The Role of Cryosurgery of the Prostate for Nonsurgical Candidates

Ej, Abel; K, Wong; Sado, Martins; Ge, Leverson; Patel, M. S.; Tm, Downs; Df, Jarrard

doi:10.4293/108680813x13693422518551

Cited by 32 publications

(15 citation statements)

References 31 publications

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“…Minimally invasive procedure has been shown as an effective way for local treatment of malignancy in solid organ such as liver, prostate and kidney [1,3,14,17,20]. Despite surgery for early stage non-small cell lung cancer (NSCLC) and lung metastasectomy has good tumor control rate, many people are inoperable [31].…”

Section: Discussionmentioning

confidence: 99%

Percutaneous cryoablation for inoperable malignant lung tumors: Midterm results

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Percutaneous cryoablation for inoperable malignant lung tumors: Midterm results

et al. 2015

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“…Twenty-eight publications20212223242526272829303132333435363738394041424344454647, which had reported availably single-arm results of CS treatment for clinically localized PCa, were screened. Sixteen23242526293031333436384142454647 of these papers had presented outcomes for primary therapy, eight2022272832354043 for salvage therapy following RT, one44 for salvage therapy following primary CS, and three213739 for both therapies.…”

Section: Resultsmentioning

confidence: 99%

“…Sixteen23242526293031333436384142454647 of these papers had presented outcomes for primary therapy, eight2022272832354043 for salvage therapy following RT, one44 for salvage therapy following primary CS, and three213739 for both therapies. In addition, materials from the Cryo On-Line Data Registry were used in four publications30404546.…”

Section: Resultsmentioning

confidence: 99%

“…Eighteen studies212224252829323435363738404142434647 showed the outcomes of OS, which revealed a pooled OS of 73–100% at all stages of follow-up (95.9% at year 1, 94.3 at year 3, 73–98.9% OS at year 5, 91–92% at year 8 and 87% at year 10). Fifteen publications212224252729343536373841424347 presented results of 79–100% DSS.…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen publications212224252729343536373841424347 presented results of 79–100% DSS. Differences between primary and salvage treatment were not clear.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Cryosurgery would be An Effective Option for Clinically Localized Prostate Cancer: A Meta-analysis and Systematic Review

Gao

Yang

Qian

et al. 2016

Sci Rep

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Cryosurgery (CS) has been used on patients with clinically localized PCa for more than 10 years. However, clinical studies evaluating its effectiveness and safety have reported conflicting results. This systematic assessment was performed to obtain comprehensive evidence regarding the potential benefits and safety of CS compared with those of radiotherapy (RT) and radical prostatectomy (RP), respectively. All controlled trials comparing CS with RT or RP and single-arm studies reporting results of CS therapy were identified through comprehensive searches of PubMed, the Cochrane Library and Embase. Ten publications from seven trials, with totally 1252 patients, were included in the meta-analysis, which revealed no significant differences in comparisons of CS vs RT and CS vs RP for overall survival and disease specific survival. However, a significantly lower disease-free survival could be observed for CS than RP. Moreover, a systematic review of literature focusing on comparative data of databases and materials of single-arm trials revealed satisfactory survival results in both primary and salvage CS. Our results showed that cryosurgery would be a relatively effective method for clinically localized prostate cancer with survival results comparable to radiotherapy and radical prostatectomy. However, the large percentage of complications caused by cryosurgery should be carefully monitored.

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Prolonged operative time predicts postoperative deep venous thrombosis in head and neck cancer patients who undergo free flap reconstruction

Lee,

Waring,

et al. 2023

Laryngoscope Investig Oto

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ObjectiveThis study sought to quantify the deep venous thrombosis (DVT) incidence in head and neck cancer (HNC) patients undergoing free tissue transfer and to identify independent predictors of postoperative DVT.Materials and MethodsThis is a cross‐sectional study of the National Surgical Quality Improvement Program database from 2010 through 2020. The sample included all HNC surgical patients treated with free flap reconstruction. The study outcome was the presence of a DVT requiring treatment within 30 days of surgery. Univariate analyses were performed using chi‐squared and independent t‐tests. A multiple logistic regression model was created using all significant univariate predictors.ResultsA total of 3954 patients were identified, of whom 53 (1.3%) experienced a postoperative DVT. The only medical comorbidity associated with DVT was COPD (RR = 2.7 [1.3, 5.4]; p < .01). Operative time longer than 9 hours (RR = 1.9 [1.0, 3.2]; p = .04) and length of stay longer than 10 days (RR = 1.9 [1.1, 3.2]; p = .02) were associated with greater DVT rates. In the multivariate analysis, only COPD (p < .01) and operative time (p = .02) were independently associated with DVT risk. The presence of a DVT was found to increase the relative risk of readmission (RR = 2.1 [1.2, 3.6]; p < .01) and non‐home disposition (RR = 2.4 [1.7, 3.5]; p < .01).ConclusionsThe incidence of DVT in HNC free flap patients was comparable to what has been reported in the general population of HNC surgery patients. Operative time >9 h and COPD history were independent risk factors for DVT in this subset of patients. Symptomatic DVTs necessitating treatment were accompanied by poorer post‐hospitalization outcomes.Level of EvidenceLevel 3.

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The Role of Cryosurgery of the Prostate for Nonsurgical Candidates

Abstract: This report describes the experience of using cryosurgery as primary total gland therapy, salvage therapy after radiation failure, and for focal ablation for localized prostate cancer.

Cited by 32 publications

References 31 publications

Percutaneous cryoablation for inoperable malignant lung tumors: Midterm results

Percutaneous cryoablation for inoperable malignant lung tumors: Midterm results

Cryosurgery would be An Effective Option for Clinically Localized Prostate Cancer: A Meta-analysis and Systematic Review

Prolonged operative time predicts postoperative deep venous thrombosis in head and neck cancer patients who undergo free flap reconstruction

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