The Role of Copper as a Modifier of Lipid Metabolism

Burkhead, Jason L.; Lutsenko, Svetlana

doi:10.5772/51819

Cited by 16 publications

(7 citation statements)

References 100 publications

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“…This is another proof that the deficit of Cu in the rat diet may negatively affect the body by weakening the antioxidant defence. Also, low level of Cu in the diet may adversely affect lipid metabolism and lead to an increase in the TG, TC or LDL levels in serum (Kaya et al, 2006;Burkhead and Lutsenko, 2013;Megahed et al, 2014). However, the results of our research do not confirm these reports.…”

Section: Discussioncontrasting

confidence: 91%

The effect of copper level in the diet on the distribution, and biological and immunological responses in a rat model

Cholewińska¹,

Fotschki²,

Juśkiewicz³

et al. 2018

J. Anim. Feed Sci.

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Section: Discussioncontrasting

confidence: 91%

The effect of copper level in the diet on the distribution, and biological and immunological responses in a rat model

Cholewińska¹,

Fotschki²,

Juśkiewicz³

et al. 2018

J. Anim. Feed Sci.

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“…16,17 On the other hand, misregulation of copper is also implicated in human genetic disorders like Menkes 18–20 and Wilson’s 21–23 diseases; neurodegenerative diseases 24 such as Alzheimer’s, 25–28 Parkinson’s, 29 prion, 30,31 and Huntington’s 32 diseases and familial amyotrophic lateral sclerosis; 33 and metabolic disorders such as obesity and diabetes. 34–38 More recently, copper has also been found to regulate cancers that operate through widely observed oncogenic BRAF mutations 6,39,40 and influence tumour growth. In addition to the canonical, tightly bound pool of copper, the observation of a reversibly and relatively loosely bound (“labile”) pool of copper in cells, 41–44 likely buffered by low molecular weight ligands like glutathione (GSH), is particularly intriguing, presaging that copper and related transition metals in these more bioavailable forms can also participate in dynamic cell signalling pathways.…”

Section: Introductionmentioning

confidence: 99%

Synthetic fluorescent probes for studying copper in biological systems

et al. 2015

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The potent redox activity of copper is required for sustaining life. Mismanagement of its cellular pools, however, can result in oxidative stress and damage connected to aging, neurodegenerative diseases, and metabolic disorders. Therefore, copper homeostasis is tightly regulated by cells and tissues. Whereas copper and other transition metal ions are commonly thought of as static cofactors buried within protein active sites, emerging data points to the presence of additional loosely bound, labile pools that can participate in dynamic signalling pathways. Against this backdrop, we review advances in sensing labile copper pools and understanding their functions using synthetic fluorescent indicators. Following brief introductions to cellular copper homeostasis and considerations in sensor design, we survey available fluorescent copper probes and evaluate their properties in the context of their utility as effective biological screening tools. We emphasize the need for combined chemical and biological evaluation of these reagents, as well as the value of complementing probe data with other techniques for characterizing the different pools of metal ions in biological systems. This holistic approach will maximize the exciting opportunities for these and related chemical technologies in the study and discovery of novel biology of metals.

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“…Both hepatic iron excess, as seen in the P3 specimens, and depletion, as detected in the P4 rats, can cause mitochondrial dysfunction and impair the glico-lipidic control [ 57 , 58 ]. Glico-lipidic imbalance can also occur in the case of copper depletion, as observed in the P4 rats, finally leading to non-alcoholic fatty liver disease [ 59 , 60 ]. Moreover, manganese accumulation not only causes liver dysfunction, but the excess not excreted into the bile is transported to the central nervous system, causing neurotoxicity [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Trace Metal Accumulation in Rats Exposed to Mine Waters: A Case Study, Bor Area (Serbia)

Caraba,

Hutanu

et al. 2023

Toxics

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Zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), cadmium (Cd), and lead (Pb) levels were measured in the Bor City water supply system (control) and two watercourses exposed to mining wastewaters, i.e., the Lutarica River (one site) and the Kriveljska River (two sites). The same parameters were determined in the brain, heart, lungs, stomach, liver, spleen, kidneys, and testes of male Wistar rats given water from these sources for 2 months. Water Cu, Fe, Cd, and Pb were outside the safe range, excepting the reference site. Significant impacts on intra-organ metal homeostasis were detected, especially in the brain, stomach, kidneys, and testes. The dynamics and magnitude of these changes (versus controls) depended on the target organ, analyzed metal, and water origin. The greatest number of significant intra-organ associations between essential and non-essential metals were found for Cd-Zn, Cd-Cu, and Cd-Mn. A regression analysis suggested the kidneys as the most relevant organ for monitoring water manganese, and the stomach and brain for lead. These results highlight the environmental risks associated with mining wastewaters from the Bor area and could help scientists in mapping the spatial distribution and severity of trace metal contamination in water sources.

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The Role of Copper as a Modifier of Lipid Metabolism

Cited by 16 publications

References 100 publications

The effect of copper level in the diet on the distribution, and biological and immunological responses in a rat model

The effect of copper level in the diet on the distribution, and biological and immunological responses in a rat model

Synthetic fluorescent probes for studying copper in biological systems

Trace Metal Accumulation in Rats Exposed to Mine Waters: A Case Study, Bor Area (Serbia)

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