The role of complement factor C3 in lipid metabolism

Barbu, Andreea; Hamad, Osama A.; Lind, Lars; Ekdahl, Kristina Nilsson; Nilsson, Bo

doi:10.1016/j.molimm.2015.02.027

Cited by 99 publications

(75 citation statements)

References 86 publications

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“…62 Apoptotic cells shed membrane-bound complement regulators such as MCP/CD46 and CD59, 71 while the presence of circulating complement regulators, for example, CFH, prevents the reaction from escalating and affecting nearby cells. 61 Additional nonimmunological physiological roles for complement activity include neuronal synapse remodeling, 72,73 lipid metabolism, 74 and bone remodeling. 75 …”

Section: Pathogenesis Of Geographic Atrophymentioning

confidence: 99%

The Pathophysiology of Geographic Atrophy Secondary to Age-Related Macular Degeneration and the Complement Pathway as a Therapeutic Target

Boyer

Schmidt‐Erfurth

Campagne³

et al. 2017

Retina

197

159

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Section: Pathogenesis Of Geographic Atrophymentioning

confidence: 99%

The Pathophysiology of Geographic Atrophy Secondary to Age-Related Macular Degeneration and the Complement Pathway as a Therapeutic Target

Boyer

Schmidt‐Erfurth

Campagne³

et al. 2017

Retina

197

159

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show abstract

“…The mRNA expression of CfB, C3, and adipsin in our study reflects observations made in vivo in other studies. In addition, in agreement with literature (Wlazlo et al, 2014;Barbu et al, 2015;Vlaicu et al, 2016;van Greevenbroek et al, 2012;Moreno-Navarrete et al, 2010) and our ms data, CfB expression was increased when co-cultures of adipocytes and macrophages were stimulated with LPS for 18 h compared to non-stimulated co-cultures ( Figure 3B). In contrast, C3…”

Section: Identification Of Novel Proteins Involved In Inflamed Adipossupporting

confidence: 92%

Novel targets for the development of drugs for Type 2 Diabetes Mellitus

Sotiriou¹

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“…On the other hand C3 and its cleavage product C3a desArg are now recognized to have important roles in lipid storage and metabolism. C3a desArg, like insulin, stimulates FFA and glucose uptake in adipocytes, and it is generated in proportion to the total amount of C3 33 . Very recently the anaphylatoxins C3a and C5a have been shown to have insulin-like properties as well 20 .…”

Section: Discussionmentioning

confidence: 99%

Complement factors C4 and C3 are down regulated in response to short term overfeeding in healthy young men

Foghmar

Brøns

Pilely

et al. 2017

Sci Rep

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Insulin resistance is associated with high circulating level of complement factor C3. Animal studies suggest that improper complement activation mediates high-fat-diet-induced insulin resistance. Individuals born with low birth weight (LBW) are at increased risk of developing insulin resistance. We hypothesized that high-fat overfeeding (HFO) increase circulating C3 and induce complement activation in a birth weight differential manner. Twenty LBW and 26 normal birth weight (NBW) young men were studied using a randomised crossover design. Insulin resistance was measured after a control-diet and after 5-days HFO by a hyperinsulinemic-euglycemic-clamp. Circulating C4, C3, ficolins, mannose-binding-lectin, complement activation products C3bc, terminal complement complex (TCC) and complement activation capacity were determined using turbidimetry and ELISA. HFO induced peripheral insulin resistance in LBW individuals only, while both groups had the same degree of hepatic insulin resistance after HFO. Viewing all individuals circulating levels of C4, C3, C3bc, TCC and complement activation capacity decreased paradoxically along the development of insulin resistance after HFO (P = 0.0015, P < 0.0001, P = 0.01, P < 0.0001, P = 0.0002, P < 0.0001, P = 0.0006). Birth weight did not influence these results. This might reflect a hitherto unrecognized down-regulatory mechanism of the complement system. More human studies are needed to understand the underlying physiology and the potential consequences of these findings.

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The role of complement factor C3 in lipid metabolism

Cited by 99 publications

References 86 publications

The Pathophysiology of Geographic Atrophy Secondary to Age-Related Macular Degeneration and the Complement Pathway as a Therapeutic Target

The Pathophysiology of Geographic Atrophy Secondary to Age-Related Macular Degeneration and the Complement Pathway as a Therapeutic Target

Novel targets for the development of drugs for Type 2 Diabetes Mellitus

Complement factors C4 and C3 are down regulated in response to short term overfeeding in healthy young men

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