Although the contribution of creative industries to world economy has been widely acknowledged in the last few decades, their failure rate is still high and frustrates creative entrepreneurs. However, few empirical studies have been done to explore what causes creative entrepreneurs' intention to quit. This paper, therefore, aims to draw upon the theories of motivation and entrepreneurship to offer a better understanding of entrepreneurs' withdrawal intention. We incorporate the theory of motivation, creativity, and opportunity to realize their inter-play roles in reducing entrepreneurs' intention to quit in creative industry sector. A sample of 272 creative entrepreneurs in Taiwan's creative industries is used to test the framework we propose. Results show that entrepreneurial creativity and opportunity recognition enhance entrepreneurs' motivation by satisfying the need for basic finance, need for work-life equilibrium, need for social reputation, and need for career achievement. Moreover, we found that entrepreneurs' motivation in need for work-life equilibrium and need for career achievement reduces their intention to quit.