The role of computed tomography for node staging in gastric cancer: A center's retrospective analysis

Sousa, Marta; Magalhães, Helena; Araújo, Rosa; Pires, A.; Brito, Daniel; Machado, Manuela; Sousa, Olga; Santos, Lúcio Lara

doi:10.1093/annonc/mdx261.096

Cited by 2 publications

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“…The sensitivity for CT scan in diagnosing malignant lymph node disease is variable [10], and in our clinical practice experience it can be even lower than published in the literature (35% vs 60% -90%) [11]. Still today, a global consensus on malignant lymph node disease diagnostic criteria is not available [10], so we believe that a better understanding of the role of the different imaging modalities is necessary for better patient selection.…”

Section: Discussionmentioning

confidence: 88%

Perioperative Treatment in Gastric Cancer—Developments in Patient Selection

Machado¹,

Magalhães²,

Fontes‐Sousa³

2018

JCT

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Gastric cancer (GC) is a major public health issue. It is considered the 5 th most common cancer diagnosed worldwide and it is one of the main causes of malignant disease-associated morbidity and mortality. The cornerstone of curative treatment is still surgery, and since the rate of relapse is high, a multidisciplinary approach is warranted in most developed countries. And while there have been recent developments in the perioperative scenario namely the FLOT regimen, little has advanced considering patient selection. We have reviewed the major trials in this setting and provide some insights from recently reported microsatellite instability (MSI) in a subgroup analysis in the MAGIC trial patients that seem to suggest an opportunity to patient selection. Furthermore, GC subtyping may prove helpful selecting candidates to immunotherapy or even multimodal therapy in the future. As the paradigm is moving towards a precision oncology model, GC patient selection remains one the biggest challenges in oncology but seems closer to clinical practice reality as new developments are being reported.

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Section: Discussionmentioning

confidence: 88%

Perioperative Treatment in Gastric Cancer—Developments in Patient Selection

Machado¹,

Magalhães²,

Fontes‐Sousa³

2018

JCT

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“…To evaluate and stage the possible extension of the disease preoperatively, computerized tomography (CT) has demonstrated a sensitivity and specificity greater than 80% when staging the tumor using the Tumor, Nodules, and Metastasis (TNM) classification. 8,9 Gastric adenocarcinoma is a pathology with a high tendency for lymph node metastasis, and therefore, accurate preoperative assessment of this is considered one of the highly predictive factors for determining survival rates following surgical resection. 10,11 The use of tomographic imaging techniques has allowed improvement of preoperative staging of gastric adenocarcinoma in recent years.…”

Section: Introductionmentioning

confidence: 99%

Survival and adequate preoperative staging in patients undergoing gastric cancer surgery at a Peruvian Police Hospital

Panduro-Correa

Cubas

Herrera-Matta

et al. 2020

Journal of Surgical Oncology

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IntroductionGastric cancer is the fifth most common malignant neoplasm and the third leading cause of cancer‐related death worldwide. In Peru, its incidence is 15.8 per 100,000 population, and it is associated with high mortality rates, especially in areas with low socioeconomic status. The aim of this study was to compare preoperative, postoperative, and anatomopathological staging results and their relation to disease recurrence and survival.MethodsWe conducted a retrospective cohort study of patients undergoing surgery for gastric cancer with a definitive postoperative anatomopathological diagnosis from 2005 to 2014 at the Hospital Nacional Luis N. Sáenz. Statistical analyses included descriptive and correlation statistics using the κ index, determination of associations between preoperative and postoperative staging and surgical reintervention and recurrence using the χ2 test, as well as Kaplan Meier survival analysis.ResultsThere was little correlation between preoperative staging and final anatomopathological diagnosis, while there was a good correlation with postoperative staging. A significant association was found between preoperative staging and cancer recurrence. In the survival analysis, survival was lower among patients with underestimated staging.ConclusionsThe survival of patients with gastric cancer can be affected by an overestimation of preoperative staging, therefore improvements in preoperative staging could lengthen the survival of patients undergoing gastric cancer surgery.

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The role of computed tomography for node staging in gastric cancer: A center's retrospective analysis

Cited by 2 publications

References 0 publications

Perioperative Treatment in Gastric Cancer—Developments in Patient Selection

Perioperative Treatment in Gastric Cancer—Developments in Patient Selection

Survival and adequate preoperative staging in patients undergoing gastric cancer surgery at a Peruvian Police Hospital

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