ultrasound in Egyptian Buffalo Reproduction

Elmetwally

Gohar

Tawfik³

et al. 2023

Egyptian Journal of Veterinary Sciences

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T HE Color Doppler ultrasonography is widely utilized in equines, dairy cattle, and small ruminants as a safe, non-invasive means of monitoring reproductive performance. Non-intrusive color Doppler ultrasonography was utilized to evaluate high-risk pregnancies and the health of the fetus. The alterations that take place in farm animals after giving birth are thought to be crucial in predicting future fertility. B mode ultrasonography has been applied in several studies on postpartum buffaloes. Color Doppler ultrasonography is a non-invasive technique that can be used before, during, and after delivery. Using the uterine and umbilical arteries, it is possible to evaluate the perfusion of the uteroplacental and fetoplacental blood flow in buffaloes. The motion of the transmitter and receiver affects the frequency of an ultrasonic pulse, which is a phenomenon called the Doppler Effect, and was initially described by Christian Doppler. Nowadays, the use of color Doppler ultrasonography has followed the same pattern as that of cows and other animals. Doppler ultrasound application's basis is likened to cows. The blood supply to the uterus is remarkably similar. Recent research have described the features of vaginal blood circulation in buffaloes throughout gestation and the early puerperium in addition to the uterine blood flow. The impact of vaginal blood circulation on buffalo fertility needs to be studied in the future. We highlight the different benefits of non-invasive color Doppler ultrasound applications in the buffalo's reproduction.

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The role of color doppler in assisted reproduction: A narrative review

Cited by 6 publications

References 31 publications

Identification of potential angiogenic biomarkers in human follicular fluid for predicting oocyte maturity

Identification of potential angiogenic biomarkers in human follicular fluid for predicting oocyte maturity

Doppler ultrasound investigation of female infertility

Application of Color Doppler Ultrasound in Egyptian Buffalo Reproduction

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