The role of cone-beam breast-CT for breast cancer detection relative to breast density

Wienbeck, Susanne; Uhlig, Johannes; Luftner-Nagel, Susanne; Zapf, Antonia; Surov, Alexey; Fintel, Eva von; Stahnke, Vera; Lotz, Joachim; Fischer, Uwe

doi:10.1007/s00330-017-4911-z

Cited by 43 publications

(49 citation statements)

References 28 publications

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“…Breast computed tomography is a cross-sectional imaging technique with a proven higher diagnostic accuracy compared with mammography regarding breast lesions. [11][12][13] The higher accuracy results from the largely resolved overlapping of the breast tissue and the possibility to analyze imaging findings in multiple anatomical planes from a single scan. Up to now, resolution of B-CT did not reach high enough resolution to visualize microcalcifications, which the new dedicated B-CT can provide.…”

Section: Discussionmentioning

confidence: 99%

“…Breast computed tomography has the potential to further improve breast lesion detection and characterization compared with mammography and tomosynthesis. [11][12][13] Previous studies investigating the use of cone beam B-CT in comparison to mammography reported higher radiation doses for B-CT, especially when referring to a screening setting. 13,14 More recently, new strategies have strongly increased the dose efficiency due to the use of novel photon-counting detector technology, resulting in dose levels for B-CT comparable to those of screening mammography or lower.…”

mentioning

confidence: 99%

“…[11][12][13] Previous studies investigating the use of cone beam B-CT in comparison to mammography reported higher radiation doses for B-CT, especially when referring to a screening setting. 13,14 More recently, new strategies have strongly increased the dose efficiency due to the use of novel photon-counting detector technology, resulting in dose levels for B-CT comparable to those of screening mammography or lower. 15,16 In conventional energy-integrating detectors (EIDs), the electrical signal is generated by a photodiode, which detects the visible light produced by the interaction of the x-ray photons with a scintillator material.…”

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confidence: 99%

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Dedicated Breast Computed Tomography With a Photon-Counting Detector

et al. 2019

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OBJECTIVES: The purpose of this work is to present the data obtained from the first clinical in vivo application of a new dedicated spiral breast computed tomography (B-CT) equipped with a photon-counting detector. MATERIALS AND METHODS: The institutional review board approved this retrospective study. Twelve women referred for breast cancer screening were included and underwent bilateral spiral B-CT acquired in prone position. Additional sonography was performed in case of dense breast tissue or any B-CT findings. In 3 women, previous mammography was available for comparison. Soft tissue (ST) and high-resolution (HR) images were reconstructed. Two independent radiologists performed separately the readout for subjective image quality and for imaging findings detection. Objective image quality evaluation was performed in consensus and included spatial resolution, contrast resolution, signal-to-noise ratio (SNR), and contrast-to-noise ratio. All women were asked to report about positioning comfort and overall comfort during data acquisition. RESULTS: The major pectoral muscle was included in 15 breast CT scans (62.5%); glandular component was partially missing in 2 (8.3%) of the 24 scanned breasts. A thin "ring artifact" was present in all scans but had no influence on image interpretations; no other artifacts were present. Subjective image quality assessment showed excellent agreement between the 2 readers (= 1). Three masses were depicted in B-CT and were confirmed as simple cysts in sonography. Additional 5 simple cysts and 2 solid benign lesions were identified only in sonography. A total of 12 calcifications were depicted with a median size of 1.1 mm (interquartile range, 0.7-1.7 mm) on HR and 1.4 mm (interquartile range, 1.1-1.8 mm) on ST images. Median SNRgl, SNRfat, and contrast-to-noise ratio were significantly higher in ST than in HR reconstructions (each, P < 0.001). A mild discomfort due to positioning of the rib cage on the table was reported by 2 women (16.7%); otherwise, no discomfort was reported. CONCLUSIONS: The new dedicated B-CT equipped with a photon-counting detector provides high-quality images with potential for screening of breast cancer along with minor patient discomfort.

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Section: Discussionmentioning

confidence: 99%

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Dedicated Breast Computed Tomography With a Photon-Counting Detector

et al. 2019

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“…CTDIw = 8 mGy ± 20% with one 360°scan at 49 kVp, 100 mA, and 8 ms pulse duration) [9]. Reports indicate that in BCT exams the MGD can be comparable to that of diagnostic mammography [9,10,55], and several times larger than that used in two-view screening mammography [28,56]. Sechopoulos et al [28] calculated the pDgN CT coefficients for the Koning Corp. scanner located at the Emory University (whose scans are adopted in this work, with beam quality 49 kVp and HVL = 1.39 mm Al).…”

Section: Discussionmentioning

confidence: 99%

Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast: Homogeneous and heterogeneous breast models

et al. 2018

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“…Dedicated Breast Computed Tomography (DBCT) uses a cone-beam system to perform a true tomographic scan capable of achieving near isotropic resolution in any plane with less noise than DBT and without breast compression [89], and has been demonstrated to be 21.5% more sensitive than mammography in detecting breast lesions [125]. Still in the innovation stages, current prototypes position the patient prone over a breast aperture enabling exclusion of the thorax and body from radiation exposure.…”

Section: Approaches Which Employ Ionising Radiationmentioning

confidence: 99%

Looking beyond the mammogram to assess mammographic density: A narrative review

Hugo

Tourell

O’Gorman

et al. 2018

BSI

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MD-the white areas on a mammogram (also known as breast density), has long been recognised as an indicator of breast cancer (BC) risk and mammographic masking. Recent legislation in 32 American states has mandated the inclusion of mammography density information in reports for women in the higher two MD quartiles, and it is a growing consideration worldwide. While the mammogram is currently the only means of estimating MD, it suffers from a number of limitations. These are related to the accumulation of low dose ionising radiation used in mammography that limits its repeated use, particularly in young women, women with previous radiation exposure, those having undergone prior surgery, or those with radio-sensitising gene mutations. This review compares and contrasts the variety of emerging technologies that can provide a quantitative and true volumetric analysis of breast density, without the use of ionising radiation.

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The role of cone-beam breast-CT for breast cancer detection relative to breast density

Cited by 43 publications

References 28 publications

Dedicated Breast Computed Tomography With a Photon-Counting Detector

Dedicated Breast Computed Tomography With a Photon-Counting Detector

Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast: Homogeneous and heterogeneous breast models

Looking beyond the mammogram to assess mammographic density: A narrative review

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