The Role of Core Needle Biopsy and Its Impact on Surgical Management in Patients with Medullary Thyroid Cancer: Clinical Experience at 3 Medical Institutions

Ha, Eun Joo; Baek, Jung Hwan; Na, D.G.; Kim, J.-h.; Kim, J.K.; Min, Hye Sook; Song, Dong Eun; Lee, K.E.; Shong, Young Kee

doi:10.3174/ajnr.a4317

Cited by 27 publications

(37 citation statements)

References 34 publications

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“…When thyroid lymphoma or anaplastic cancer is suggested, CNB is preferable to FNA in many studies (16404142). A recent study suggested a role for CNB in medullary thyroid carcinoma (43). …”

Section: Indicationsmentioning

confidence: 99%

“…Core needle biopsy has been reported to be useful for the specific diagnosis of some malignant thyroid lesions, especially lymphoma, anaplastic carcinoma, and medullary carcinoma (16264379). Both anaplastic thyroid cancer and thyroid lymphoma can be present as rapidly growing thyroid masses in elderly patients (80).…”

Section: Clinical Outcomesmentioning

confidence: 99%

“…In a large multicenter study of 191 patients with medullary carcinoma, CNB also achieved higher sensitivity and positive predictive values than FNA. Therefore, CNB could be a complementary diagnostic tool to optimize the surgical management of patients with clinically suspected medullary carcinoma (43). …”

Section: Clinical Outcomesmentioning

confidence: 99%

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Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology

Na¹,

et al. 2017

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Core needle biopsy (CNB) has been suggested as a complementary diagnostic method to fine-needle aspiration in patients with thyroid nodules. Many recent CNB studies have suggested a more advanced role for CNB, but there are still no guidelines on its use. Therefore, the Task Force Committee of the Korean Society of Thyroid Radiology has developed the present consensus statement and recommendations for the role of CNB in the diagnosis of thyroid nodules. These recommendations are based on evidence from the current literature and expert consensus.

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“…When thyroid lymphoma or anaplastic cancer is suggested, CNB is preferable to FNA in many studies (16404142). A recent study suggested a role for CNB in medullary thyroid carcinoma (43). …”

Section: Indicationsmentioning

confidence: 99%

Section: Clinical Outcomesmentioning

confidence: 99%

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Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology

Na¹,

et al. 2017

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“…Yoon et al [58] used a new sampling technique [18] in order to validate that CNB is more useful than FNA for diagnosing follicular neoplasms. CNB is reportedly helpful for diagnosing rare thyroid malignancies such as lymphoma and anaplastic and medullary carcinomas [5,17,[59][60][61][62].…”

Section: Subgroup Analysesmentioning

confidence: 99%

The role of core-needle biopsy in the diagnosis of thyroid malignancy in 4580 patients with 4746 thyroid nodules: a systematic review and meta-analysis

et al. 2016

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To evaluate the effectiveness and complications of core-needle biopsy (CNB) compared to fine-needle aspiration (FNA) for diagnosing thyroid malignancy. The Ovid-MEDLINE and EMBASE databases were searched for studies using CNB for diagnosing thyroid malignancy. A meta-analysis was performed to evaluate the diagnostic accuracy, the incidence of non-diagnostic, inconclusive results, and the complications of CNB and FNA. To overcome the heterogeneity, additional analyses based on three, homogeneous inclusion criteria were performed and subgroup analyses were performed. Twenty eligible studies of 4580 patients (4746 nodules) were included. Both CNB and FNA demonstrated a high sensitivity (91 %, 74 %, respectively; p = .053) and specificity (99 %, 100 %, respectively; p = .914). The area under the curve was larger in CNB (0.99) than in FNA (0.94). CNB demonstrated a significantly lower pooled proportion of non-diagnostic (5.5 %; p < .001) and inconclusive results (8.0 %; p < .001) than FNA (22.6 %, 40.2 %, respectively). The complications rate of FNA (0.0 %) was lower than that of CNB (0.01 %), although not significantly (p = .948). This meta-analysis showed variable heterogeneities, i.e., no heterogeneity to considerable heterogeneity. Additional meta-analyses based on three, homogeneous inclusion criteria demonstrated that heterogeneities were reduced, and the results are in agreement with those of all of the included studies. Subgroup analyses have explained the cause of heterogeneity across studies. Both CNB and FNA may be acceptable diagnostic tools for diagnosing thyroid malignancy. CNB may be a complementary diagnostic tool in nodules with initially non-diagnostic and indeterminate results on previous FNA.

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“…This tumor is resistant to external beam radiotherapy and shows poor response to chemotherapy. Hence, surgery is the only strategy for potential treatment [1,4,5]. However, for a successful surgical attempt, one should be familiar with site and extent of disease [6].…”

Section: Introductionmentioning

confidence: 99%

Comparison of 99mTc(V)-DMSA with 99mTc-EDDA/HYNIC-Tyr3-octreotide scintigraphy in the detection of medullary thyroid tumor foci in a patient with elevated level of calcitonin after surgery: a case report

Ullah¹,

Khan²,

Khattak³

et al. 2018

EJMCR

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Background: Technetium-99m pentavalent dimercaptosuccinic acid [ 99m Tc(V)-DMSA] scintigraphy exhibits a crucial role in the preoperative assessment of residual or recurrent medullary thyroid carcinoma (MTC). Case Presentation:99m Tc(V)-DMSA scintigraphy was performed in a patient with histopathologically proven MTC expressing a high level of calcitonin using a locally formulated kit. Marked uptake of the radiotracer was observed by the locally metastatic foci. The same patient was then subjected to somatostatin receptor scintigraphy (Octreoscan) and the results were found comparable. Both the scanning was completed within 24 hours with good quality images. Conclusion:In-house preparation from renal DMSA kit, better resolution, good stability, and easy procedure with minimum cost make

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The Role of Core Needle Biopsy and Its Impact on Surgical Management in Patients with Medullary Thyroid Cancer: Clinical Experience at 3 Medical Institutions

Abstract: BACKGROUND AND PURPOSE:Medullary thyroid carcinoma is an uncommon malignancy that is challenging to diagnose. Our aim was to present our experience using core needle biopsy for the diagnosis of medullary thyroid carcinoma compared with fine-needle aspiration.

Cited by 27 publications

References 34 publications

Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology

Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology

The role of core-needle biopsy in the diagnosis of thyroid malignancy in 4580 patients with 4746 thyroid nodules: a systematic review and meta-analysis

Comparison of 99mTc(V)-DMSA with 99mTc-EDDA/HYNIC-Tyr3-octreotide scintigraphy in the detection of medullary thyroid tumor foci in a patient with elevated level of calcitonin after surgery: a case report

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