The Role of Cone-Beam CT in Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis

Pung, Leland; Ahmad, Moiz; Mueller, Kerstin; Rosenberg, Jarrett; Stave, Christopher D; Hwang, Gloria L.; Shah, Rajesh P.; Kothary, Nishita

doi:10.1016/j.jvir.2016.11.037

Cited by 80 publications

(56 citation statements)

References 38 publications

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“…Similar results about the detection of small focal lesions less than 1 cm were reported in the meta-analysis done by Pung et al [22] who reported that tumors more than 30 mm were easier to be detected by cone beam CT; however, the advantage of the high-contrast, three-dimensional images remained for tumors less than 10 mm and the tumors that could not be detected by angiography (Fig. 5).…”

Section: Discussionsupporting

confidence: 85%

Comparison between C-arm cone beam computed tomography and interventional angiography in transarterial chemoembolization of hepatocellular carcinoma

Diab

Hassanein

Mohamed

2019

Egypt J Radiol Nucl Med

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Background: Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy of adults. One of the established treatment procedures performed worldwide for HCC is transcatheter arterial chemoembolization (TACE). By using conventional angiography in TACE, we can detect and identify the vascular anatomy of the liver through obtaining 2D images. Recently C-arm cone beam computed tomography (CBCT) is introduced for obtaining cross-sectional and three-dimensional (3D) images for better visualization of small tumors and their feeding arteries. Results: The number of detected focal lesions by angiography was 51 compared to 87 focal lesion detected by CBCT; of those, 45 and 77 were active lesions by both procedures respectively. For lesions, less than 1 cm CBCT detected 23 lesions while angiography detected only one lesion. Angiography detected 87 feeding arterial branch while cone beam CT-HA detected 130 branches to the same number of target lesion. Feeder tractability and confidence were better by CBCT. Conclusion: CBCT is superior to angiography in tumor detectability, detection of lesions less than 1 cm, feeder detection, and feeder traction; however, conventional angiography and DSA are irreplaceable. Thus, combination of CBCT with angiography during TACE produces better results and less complication.

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Section: Discussionsupporting

confidence: 85%

Comparison between C-arm cone beam computed tomography and interventional angiography in transarterial chemoembolization of hepatocellular carcinoma

Diab

Hassanein

Mohamed

2019

Egypt J Radiol Nucl Med

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“…Cone beam CT can enable direct monitoring, and can supply additional information from DSA imaging; this could impact decision making during chemoembolization through the improved detection of tumors (19 …”

Section: Discussionmentioning

confidence: 99%

Detection of Recurrent/Residual Hepatocellular Carcinoma: Single-Center Retrospective Comparative Study Between Parenchymal Blood Volume Mapping Using Cone Beam CT and Multiphase Dynamic CT

Kim

Kim²,

Han

et al. 2018

J Korean Soc Radiol

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Purpose:To evaluate the usefulness of cone beam computed tomography (CT)-based parenchymal blood volume (PBV) mapping for the detection of marginal recurrence or residual hepatocellular carcinoma, after transcatheter arterial chemoembolization (TACE), and to compare it with multiphase dynamic CT (MDCT). Materials and Methods: From March 2015 to October 2016, 26 patients with 49 iodized nodules who underwent TACE and a pre-interventional MDCT scan were enrolled in our study. We evaluated the diagnostic efficacies of PBV mapping using cone beam CT and MDCT in the detection of marginal recurrences or viable tumors. Results: The sensitivity, specificity, positive predictive value, and negative predictive value (NPV) of PBV mapping and MDCT were 100%, 96.7%, 94.7%, and 100%, and 77.9%, 93.5%, 87.5%, and 87.8%, respectively. The overall sensitivity for identifying local marginal recurrence was higher for PBV mapping than for MDCT (p < 0.005). The performances of PBV mapping and MDCT in the diagnosis of local marginal recurrence were significantly different (p = 0.037, McNemar test). Conclusion: Compared with MDCT, PBV mapping can significantly increase the detection of marginal recurrence or residual tumor after TACE because it is free of beam-hardening artifact. PBV mapping should be considered as a feasible modalityrelated tool for patients who have undergone chemoembolization. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Index terms

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“…Development of the hybrid CT/angiography system and C-arm cone-beam CT technology provides crosssectional imaging as an adjunct to catheter angiography with or without intra-arterial contrast. This can be used with image fusion or co-registration with catheter angiogram to help localize and perform selective TACE [36][37][38] .…”

Section: On-table Ctmentioning

confidence: 99%

Technical update on transcatheter arterial chemoembolization

Puppala¹

2019

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Transcatheter arterial chemoembolization has become an established drug delivery system for palliative or bridging treatment of hepatocellular carcinoma. Over the last two decades, various research and developments have taken place to improve the transcatheter arterial chemoembolization procedure from both a clinical and a technical perspective. This review article aims to provide an update on the technical developments over the last decade.

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The Role of Cone-Beam CT in Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis

Cited by 80 publications

References 38 publications

Comparison between C-arm cone beam computed tomography and interventional angiography in transarterial chemoembolization of hepatocellular carcinoma

Comparison between C-arm cone beam computed tomography and interventional angiography in transarterial chemoembolization of hepatocellular carcinoma

Detection of Recurrent/Residual Hepatocellular Carcinoma: Single-Center Retrospective Comparative Study Between Parenchymal Blood Volume Mapping Using Cone Beam CT and Multiphase Dynamic CT

Technical update on transcatheter arterial chemoembolization

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