The Role of Combined Nicotine and Caffeine Administration on the Histological Structure of the Rat Urinary Bladder with a Special Reference to P53

Allehaibi, Alhan I; Abunasef, Siham K.; Zaki, Azza I.

doi:10.4172/2157-7099.1000455

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…Additionally, these results cope with Suzuki et al [33] who observed the occurrence of apoptosis, and oxidative stress in the urothelium of the urinary bladder and attributed the generation of some ROS in the urothelium to the cell proliferation and other intracellular and extracellular mechanisms. Moreover, it agreed with Allehaibi et al [28] who found that injection of nicotine resulted in positive expression of p53 in some cells of lamina propria suggesting that it affects the proliferating epithelium mitogenically rather than cytotoxically as mentioned before by Cohen [34] in human study and Apasov et al [35] in animal study.…”

Section: Figure (5): the Urothelial Cells Of F-air And E-liq Groups (...supporting

confidence: 89%

“…These outcomes supported by Dodmane et al [37], Allehaibi et al [28], Suzuki et al [33], Suzuki et al [38] and Suzuki et al [39] who found hyperplasia of urinary bladder epithelium after oral administration of nicotine which indicate increased number of proliferating cells. Also agreed with Tang et al [2] who found flat and/or papillary urothelial hyperplasia with increased mitotic activity in some E-cig exposed mice.…”

Section: Figure (5): the Urothelial Cells Of F-air And E-liq Groups (...mentioning

confidence: 58%

“…Moreover, it was supported by Allehaibi et al [28] who mentioned that following nicotine treatment, intraepithelial lymphocytes were found in several areas of the urinary bladder, and the condition was diagnosed as a recurrent common reactive inflammatory illness as recorded by Grignon and Sakr [29] and Kagami et al [30]. Besides, Al Dera [31] and Wang et al [32] attributed the rise in TNF-α to the rupture of the cellular basement membrane, which caused a number of inflammatory and immune cells to migrate to the site of the damage and release a variety of cytokines that exacerbated the inflammatory response.…”

Section: Figure (5): the Urothelial Cells Of F-air And E-liq Groups (...mentioning

confidence: 69%

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Comparison between the Effect of Nicotine Smoking in Tobacco and Electronic Cigarettes on Urinary Bladder in Adult Male Albino Rats: Biochemical and Histopathological Study

Abdelwahab

Abdel-Kareem²,

Domouky³

2023

Zagazig University Medical Journal

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Background: Electronic cigarette (E-cig) is a device that instead of burning tobacco leaves evaporates a nicotine solution mixed with liquid tastes. E-cig has been readily available since its introduction in 2004, and its usage has expanded tremendously over the world. This work aimed to compare between the electronic cigarette consumption and tobacco cigarette smoking on urinary bladder, as regard the histopathological effect, oxidative, inflammatory, and apoptotic markers through biochemical and immunohistochemical methods. Forty rats were divided to 4 groups (fresh-air, E-Liquid, E-cigarette, and Tcigarette), after 8 weeks of exposure, rats were weighted and the urinary bladder of all rats were obtained for histological and biochemical analysis.Results: both tobacco and electronic cigarette smoking resulted in a reduction in body weight with increase in urinary bladder weight, an increase in inflammatory marker activity (TNF-α, IL-6, and macrophage inflammatory protein levels), and an oxidant/antioxidant imbalance in rats (increase in ROS level, plus decrease in total antioxidant activity). Furthermore, cigarette smoking caused histological structural injury to the urinary bladder, with overexpression of Ki-67 and poor expression of E-cadherin, all results were more pronounced in tobacco cigarette smoking.Conclusions: According to this study, even if electronic cigarettes have lesser pathological and biochemical effects on the urinary bladder than tobacco cigarettes, they still cause urinary bladder injury, hence it is strongly advised to avoid any devices that contain nicotine.

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Section: Figure (5): the Urothelial Cells Of F-air And E-liq Groups (...supporting

confidence: 89%

Section: Figure (5): the Urothelial Cells Of F-air And E-liq Groups (...mentioning

confidence: 58%

Section: Figure (5): the Urothelial Cells Of F-air And E-liq Groups (...mentioning

confidence: 69%

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Comparison between the Effect of Nicotine Smoking in Tobacco and Electronic Cigarettes on Urinary Bladder in Adult Male Albino Rats: Biochemical and Histopathological Study

Abdelwahab

Abdel-Kareem²,

Domouky³

2023

Zagazig University Medical Journal

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“…By Frossard JL [7], the author discusses by giving a case report the question whether every pancreatic mass, which in 15% of the cases has another diagnosis than adenocarcinoma, should be diagnosed by a fine needle aspiration.…”

Section: In the Research Article Spermatocyte Spreading During Meiotimentioning

confidence: 99%

Opinion on Important Findings for the Diagnosis and Therapy in Clinical Medicine

Werner¹

2017

J Cytol Histol

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The Role of Combined Nicotine and Caffeine Administration on the Histological Structure of the Rat Urinary Bladder with a Special Reference to P53

Cited by 2 publications

References 22 publications

Comparison between the Effect of Nicotine Smoking in Tobacco and Electronic Cigarettes on Urinary Bladder in Adult Male Albino Rats: Biochemical and Histopathological Study

Comparison between the Effect of Nicotine Smoking in Tobacco and Electronic Cigarettes on Urinary Bladder in Adult Male Albino Rats: Biochemical and Histopathological Study

Opinion on Important Findings for the Diagnosis and Therapy in Clinical Medicine

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