The role of CPEB family proteins in the nervous system function in the norm and pathology

Kozlov, Eugene; Shidlovskii, Yulii V.; Gilmutdinov, Rudolf; Schedl, Paul; Zhukova, Mariya

doi:10.1186/s13578-021-00577-6

Cited by 33 publications

(35 citation statements)

References 89 publications

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“…Cytoplasmic polyadenylation element-binding (CPEB) proteins promote polyadenylationinduced translation in the cytoplasm [345,346], and all CPEB proteins act as shuttling proteins. The blockade of CRM-1-dependent nuclear export causes the nuclear accumulation of CPEB1, CPEB3, and CPEB4 in human cells.…”

Section: Role Of Ctas In Mrna Processingmentioning

confidence: 99%

Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus

Kachaev

Ivashchenko

Kozlov

et al. 2021

Cells

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Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome integrity control and the nuclear stages of gene expression, such as transcription, mRNA processing, and mRNA export. Components of the translation apparatus control intranuclear trafficking; the nuclear import and export of RNA and proteins; and regulate the activity, stability, and functional recruitment of nuclear proteins. The nuclear translocation of these components is often involved in the cell response to stimulation and stress, in addition to playing critical roles in oncogenesis and viral infection. Many components of the translation apparatus are moonlighting proteins, involved in integral cell stress response and coupling of gene expression subprocesses. Thus, this phenomenon represents a significant interest for both basic and applied molecular biology. Here, we provide an overview of the current data regarding the molecular functions of translation factors and ribosomal proteins in the cell nucleus.

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Section: Role Of Ctas In Mrna Processingmentioning

confidence: 99%

Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus

Kachaev

Ivashchenko

Kozlov

et al. 2021

Cells

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“…CPEB3 is expressed in both the brain and heart and is involved in the regulation of synaptic plasticity by down-regulating the expression of several plasticity-related proteins (PRPs), such as N-methyl-D-aspartate receptor (NMDAR) and postsynaptic density protein 95 (PSD95). Down-regulation of CPEB3 expression can affect NMDAR activated CaMKII α, which overcomes the inhibition of synaptic transmission under stress [ 36 , 37 ]. In addition, CPEB3 knockout mice exhibited hippocampus-dependent neurological dysfunction, including acquisition and extinction of long-term spatial memory and short-term fear memory.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of the functions and prognostic values of RNA-binding proteins in neuroblastoma

Yang

Zhou

et al. 2021

PLoS ONE

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Background Neuroblastoma (NB) is the most common solid tumor in children. NB treatment has made significant progress; however, given the high degree of heterogeneity, basic research findings and their clinical application to NB still face challenges. Herein, we identify novel prognostic models for NB. Methods We obtained RNA expression data of NB and normal nervous tissue from TARGET and GTEx databases and determined the differential expression patterns of RNA binding protein (RBP) genes between normal and cancerous tissues. Lasso regression and Cox regression analyses identified the five most important differentially expressed genes and were used to construct a new prognostic model. The function and prognostic value of these RBPs were systematically studied and the predictive accuracy verified in an independent dataset. Results In total, 348 differentially expressed RBPs were identified. Of these, 166 were up-regulated and 182 down-regulated RBPs. Two hubs RBPs (CPEB3 and CTU1) were identified as prognostic-related genes and were chosen to build the prognostic risk score models. Multivariate Cox analysis was performed on genes from univariate Cox regression and Lasso regression analysis using proportional hazards regression model. A five gene prognostic model: Risk score = (-0.60901*expCPEB3)+(0.851637*expCTU1) was built. Based on this model, the overall survival of patients in the high-risk subgroup was lower (P = 2.152e-04). The area under the curve (AUC) of the receiver-operator characteristic curve of the prognostic model was 0.720 in the TARGET cohort. There were significant differences in the survival rate of patients in the high and low-risk subgroups in the validation data set GSE85047 (P = 0.1237e-08), with the AUC 0.730. The risk model was also regarded as an independent predictor of prognosis (HR = 1.535, 95% CI = 1.368–1.722, P = 2.69E-13). Conclusions This study identified a potential risk model for prognosis in NB using Cox regression analysis. RNA binding proteins (CPEB3 and CTU1) can be used as molecular markers of NB.

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“…CPEs are recognized by CPEB (CPE binding) family proteins. Their functions are conserved from invertebrates to vertebrates [40,41]. The translational control mediated by CPEB proteins is required for early development and neuronal synaptic plasticity.…”

Section: Rna-binding Protein-mediated Translation Regulationmentioning

confidence: 99%

Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors

Fukao

Tomohiro

Fujiwara

2021

Cells

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Protein synthesis is tightly regulated at each step of translation. In particular, the formation of the basic cap-binding complex, eukaryotic initiation factor 4F (eIF4F) complex, on the 5′ cap structure of mRNA is positioned as the rate-limiting step, and various cis-elements on mRNA contribute to fine-tune spatiotemporal protein expression. The cis-element on mRNAs is recognized and bound to the trans-acting factors, which enable the regulation of the translation rate or mRNA stability. In this review, we focus on the molecular mechanism of how the assembly of the eIF4F complex is regulated on the cap structure of mRNAs. We also summarize the fine-tuned regulation of translation initiation by various trans-acting factors through cis-elements on mRNAs.

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The role of CPEB family proteins in the nervous system function in the norm and pathology

Cited by 33 publications

References 89 publications

Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus

Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus

Integrated analysis of the functions and prognostic values of RNA-binding proteins in neuroblastoma

Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors

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