The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes

Antypa, Niki; Drago, Antonio; Serretti, Alessandro

doi:10.1016/j.neubiorev.2013.06.006

Cited by 95 publications

(60 citation statements)

References 134 publications

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“…As predicted, the link between the two variables was significant only in the average to above-average range of emotional distress. This result is in line with previous literature in that COMT Val 158 Met influences on the brain and underlying cognitive responses can be modulated by stress and mood (Antypa, Drago, & Serretti, 2013;Buckert et al, 2012). More specifically, its phenotypic expression becomes visible especially under stress or emotional manifestations of stress.…”

Section: A-priori Moderation Resultssupporting

confidence: 92%

Genetic Correlates of Maladaptive Beliefs: COMT VAL158MET and Irrational Cognitions Linked Depending on Distress

et al. 2015

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Section: A-priori Moderation Resultssupporting

confidence: 92%

Genetic Correlates of Maladaptive Beliefs: COMT VAL158MET and Irrational Cognitions Linked Depending on Distress

et al. 2015

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“…Previous studies have identified associations between mutations and polymorphisms within the Comt gene and cognition impairment, working memory, depression, and early life experiences, thereby demonstrating its direct functional role in the response to stress (Antypa et al, 2013;Baumann et al, 2013;Colzato et al, 2013;Hernaus et al, 2013;Opmeer et al, 2013;Sheikh et al, 2013). Furthermore, it has been shown that SNPs can influence the epigenetic regulation of this gene.…”

Section: Discussionmentioning

confidence: 98%

Effects of environmental noise exposure on DNA methylation in the brain and metabolic health

Guo

et al. 2017

Environmental Research

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Environmental noise exposure is associated with adverse effects on human health including hearing loss, heart disease, and changes in stress-related hormone levels. Alteration in DNA methylation in response to environmental exposures is a well-known phenomenon and it is implicated in many human diseases. Understanding how environmental noise exposures affect DNA methylation patterns may help to elucidate the link between noise and adverse effects on health. In this pilot study we examined the effects of environmental noise exposure on DNA methylation of genes related to brain function and investigated whether these changes are related with metabolic health. We exposed four groups of male Wistar rats to moderate intensity noise (70-75dB with 20-4000Hz) at night for three days as short-term exposure, and for three weeks as long-term exposure. Noise exposure was limited to 45dB during the daytime. Control groups were exposed to only 45dB, day and night. We measured DNA methylation in the Bdnf, Comt, Crhr1, Mc2r, and Snca genes in tissue from four brain regions of the rats (hippocampus, frontal lobe, medulla oblongata, and inferior colliculus). Further, we measured blood pressure and body weight after long-term noise exposure. We found that environmental noise exposure is associated with gene-specific DNA methylation changes in specific regions of the brain. Changes in DNA methylation are significantly associated with changes in body weight (between Bdnf DNA methylation and Δ body weight: r=0.59, p=0.018; and between LINE-1 ORF DNA methylation and Δ body weight: =-0.80, p=0.0004). We also observed that noise exposure decreased blood pressure (p=0.038 for SBP, p=0.017 for DBP and p 0. 017 for MAP) and decreased body weight (β=-26g, p=0.008). In conclusion, environmental noise exposures can induce changes in DNA methylation in the brain, which may be associated with adverse effects upon metabolic health through modulation of response to stress-related hormones.

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“…The link between the levels of dopamine (low or high) and positive emotionality is contradictory, but it has become clear that dopamine plays an essential role in this correlation [44][45][46][47]. This relationship may underlie associations between COMT p.Val158Met and symptoms in several psychopathologic conditions, including schizophrenia, bipolar disorder and depression [15,48,49].…”

Section: Discussionmentioning

confidence: 99%

Association of p.Val158Met COMT polymorphism with paranoid ideation in drug addicts

Ribeiro¹,

Curto²,

Areias³

et al. 2017

IJCNMH

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Introduction: Drug addiction is one of the most devastating brain disorders, involving the impairment of brain reward pathway. The enzyme catechol-O-methyltransferase (COMT) metabolizes dopamine and influences the reward pathway functioning. COMT activity is influenced by genetic variations, particularly the p.Val158Met (rs4680); the Met/ Met genotype has been associated with a 40% reduction in enzyme activity. The aim of this study was to determine p.Val158Met COMT polymorphism in a Portuguese population of drugs addicts seeking treatment and its association with paranoid ideation.

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The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes

Cited by 95 publications

References 134 publications

Genetic Correlates of Maladaptive Beliefs: COMT VAL158MET and Irrational Cognitions Linked Depending on Distress

Genetic Correlates of Maladaptive Beliefs: COMT VAL158MET and Irrational Cognitions Linked Depending on Distress

Effects of environmental noise exposure on DNA methylation in the brain and metabolic health

Association of p.Val158Met COMT polymorphism with paranoid ideation in drug addicts

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