The role of coronary CTA and CT‐fractional flow reserve evaluating coronary artery disease in transcatheter aortic valve replacement

Tipograf, Yuliya; McLaren, Thomas A.; Savoie, Brent; Kumar, Anupam; Levack, Melissa M.

doi:10.1111/jocs.16967

Journal of Cardiac Surgery

2022

DOI: 10.1111/jocs.16967

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The role of coronary CTA and CT‐fractional flow reserve evaluating coronary artery disease in transcatheter aortic valve replacement

Yuliya Tipograf

Thomas A. McLaren

Brent Savoie

et al.

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2024

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The impact of transcatheter aortic valve replacement on changes of coronary computed tomography-derived fractional flow reserve

Hu,

Lai,

Fang

et al. 2024

Annals of Medicine

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Background The effect of transcatheter aortic valve replacement (TAVR) on changes of computed tomography-derived fractional flow reserve (CT-FFR) values was controversial. Thus, we aimed to identify the impact of TAVR on changes of CT-FFR values, plaque characteristics, and the associated clinical impact. Methods This single-center observational study included 39 consecutive patients with severe aortic valve disease undergone TAVR between August 2019 and April 2023, whom were performed with preoperative and postoperative coronary CT angiography (CCTA). The computation of CT-FFR and plaque characteristics was performed by an independent central core laboratory. Results Each patient underwent CCTA and CT-FFR assessment without encountering any complications. Notably, both at discharge and six months post-TAVR, there was a significant improvement observed in the New York Heart Association (NYHA) functional classification, left ventricular fractional shortening, and ejection fraction compared to pre-operative levels. The CT-FFR for left anterior descending artery (LAD), left anterior descending artery (LCX), and right coronary artery (RCA) had no obvious change at discharge compared to pre-operation (0.92 ± 0.05 vs. 0.93 ± 0.05, p = 0.109; 0.96 ± 0.03 vs. 0.95 ± 0.03, p = 0.523; 0.97 ± 0.04 vs. 0.97 ± 0.03, p = 0.533; respectively). Furthermore, TAVR did not exert a significant impact on plaque burden during the perioperative period. Conclusions Our report suggested that TAVR did not significantly affect coronary CT-FFR measurements and plaque characteristics in the perioperative period, and furthermore, the patients’ cardiac function showed gradual improvement in the short-term following discharge.

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The impact of transcatheter aortic valve replacement on changes of coronary computed tomography-derived fractional flow reserve

Hu,

Lai,

Fang

et al. 2024

Annals of Medicine

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The role of coronary CTA and CT‐fractional flow reserve evaluating coronary artery disease in transcatheter aortic valve replacement

Cited by 1 publication

References 12 publications

The impact of transcatheter aortic valve replacement on changes of coronary computed tomography-derived fractional flow reserve

The impact of transcatheter aortic valve replacement on changes of coronary computed tomography-derived fractional flow reserve

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