The role of concurrent determinations of pleural fluid and tissue carcinoembryonic antigen in the distinction of malignant mesothelioma from metastatic pleural malignancies

Faravelli, B; Nosenzo, Marco; Razzetti, Alfredo; Barone, Daniela; D'Amore, Eugenio; Bandelloni, Roberto; Gambini, Claudio; Pg, Betta; Donna, A

doi:10.1016/0277-5379(85)90295-0

Cited by 19 publications

(12 citation statements)

References 7 publications

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“…The current study demonstrated very low values of CEA in pleural effusions due to malignant mesothelioma. This finding is in agreement with previous studies [14,15]. However, as shown here, CEA values in a number of malignant pleural effusions due to lung adenocarcinoma do not exceed the cut-off value.…”

Section: Discussionsupporting

confidence: 94%

“…The CEA assay system in this study showed a relatively low cut-off value (2.5 ng·ml -1 ) in plasma for cancers [15]. The cut-off value (100 ng·ml -1 ) of SP-A assay in pleural effusions corresponds to the prior cut-off value (500 ng·ml -1 ) when using human SP-A purified full-term amniotic effusions as standards [6].…”

Section: Discrimination Between Lung Adenocarcinoma and Mesotheliomamentioning

confidence: 63%

“…Several studies [14,15,17,18] have also demonstrated that measurements of CEA are of diagnostic value in malignant pleural effusions. By contrast, reactivity against CEA is negative or only weakly positive in mesothelioma [11-13, 19, 20].…”

Section: Discussionmentioning

confidence: 99%

“…Plasma levels of CEA are increased in patients with various cancers, and CEA has been expressed in cancer tissues. By contrast, CEA has not been found immunohistochemically in mesothelioma [11][12][13], and CEA levels are not increased in malignant effusions due to malignant mesothelioma [14,15].…”

Section: Patientsmentioning

confidence: 99%

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Lung surfactant protein-A and carcinoembryonic antigen in pleural effusions due to lung adenocarcinoma and malignant mesothelioma

Shijubo¹,

Honda²,

Fujishima³

et al. 1995

Eur Respir J

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Lung surfactant protein-A (SP-A) is a major phospholipid-associated glycoprotein in surfactant, and is a useful immunohistochemical marker for lung adenocarcinoma. Carcinoembryonic antigen (CEA) has not been immunohistochemically detected in mesothelioma. In pleural effusions due to malignant mesothelioma, very low concentrations of SP-A and CEA can be expected. We studied the value of combined determinations of CEA and SP-A in pleural fluid to distinguish between lung adenocarcinoma and mesothelioma. SP-A and CEA concentrations were measured in pleural effusions from 78 patients with lung adenocarcinoma and 10 with malignant mesothelioma. SP-A concentrations in pleural effusions due to lung adenocarcinoma and mesothelioma were 516 +/- 140 and 16.9 +/- 3.6 ng.ml-1 (mean +/- SEM), respectively. CEA concentrations in pleural effusions due to lung adenocarcinoma and mesothelioma were 239 +/- 92.4 and 1.7 +/- 0.3 ng.ml-1, respectively. SP-A values did not exceed 100 ng.ml-1 in any of 10 mesotheliomas, whilst in 37 of 78 lung adenocarcinomas they did. CEA values did not exceed 10 ng.ml-1 in any of 10 mesotheliomas, whilst in 53 of 78 lung adenocarcinomas they did. Increased values of SP-A and/or CEA were found in pleural effusions from 67 of 78 lung adenocarcinomas. It is concluded that a combination of CEA and SP-A assays in pleural effusions will be helpful for discriminating lung adenocarcinoma from mesothelioma.

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Section: Discussionsupporting

confidence: 94%

Section: Discrimination Between Lung Adenocarcinoma and Mesotheliomamentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Lung surfactant protein-A and carcinoembryonic antigen in pleural effusions due to lung adenocarcinoma and malignant mesothelioma

Shijubo¹,

Honda²,

Fujishima³

et al. 1995

Eur Respir J

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show abstract

“…Several investigators highlighted that determination of tumor marker levels might be useful in distinguishing the type of cancer. Wagner et Faravelli, found CA 15-3 level to be higher in patients with metastatic cancer compared to that of mesothelioma cases (17,18). While Porcel et al, found CEA level showing an increase of 59% in lung cancer and 71% in gastrointestinal cancer cases, they determined CA-125 level in patients with ovarium cancer as 67%.…”

Section: Discussionmentioning

confidence: 96%

Diagnostic Value Of CEA, CA-19-9, CA 125 And CA 15-3 Levels In Malignant Pleural Fluids

et al. 2007

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Diagnostic value of CA 72-4, carcinoembryonic antigen, CA 15-3, and CA 19-9 assay in pleural fluid: A study of 207 patients

Villena

López-Encuentra

Echave-Sustaeta

et al. 1996

Cancer

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The role of concurrent determinations of pleural fluid and tissue carcinoembryonic antigen in the distinction of malignant mesothelioma from metastatic pleural malignancies

Cited by 19 publications

References 7 publications

Lung surfactant protein-A and carcinoembryonic antigen in pleural effusions due to lung adenocarcinoma and malignant mesothelioma

Lung surfactant protein-A and carcinoembryonic antigen in pleural effusions due to lung adenocarcinoma and malignant mesothelioma

Diagnostic Value Of CEA, CA-19-9, CA 125 And CA 15-3 Levels In Malignant Pleural Fluids

Diagnostic value of CA 72-4, carcinoembryonic antigen, CA 15-3, and CA 19-9 assay in pleural fluid: A study of 207 patients

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