The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation

Hou, Ping; Liu, Guiying; Zhao, Yingjun; Shi, Zhun; Zheng, Qiuyang; Bu, Guojun; Xu, Huaxi; Zhang, Yunwu

doi:10.1016/j.neurobiolaging.2014.12.005

Cited by 28 publications

(21 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Copper plays a major role in the processing of beta-amyloid, a molecule central to the neurodegeneration seen in Alzheimer’s disease [25, 26]. Also, the protection of neurons from toxic effects of amyloid involves astrocytic mitochondria, and could be compromised if astrocytic mitochondria are damaged [27].…”

Section: Discussionmentioning

confidence: 99%

Copper accumulation in rodent brain astrocytes: A species difference

Sullivan

Robison

Pushkar

et al. 2017

Journal of Trace Elements in Medicine and Biology

View full text Add to dashboard Cite

Changes in Cu homeostasis have been implicated in multiple neurodegenerative diseases. Factors controlling and regulating the distribution of Cu in the brain remain largely unknown. We have previously reported that a sub-set of astrocytes in the subventricular zone (SVZ) contain Cu-rich aggregates. Here we expand previous studies with detailed X-ray fluorescent imaging (XRF) analysis of the additional brain areas of hippocampus (HP) and rostral migratory stream (RMS). We also use conventional DAB (3,3’-diaminobenzidine) staining which accesses both peroxidase and pseudo-peroxidase activities. Both the HP and RMS support neurogenesis while the latter also serves as a migratory pathway for neuronal precursors. Some variations in neurogenic activities have been noticed between species (such as mice and rats). We report here that in rats, the HP, rostral migratory stream (RMS) and third ventricle contain glia which stain positively for DAB and contain copper-rich aggregates as measured by XRF. In contrast, mice hippocampi and RMS display neither DAB+ aggregates nor Cu-rich accumulations via XRF. DAB+ aggregates were not induced in the HP of mice transgenic for human amyloid precursor protein (APP) and presenilin, suggesting that accumulations positively stained for DAB are not directly caused by APP. These observed critical differences suggest different properties of the astrocytes in two species. Results suggest that the rat model may have important advantages over the mouse model for the study of hippocampal aging and neurodegeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Copper accumulation in rodent brain astrocytes: A species difference

Sullivan

Robison

Pushkar

et al. 2017

Journal of Trace Elements in Medicine and Biology

View full text Add to dashboard Cite

show abstract

“…For instance, increased levels of copper and altered copper homeostasis contribute to AD by promoting beta-amyloid secretions. 24,25 Dysregulation of neuronal zinc homeostasis also plays a key role in AD (Ref. 26) by inducing parenchymal and cerebrovascular amyloids in transgenic mice.…”

Section: Introductionmentioning

confidence: 99%

Texture analyses of quantitative susceptibility maps to differentiate Alzheimer's disease from cognitive normal and mild cognitive impairment

Hwang

Kim

et al. 2016

Med. Phys.

View full text Add to dashboard Cite

show abstract

“…This class of enzymes is modulated by physiological metals (Hou et al, 2015;Gerber et al, 2017). However, as previously seen, the 100 µmol L The results presented herein suggest that INHHQ and HPCIH possess intracellular activity; however, the potential interaction of the compounds with secretases still needs further investigations.…”

Section: Sw App Hek 293supporting

confidence: 48%

Activity Evaluation and Toxicological Profile of New Potential Metal Protein Attenuating Compounds in Biological Models of Alzheimer S Disease

Falco¹

View full text Add to dashboard Cite

The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation

Cited by 28 publications

References 28 publications

Copper accumulation in rodent brain astrocytes: A species difference

Copper accumulation in rodent brain astrocytes: A species difference

Texture analyses of quantitative susceptibility maps to differentiate Alzheimer's disease from cognitive normal and mild cognitive impairment

Activity Evaluation and Toxicological Profile of New Potential Metal Protein Attenuating Compounds in Biological Models of Alzheimer S Disease

Contact Info

Product

Resources

About